Therapy of Metastasis in Animal Models

Pollack, Vincent A.

doi:10.1007/978-94-009-1089-8_18

Cited by 2 publications

(1 citation statement)

References 86 publications

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“…A number of compounds, e.g. anticoagulatnts, platelet inhibitors, or antiinvasive compounds have been identified as potential antimetastatic drugs [3][4][5]. Many of them were able to reduce the number of lung colonies after intravenous injection of tumor cells ("artificial metastasis model"), but the majority failed to inhibit metastasis of spontaneously metastasizing tumors, a model system which covers all steps of the metastatic cascade and therefore has a high relevance to the clinic [4,5].…”

Section: O~002 Hmentioning

confidence: 99%

Antimetastatic action of the prostacyclin analogue cicaprost in experimental mammary tumors

Schneider¹,

Schirner²,

Lichtner³

et al. 1996

Breast Cancer Res Tr

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In breast cancer, the survival rate strongly depends on the number of lymph nodes involved. A drug with a specific inhibitory activity on lymph node and organ metastases would therefore be a candidate for adjuvant therapy after surgery. Prostacyclin and its stable analogues have been shown to interfere with certain steps of the metastatic cascade and to inhibit the number of lung colonies after i.v.-inoculation of various tumor cell lines. Our data reveal that cicaprost, a metabolically stable and orally active analogue of prostacyclin, has pronounced antimetastatic effects in a series of spontaneously metastasizing rodent tumors. In the SMT 2a and 13762 MTLn3 mammary carcinomas of the rat, cicaprost given daily from the day of tumor implantation strongly inhibits the number of lung metastases as well as lymph node weights without exerting an effect on the primary tumor. Even starting treatment when palpable primary tumors are present gives a pronounced antimetastatic activity. To demonstrate that cicaprost has an effect on metastases already settled in the respective organ, treatment was started after surgical removal of the primary tumor. In the SMT 2a tumor, a strong inhibition of the number of metastases was shown. Interestingly, a perioperative treatment schedule was also effective in both models used. As primary tumor growth in vivo or proliferation in vitro remained unchanged by cicaprost, its mode of action seems to be related to one or more mechanisms of the metastatic process. In tumor cell lines expressing a functional prostacyclin receptor, stimulated tumor cell migration is inhibited and changes of differentiation status are obvious. In conclusion, cicaprost strongly inhibits lymph node and organ metastases of spontaneously metastasizing rodent mammary tumors with a mode of action different from cytostatic or antihormonal drugs.

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Section: O~002 Hmentioning

confidence: 99%

Antimetastatic action of the prostacyclin analogue cicaprost in experimental mammary tumors

Schneider¹,

Schirner²,

Lichtner³

et al. 1996

Breast Cancer Res Tr

View full text Add to dashboard Cite

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Metástase, uma visão atualizada

Pitrez

Lemchem

Grossmann

et al. 2023

Rev. Bras. Cancerol.

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Os autores revisam a Cascata Metastática, nome que designa a seqüência de fenômenos que levam à implantação da célula metastática e sua multiplicação no órgão alvo. Através de uma revisão atualizada da literatura pertinente, expõem as múltiplas teorias e experimentos que tentam esclarecer os complexos mecanismos bioquímicos e enzimáticos que envolvem este fascinante processo, bem como sua implicação terapêutica.

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Therapy of Metastasis in Animal Models

Cited by 2 publications

References 86 publications

Antimetastatic action of the prostacyclin analogue cicaprost in experimental mammary tumors

Antimetastatic action of the prostacyclin analogue cicaprost in experimental mammary tumors

Metástase, uma visão atualizada

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