Prospective Registration of all Patients in a Geographical Region with Newly Diagnosed Bladder Carcinomas during a Two-year Period

Holmäng, Sten; Hedelin, Hans; Anderström, Claes; Holmberg, Erik; Johansson, Sonny L.

doi:10.1080/003655900750016698

Cited by 25 publications

(14 citation statements)

References 23 publications

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“…to arsenic, but this requires further investigation. It is conceivable, although unlikely, that the similarity of the results to those of Holmäng et al [14,28] from Scandinavia could in part be related to similar ethnic mix, levels of industrialization, lifestyle or other demographic characteristics, rather than to the population-based character of the study population. Future analyses to evaluate potential histological patterns associated with exposure history may provide helpful etiological clues.…”

Section: Discussionmentioning

confidence: 47%

“…The present findings suggest that the distribution of tumor types may vary by gender and age, and thus the demographics of the selected referral population could affect the distribution of tumor types. Table III compares pathological stage distribution between the present population-based study and representative previously reported studies [8][9][10][11][12][13][14]21,22], all but one of which [14] were based on selected, hospital-or clinic-based patient populations. The hospital-or clinic-based series show a range of non-invasive (stage pTa) tumors between 30 and 49%, compared with 66% in this population-based sample.…”

Section: Discussionmentioning

confidence: 98%

“…The published diagnostic criteria of the WHO/ISUP classification system, however, have been profusely illustrated and described in unusual detail; this was done expressly to reduce diagnostic variability and subjectivity [18,19]. Also, the similarity of the data to those of other studies with a populationbased design [14,23,28] suggests similar application of diagnostic criteria. In addition, internal checks for intraobserver variability supported the intrastudy stability of diagnoses.…”

Section: Discussionmentioning

confidence: 99%

“…In the present data, no marked differences in histological characteristics by age were detected. In another study, the mean age at diagnosis of a stage T2 cancer was 75 years [14], while the mean ages for Ta and T1 tumors were 70 and 73 years, respectively. Thus, the possibility cannot be excluded that omission of cases in patients older than 74 years in the current study could have led to an underestimation of advanced (stage 2 or greater) disease.…”

Section: Discussionmentioning

confidence: 99%

“…Such studies are likely to include a disproportionate number of patients with more aggressive or advanced stage tumors. Only a small number of non-selected, population-based studies of bladder cancer have reported grade and stage data, primarily from Scandinavia [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States

Schned

Andrew

Marsit

et al. 2008

Scandinavian Journal of Urology and Nephrology

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Objective-There are limited data on the distribution of bladder cancers in the general population, classified by World Health Organization (WHO)/International Society of Urological Pathology (ISUP) criteria. This study evaluated the classification and stage of bladder cancers as part of a population-based epidemiological study of bladder cancer in the Northeastern United States.Material and methods-All New Hampshire residents with bladder cancer newly diagnosed from 1998 to 2000 were identified through the state cancer registry. All slides were reviewed by a single pathologist. Tumors were classified by two sets of standard criteria.Results-The retrieval rate for cases was over 90%. Of 342 cases reviewed, 15 were excluded for technical reasons or because malignancy was not definitively diagnosed. According to WHO/ISUP criteria, 25.7% of tumors were papillary urothelial neoplasms of low malignant potential (PUNLMP), 34.3% low-grade papillary carcinomas, 22.6% high-grade papillary carcinomas, 10.1% non-papillary urothelial carcinomas and 5.5% carcinoma in situ. By WHO (1973) criteria, 52.5% of tumors were grade 1, 21.4% grade 2 and 26.1% grade 3. Two-thirds of all tumors were stage Ta, 20.8% stage T1 and 7.6% stage ≥T2. 100% of PUNLMPs were non-invasive, 6.3% of low-grade carcinomas were invasive and 64.9% of high-grade carcinomas were invasive.Conclusions-Compared to clinic or hospital referral-based series, this study documents a higher percentage of non-invasive tumors and a lower percentage of muscle-invasive tumors. There was also a higher percentage of PUNLMP tumors and fewer high-grade papillary carcinomas than in other series. These results may more accurately reflect prevalence data for bladder cancer grade and stage, although geographic variability may exist.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States

Schned

Andrew

Marsit

et al. 2008

Scandinavian Journal of Urology and Nephrology

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Motility‐related protein 1 (MRP‐1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progression

Mhawech

Herrmann

Coassin

et al. 2003

Cancer

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BACKGROUND: CD9 has been implicated in cell adhesion, motility, and proliferation, and numerous studies have demonstrated its prognostic value in different solid tumors. The objective of this study was to determine the relation of CD9 expression to tumor grade and tumor stage of urothelial carcinoma of the bladder and to define the value of CD9 in predicting the behavior of superficial papillary tumors (SPTs) (pathologic Ta [pTa] and pT1). METHODS: Three hundred twenty patients (118 patients with pTa tumors, 111 patients with pT1 tumors, and 91 patients with pT2 tumors) were examined for CD9 expression using immunohistochemistry applied on formalin fixed, paraffin embedded tissue. Patients were stratified into 3 categories, depending on CD9 expression: positive (> 50% positive cells), reduced (5-50% positive cells), or negative (< 5% positive cells). RESULTS: Loss of CD9 expression was found to be associated significantly with high-grade and high-stage urothelial tumors (P < 0.0001). A reduced/negative (altered) CD9 expression was associated with SPT progression, but not with recurrence (P < 0.001). Patients who had pTa or pT1 tumors with altered CD9 expression had a relative risk of 5.59 (P = 0.005; 95% confidence interval [95% CI], 1.69-18.48) for progression compared with patients who had tumors with positive CD9 expression. Kaplan-Meier curves showed that a lack of CD9 expression was associated significantly with progression free survival (P < 0.001; log-rank test), but not with recurrence. In patients with SPTs, multivariate Cox proportional hazards regression analysis revealed that negative CD9 expression was an independent prognostic marker for the prediction of tumor progression (P = 0.007; 95% CI, 0.11-0.70). CONCLUSIONS: In patients with urothelial bladder carcinoma, CD9 expression was associated significantly with tumor stage and grade, and a loss of CD9 expression was an independent prognostic factor for predicting progression in patients with SPTs. Thus, CD9 immunoexpression is a potential new predictor of tumor behavior in patients with SPTs of the urinary bladder. Cancer 2003

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Lymph node assessment and lymphadenectomy in bladder cancer

Sharir

Fleshner

2009

Journal of Surgical Oncology

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Lymph node status is a key prognostic indicator in patients with bladder cancer, so lymphadenectomy is important for accurate staging. Moreover, lymphadenectomy is curative for some patients with nodal metastases. Although there is evidence that the quality of regional node dissection is associated with oncologic outcome, controversy exists because other factors may also explain this observation. Consequently, there is no consensus regarding the optimal extent of lymphadenectomy and number of nodes that should be assessed.

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Prospective Registration of all Patients in a Geographical Region with Newly Diagnosed Bladder Carcinomas during a Two-year Period

Cited by 25 publications

References 23 publications

Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States

Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States

Motility‐related protein 1 (MRP‐1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progression

Lymph node assessment and lymphadenectomy in bladder cancer

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