Therapy of Bladder Carcinoma

Hellsten, Sverker; Glifberg, Ingemar; Lindholm, Christer; Telhammar, E.

doi:10.3109/00365598109179586

Cited by 12 publications

(3 citation statements)

References 10 publications

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“…Multiple tumors at diagnosis were seen in 23% of our patients, which is a lower incidence than the 29-30% in other studies (13,15). One possible explanation for the difference may be the inclusion of smaller, papillary low-grade tumors and solitary tumors in our population-based study from 1987-88.…”

Section: Discussioncontrasting

confidence: 64%

“…Consequently, this report describes patient material reflecting the true incidence and distribution of bladder carcinomas in a geographical region. The mean age of the patients (70.5 years) is equal to or slightly higher than the mean age in previous Scandinavian reports (4,5,8,13). These reports mainly comprised unselected patients from the catchment areas of the respective centres.…”

Section: Discussionmentioning

confidence: 62%

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Prospective Registration of all Patients in a Geographical Region with Newly Diagnosed Bladder Carcinomas during a Two-year Period

Holmäng

Hedelin

Anderström

et al. 2000

Scandinavian Journal of Urology and Nephrology

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Differences in mean age, stage and grade distribution were found between the present report, which included all patients with newly diagnosed bladder carcinoma in a geographical area, and other reports, which mainly comprised patients from large treatment centres. These differences can probably and mainly be explained by selection factors such as various degrees of inclusion of low-grade papillary tumors.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 62%

Prospective Registration of all Patients in a Geographical Region with Newly Diagnosed Bladder Carcinomas during a Two-year Period

Holmäng

Hedelin

Anderström

et al. 2000

Scandinavian Journal of Urology and Nephrology

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“…Studies on the predictive significance of the initial grade have been based on the results of surgical management alone (Makinen et al, 1978;Collan et al, 1979;Hellsten et al, 1981;Pavone-Macaluso, 1982;Huland et al, 1984;Kurth et al, 1985). The prognostic importance of the grade can be re-examined in the light of adjuvant instillation prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Instillation of Mitomycin C and Doxorubicin in the Prevention of Recurrent Superficial (Ta—T1) Bladder Cancer

Jauhiainen

Alfthan

1987

British Journal of Urology

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Both Mitomycin C (MMC) and doxorubicin (Adriamycin) (ADM) prevent the recurrence of superficial papillary (Ta-T1) urinary bladder cancers and also reduce the rate of progression. MMC appears to be more effective than ADM in buffered instillations. The number of recurrent tumours (RI/m) and the number of recurrence times (RR) before prophylactic instillation were of significant prognostic importance but the prognostic value of the grade was questionable. The buffer solution, together with methyl prednisolone, reduced the incidence of chemical cystitis.

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The grade and pathologic stage of bladder cancer

Kern

1984

Cancer

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One hundred fourteen cases of bladder cancers treated during a 3‐year period by cystectomy were uniformly reclassified, graded, and pathologically staged. One hundred thirty‐one cases treated during the same period by transurethral or segmental resection were similarly reclassified and checked for muscle invasion. Sixty‐one percent of the cystectomy cases were nonpapillary and 69% of the conservatively treated cases were papillary transitional cell carcinomas. In the pathologically staged cystectomy group, all poorly differentiated (grade III and IV) carcinomas were invasive. Nonpapillary tumors were more aggressive and 79% of the high grade tumors in these categories extended into the outer portions of the muscularis or into perivesical tissues. Muscle invasion could also be demonstrated in 74% of the 23 high‐grade nonpapillary carcinomas in the conservatively treated cases. Lymph node and pelvic wall metastases were found in 17% of the cystectomies and were present only in tumor grades III and IV and a pathologic stage of P‐3B or higher. None of the well differentiated (grade I) papillary carcinomas were invasive and invasion was superficial in most moderately differentiated (grade II) papillary tumors. The findings confirm that pathologic classification and grading of bladder carcinomas correlate closely with the stage of the disease. Cancer 53:1185‐1189, 1984.

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Therapy of Bladder Carcinoma

Cited by 12 publications

References 10 publications

Prospective Registration of all Patients in a Geographical Region with Newly Diagnosed Bladder Carcinomas during a Two-year Period

Prospective Registration of all Patients in a Geographical Region with Newly Diagnosed Bladder Carcinomas during a Two-year Period

Instillation of Mitomycin C and Doxorubicin in the Prevention of Recurrent Superficial (Ta—T1) Bladder Cancer

The grade and pathologic stage of bladder cancer

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