Thermal Ablation of Tumors Using Magnetic Nanoparticles

Abstract

The data indicate that the proposed method allows the generation of localized heat spots at the tumor area. According to the histologic analysis and previous investigations the DHD were, in principle, high enough to kill tumor cells. The reasons for the presence of regions of temperature underdosage are discussed in the text. Special attention should be paid on the particle wash out in organs in the vicinity of the breast.

Clinical applications of magnetic nanoparticles for hyperthermia

“…Direct injection of dextran-coated magnetite nanoparticles with a core size of approximately 3 nm into tumors was first reported by our group in 1997 [10]. Hilger et al injected colloidal suspensions of coated nanoparticles (particle sizes of 10 nm and 200 nm) into human carcinomas implanted into mice and described 'magnetic thermal ablation' [11]. Ohno et al inserted stick-type carboxymethylcellulose magnetite containing nanoparticles into gliomas and described a three-fold prolongation of survival time [12].…”

Influence of dipolar interactions on hyperthermia properties of ferromagnetic particles

“…1 Since then, in vitro experiments with magnetic fluids have confirmed their excellent power absorption capabilities. 2 In vivo experiments have documented the feasibility of this treatment in animal models of melanoma, 3 breast tumors, 4 and prostate cancer. 5 Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio-or chemotherapy, thus increasing therapeutic efficiency.…”

Dispersed gold nanoparticles potentially ruin gold barley yellow dwarf virus and eliminate virus infectivity hazards

“…Moreover, nanometric building blocks can aid in the survey of the molecularly directed assembly of biomolecular arrays. Hilger et al 2002 add an alternating magnetic field that could also be used to heat the magnetic nanoparticles, thus making hyperthermia treatment of tumors feasible and a potential simultaneous treatment. This strategy of AuNPs application in our study induced by combining virus particles with AuNPs possibly leads to synergistic therapeutic effects for inducing virus resistance by the interaction performances, as illustrated in TEM.…”