Thermal and microwave synthesized SPIONs: Energy effects on the efficiency of nano drug carriers

Saxena, Namita; Agraval, Hina; Barick, K. C.; Ray, Debes; Aswal, V. K.; Singh, Anupinder; Yadav, Umesh C. S.; Dube, Charu Lata

doi:10.1016/j.msec.2020.110792

Cited by 11 publications

(9 citation statements)

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“…Photothermal therapy [44] Organic small molecules Citrate Anti-platelet therapy [45] Hyperbranched phenylboronic acid Drug delivery system with pH-responsive ability [46] Serine Targeted drug delivery [47] Oleic acid a) Hydrophobic drug delivery [48] Inorganic materials SiO 2 a)…”

Section:  Challenges In the Development Of Fe  O  Nanozyme-based Tumor Catalytic Therapymentioning

confidence: 99%

Nanozyme for tumor therapy: Surface modification matters

et al. 2021

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As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease of production and modification, paving the way for its biomedical applications. Among them, tumor catalytic therapy mediated by the generation of reactive oxygen species (ROS) has made great progress mainly from the peroxidase-like activity of nanozymes. Fe 3 O 4 nanozymes, the earliest type of nanomaterial discovered to possess peroxidase-like activity, has consequently received wide attention for tumor therapy due to its ROS generation ability and tumor cell killing ability. However, inconsistent results of cytotoxicity were observed between different reports, and some even showed the scavenging of ROS in some cases. By collectively studying these inconsistent outcomes, we raise the question whether surface modification of Fe 3 O 4 nanozymes, either through affecting peroxidase activity or by affecting the biodistribution and intracellular fate, play an important role in its therapeutic effects. This review will go over the fundamental catalytic mechanisms of Fe 3 O 4 nanozymes and recent advances in tumor catalytic therapy, and discuss the importance of surface modification. Employing Fe 3 O 4 nanozymes as an example, we hope to provide an outlook on the improvement of nanozyme-based antitumor activity. K E Y WO R D S cytotoxicity, Fe 3 O 4 nanozymes, peroxidase-like activity, surface modification, tumor catalytic therapy This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section:  Challenges In the Development Of Fe  O  Nanozyme-based Tumor Catalytic Therapymentioning

confidence: 99%

Nanozyme for tumor therapy: Surface modification matters

et al. 2021

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“…The in vitro tests supported the applicability of the SPIONs as effective and targetable drug carriers through successful internalizations and subsequent cell apoptosis, despite the lower drug release from the microwave sample. The relevance of energy in regulating the efficiency and functional behavior of SPIONs as a nano-scale drug carrier was, again, established for their efficacy, biocompatibility, and magnetization-based performance for effective and targeted drug delivery option [ 47 ].…”

Section: Dox Delivery: Spions’ Polymeric Monomeric and Miscellaneous ...mentioning

confidence: 99%

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

et al. 2022

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Considerable efforts have been directed towards development of nano-structured carriers to overcome the limitations of anticancer drug, doxorubicin’s, delivery to various cancer sites. The drug’s severe toxicity to cardio and hepatic systems, low therapeutic outcomes, inappropriate dose–demands, metastatic and general resistance, together with non-selectivity of the drug have led to the development of superparamagnetic iron oxide nanoparticles (SPIONs)-based drug delivery modules. Nano-scale polymeric co-encapsulation of the drug, doxorubicin, with SPIONs, the SPIONs surface end-groups’ cappings with small molecular entities, as well as structural modifications of the SPIONs’ surface-located functional end-groups, to attach the doxorubicin, have been achieved through chemical bonding by conjugation and cross-linking of natural and synthetic polymers, attachments of SPIONs made directly to the non-polymeric entities, and attachments made through mediation of molecular-spacer as well as non-spacer mediated attachments of several types of chemical entities, together with the physico-chemical bondings of the moieties, e.g., peptides, proteins, antibodies, antigens, aptamers, glycoproteins, and enzymes, etc. to the SPIONs which are capable of targeting multiple kinds of cancerous sites, have provided stable and functional SPIONs–based nano-carriers suitable for the systemic, and in vitro deliveries, together with being suitable for other biomedical/biotechnical applications. Together with the SPIONs inherent properties, and ability to respond to magnetic resonance, fluorescence-directed, dual-module, and molecular-level tumor imaging; as well as multi-modular cancer cell targeting; magnetic-field-inducible drug-elution capacity, and the SPIONs’ magnetometry-led feasibility to reach cancer action sites have made sensing, imaging, and drug and other payloads deliveries to cancerous sites for cancer treatment a viable option. Innovations in the preparation of SPIONs-based delivery modules, as biocompatible carriers; development of delivery route modalities; approaches to enhancing their drug delivery-cum-bioavailability have explicitly established the SPIONs’ versatility for oncological theranostics and imaging. The current review outlines the development of various SPIONs-based nano-carriers for targeted doxorubicin delivery to different cancer sites through multiple methods, modalities, and materials, wherein high-potential nano-structured platforms have been conceptualized, developed, and tested for, both, in vivo and in vitro conditions. The current state of the knowledge in this arena have provided definite dose-control, site-specificity, stability, transport feasibility, and effective onsite drug de-loading, however, with certain limitations, and these shortcomings have opened the field for further advancements by identifying the bottlenecks, suggestive and plausible remediation, as well as more clear directions for future development.

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“…[3][4][5][6][7] Of all uses, MNPs are exhaustively used as carriers for delivery of different chemotherapeutic drugs via active and passive targeting routes. [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Surface engineered Fe₃O₄ nanomagnets for pH-responsive delivery of gemcitabine hydrochloride and in vivo tracking by radiolabeling

et al. 2023

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Thermal and microwave synthesized SPIONs: Energy effects on the efficiency of nano drug carriers

Cited by 11 publications

References 50 publications

Nanozyme for tumor therapy: Surface modification matters

Nanozyme for tumor therapy: Surface modification matters

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

Surface engineered Fe₃O₄ nanomagnets for pH-responsive delivery of gemcitabine hydrochloride and in vivo tracking by radiolabeling

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Thermal and microwave synthesized SPIONs: Energy effects on the efficiency of nano drug carriers

Cited by 11 publications

References 50 publications

Nanozyme for tumor therapy: Surface modification matters

Nanozyme for tumor therapy: Surface modification matters

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

Surface engineered Fe3O4 nanomagnets for pH-responsive delivery of gemcitabine hydrochloride and in vivo tracking by radiolabeling

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Surface engineered Fe₃O₄ nanomagnets for pH-responsive delivery of gemcitabine hydrochloride and in vivo tracking by radiolabeling