Surface engineered Fe3O4 nanomagnets for pH-responsive delivery of gemcitabine hydrochloride and in vivo tracking by radiolabeling

Dutta, Binay K.; Shelar, Sandeep; Barick, K. C.; Shetty, Priyalata; Chakravarty, Rubel; Chakraborty, Sudipta; Checker, Swati; Sarma, Haladhar Dev; Hassan, P. A.

doi:10.1039/d2ma00647b

Cited by 1 publication

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“…The loading efficiency (w/w %) was determined using the following formula: The encapsulation efficiency was also reconfirmed by the absorbance intensity using a UV−visible spectrophotometer as reported earlier. 10,42 For the release study, drug-loading experiments were performed at an increased scale with a drug-to-particle (expressed in terms of Fe) ratio of 1:14 (w/ w). The drug release studies were carried out in AB pH 5.5 and PBS pH 7.4 at 37 °C under reservoir-sink conditions.…”

Section: Drug Loading and Release Studiesmentioning

confidence: 99%

Smart Magnetic Nanocarriers for Codelivery of Nitric Oxide and Doxorubicin for Enhanced Apoptosis in Cancer Cells

Dutta,

Shelar,

Nirmalraj

et al. 2023

ACS Omega

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Extremely short half-life therapeutic molecule nitric oxide (NO) plays significant roles in the functioning of various physiological and pathological processes in the human body, whereas doxorubicin hydrochloride (DOX) is a clinically important anticancer drug widely used in cancer chemotherapy. Thus, the intracellular delivery of these therapeutic molecules is tremendously important to achieve their full potential. Herein, we report a novel approach for the development of highly water-dispersible magnetic nanocarriers for codelivery of NO and DOX. Primarily, bifunctional magnetic nanoparticles enriched with carboxyl and thiol groups were prepared by introducing cysteine onto the surface of citrate-functionalized Fe 3 O 4 nanoparticles. DOX was electrostatically conjugated onto the surface of bifunctional nanoparticles via carboxyl moieties, whereas the thiol group was further nitrosated to provide NO-releasing molecules. The developed magnetic nanocarrier exhibited good aqueous colloidal stability, protein resistance behavior, and high encapsulation efficacy for NO (65.5%) and DOX (85%), as well as sustained release characteristics. Moreover, they showed superior cytotoxicity toward cancer (A549 and MCF-7) cells via apoptosis induction over normal (WI26VA4) cells. Specifically, we have developed magnetic nanocarriers having the capability of dual delivery of NO and DOX, which holds great potential for combinatorial cancer treatment.

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Section: Drug Loading and Release Studiesmentioning

confidence: 99%

Smart Magnetic Nanocarriers for Codelivery of Nitric Oxide and Doxorubicin for Enhanced Apoptosis in Cancer Cells

Dutta,

Shelar,

Nirmalraj

et al. 2023

ACS Omega

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Surface engineered Fe₃O₄ nanomagnets for pH-responsive delivery of gemcitabine hydrochloride and in vivo tracking by radiolabeling

Abstract: Gemcitabine, a well-known nucleoside analogue has shown tremendous potential against solid tumors. However, its clinical use is limited due to its poor biological half-life and low target to non-target ratio....

Cited by 1 publication

References 40 publications

Smart Magnetic Nanocarriers for Codelivery of Nitric Oxide and Doxorubicin for Enhanced Apoptosis in Cancer Cells

Smart Magnetic Nanocarriers for Codelivery of Nitric Oxide and Doxorubicin for Enhanced Apoptosis in Cancer Cells

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