Therapy-induced shaping of the glioblastoma microenvironment: Macrophages at play

Erbani, Johanna; Boon, Menno; Akkari, Leila

doi:10.1016/j.semcancer.2022.05.003

Cited by 13 publications

(6 citation statements)

References 199 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, these TAMs were located around blood vessels and perinecrotic areas, where a protumoral interaction with GSCs is postulated [ 85 ]. Perivascular TAMs (with a more M2 phenotype) are proangiogenic and protumoral, because they present a variety of markers such as VEGFA, CCR2, and Tie2 [ 86 ]. It has been reported that microglia/macrophages cells present proangiogenic factors such as CXCL2 and CD13 that act independently of VEGF.…”

Section: Macrophages Functions In Malignant Gliomasmentioning

confidence: 99%

Exploring Monocytes-Macrophages in Immune Microenvironment of Glioblastoma for the Design of Novel Therapeutic Strategies

et al. 2023

View full text Add to dashboard Cite

Gliomas are primary malignant brain tumors. These tumors seem to be more and more frequent, not only because of a true increase in their incidence, but also due to the increase in life expectancy of the general population. Among gliomas, malignant gliomas and more specifically glioblastomas (GBM) are a challenge in their diagnosis and treatment. There are few effective therapies for these tumors, and patients with GBM fare poorly, even after aggressive surgery, chemotherapy, and radiation. Over the last decade, it is now appreciated that these tumors are composed of numerous distinct tumoral and non-tumoral cell populations, which could each influence the overall tumor biology and response to therapies. Monocytes have been proved to actively participate in tumor growth, giving rise to the support of tumor-associated macrophages (TAMs). In GBM, TAMs represent up to one half of the tumor mass cells, including both infiltrating macrophages and resident brain microglia. Infiltrating macrophages/monocytes constituted ~ 85% of the total TAM population, they have immune functions, and they can release a wide array of growth factors and cytokines in response to those factors produced by tumor and non-tumor cells from the tumor microenvironment (TME). A brief review of the literature shows that this cell population has been increasingly studied in GBM TME to understand its role in tumor progression and therapeutic resistance. Through the knowledge of its biology and protumoral function, the development of therapeutic strategies that employ their recruitment as well as the modulation of their immunological phenotype, and even the eradication of the cell population, can be harnessed for therapeutic benefit. This revision aims to summarize GBM TME and localization in tumor niches with special focus on TAM population, its origin and functions in tumor progression and resistance to conventional and experimental GBM treatments. Moreover, recent advances on the development of TAM cell targeting and new cellular therapeutic strategies based on monocyte/macrophages recruitment to eradicate GBM are discussed as complementary therapeutics.

show abstract

Section: Macrophages Functions In Malignant Gliomasmentioning

confidence: 99%

Exploring Monocytes-Macrophages in Immune Microenvironment of Glioblastoma for the Design of Novel Therapeutic Strategies

et al. 2023

View full text Add to dashboard Cite

show abstract

“…3 Tumor-associated macrophages interact with tumor cells and facilitate proliferation, chemoresistance, distance metastasis, and survival of tumor cells. 3 In addition, TAMs contribute to the development of immunosuppressive TME by producing cytokines and chemokines and triggering the exhaustion of T cells. 4 Emerging evidence indicates that altered signaling pathways and metabolic properties support the tumorigenic functions of TAMs.…”

Section: Introductionmentioning

confidence: 99%

“…It is well documented that TAMs play a tumor‐promoting role in the growth and invasion of cancer primary and metastatic sites and high TAM levels correlate with aggressive cancer phenotype and disease progression in various types of human cancer 3 . Tumor‐associated macrophages interact with tumor cells and facilitate proliferation, chemoresistance, distance metastasis, and survival of tumor cells 3 . In addition, TAMs contribute to the development of immunosuppressive TME by producing cytokines and chemokines and triggering the exhaustion of T cells 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Tumor‐associated macrophages are one of the most abundant immunosuppressive innate immune cell populations in the TME 2 . It is well documented that TAMs play a tumor‐promoting role in the growth and invasion of cancer primary and metastatic sites and high TAM levels correlate with aggressive cancer phenotype and disease progression in various types of human cancer 3 . Tumor‐associated macrophages interact with tumor cells and facilitate proliferation, chemoresistance, distance metastasis, and survival of tumor cells 3 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

SLC3A2 promotes tumor‐associated macrophage polarization through metabolic reprogramming in lung cancer

Chen

et al. 2023

Cancer Science

View full text Add to dashboard Cite

Tumor-associated macrophages (TAMs) are one of the most abundant immunosuppressive cells in the tumor microenvironment and possess crucial functions in facilitating tumor progression. Emerging evidence indicates that altered metabolic properties in cancer cells support the tumorigenic functions of TAMs.However, the mechanisms and mediators the underly the cross-talk between cancer cells and TAMs remain largely unknown. In the present study, we revealed that high solute carrier family 3 member 2 (SLC3A2) expression in lung cancer patients was associated with TAMs and poor prognosis. Knockdown of SLC3A2 in lung adenocarcinoma cells impaired M2 polarization of macrophages in a coculture system. Using metabolome analysis, we identified that SLC3A2 knockdown altered the metabolism of lung cancer cells and changed multiple metabolites, including arachidonic acid, in the tumor microenvironment. More importantly, we showed that arachidonic acid was responsible for SLC3A2-mediated macrophage polarization in the tumor microenvironment to differentiate into M2 type both in vitro and in vivo. Our data illustrate previously undescribed mechanisms responsible for TAM polarization and suggest that SLC3A2 acts as a metabolic switch on lung adenocarcinoma cells to induce macrophage phenotypic reprogramming through arachidonic acid.

show abstract

“…Tumor microenvironment (TME) is constructed by interacting closely with the extracellular matrix (ECM) and stromal cells to evade detection and eradication by host immune surveillance ( Ge and Ding, 2020 ). Mounting studies have indicated the composition of the TME correlates strongly with immune response and chemotherapy, and regulations in various immune cells from the TME effect the clinical outcome of malignancies ( Erbani et al, 2022 ; Friedrich et al, 2022 ; Pang et al, 2022 ; Wang et al, 2022 ). Tumor-associated macrophages (TAM) drive tumor progression, metastasis, and therapeutic resistance ( Larroquette et al, 2022 )but heterogeneity is a considerable factor in macrophages ( Wu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical value of M1 macrophage-related genes identification in bladder urothelial carcinoma and in vitro validation

Huang

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Background: Tumor microenvironment (TME) takes a non-negligible role in the progression and metastasis of bladder urothelial carcinoma (BLCA) and tumor development could be inhibited by macrophage M1 in TME. The role of macrophage M1-related genes in BLCA adjuvant therapy has not been studied well.Methods: CIBERSOR algorithm was applied for identification tumor-infiltrating immune cells (TICs) subtypes of subjects from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data sets. We identified potential modules of M1 macrophages by weighted gene co-expression network analysis (WGCNA). Nomogram was determined by one-way Cox regression and lasso regression analysis for M1 macrophage genes. The data from GEO are taken to verify the models externally. Kaplan-Meier and receiver operating characteristic (ROC) curves validated prognostic value of M1 macrophage genes. Finally, we divided patients into the low-risk group (LRG) and the high-risk group (HRG) based on the median risk score (RS), and the predictive value of RS in patients with BLCA immunotherapy and chemotherapy was investigated. Bladder cancer (T24, 5637, and BIU-87) and bladder uroepithelial cell line (SV-HUC-1) were used for in vitro validation. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was employed to validate the associated genes mRNA level.Results: 111 macrophage M1-related genes were identified using WGCNA. RS model containing three prognostically significant M1 macrophage-associated genes (FBXO6, OAS1, and TMEM229B) was formed by multiple Cox analysis, and a polygenic risk model and a comprehensive prognostic line plot was developed. The calibration curve clarified RS was a good predictor of prognosis. Patients in the LRG were more suitable for programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte associate protein-4 (CTLA4) combination immunotherapy. Finally, chemotherapeutic drug models showed patients in the LRG were more sensitive to gemcitabine and mitomycin. RT-qPCR result elucidated the upregulation of FBXO6, TMEM229B, and downregulation of OAS1 in BLCA cell lines.Conclusion: A predictive model based on M1 macrophage-related genes can help guide us in the treatment of BLCA.

show abstract

Therapy-induced shaping of the glioblastoma microenvironment: Macrophages at play

Cited by 13 publications

References 199 publications

Exploring Monocytes-Macrophages in Immune Microenvironment of Glioblastoma for the Design of Novel Therapeutic Strategies

Exploring Monocytes-Macrophages in Immune Microenvironment of Glioblastoma for the Design of Novel Therapeutic Strategies

SLC3A2 promotes tumor‐associated macrophage polarization through metabolic reprogramming in lung cancer

Clinical value of M1 macrophage-related genes identification in bladder urothelial carcinoma and in vitro validation

Contact Info

Product

Resources

About