Therapies in Canine Atopic Dermatitis

Santoro, Domenico

doi:10.1016/j.cvsm.2018.08.002

Cited by 47 publications

(52 citation statements)

References 86 publications

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“…In particular, pyoderma is a pyogenic infection that can affect epidermis and hair follicle units or dermis and subjacent fatty tissue. Atopic dermatitis is a genetically predisposed inflammatory and pruritic allergic skin disease in which the skin microbiome may cause secondary infections that can influence its severity [1,2]. In both cases, Staphylococci are the most frequently involved agents: S. pseudointermedius is considered the primary canine cutaneous pathogen, but other Staphylococcus species may be found in skin infection, as well as Escherichia coli, Proteus spp., and Pseudomonas spp.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Essential Oils against Staphylococcus and Malassezia Strains Isolated from Canine Dermatitis

et al. 2020

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Staphylococcus spp. bacteria are the most frequently involved agents in canine cutaneous infections. Treatment of these infections is based on antibiotic therapy, that often is not effective because of the antibiotic-resistance of the bacterial strains. Cutaneous staphylococcal infections are often complicated by Malassezia yeasts, that may be resistant to the conventional antifungal drugs. The present investigation was aimed to evaluate the in vitro antimicrobial activity of some essential oils (EOs) in view of a potential cutaneous application. In detail, EOs obtained from lemon verbena (Aloysia triphylla L’Hèr. Britton), cinnamon (Cinnamomum zeylanicum J. Presl), myrrh (Commiphora myrrha (Nees) Engl. var. molmol), lemongrass (Cymbopogon citratus (DC.) Stapf), litsea (Litsea cubeba (Lour.) Pers.), lemon balm (Melissa officinalis L.), oregano (Origanum vulgare L.), savory (Satureja montana L.), and thyme (Thymus vulgaris L.) were assayed against Staphylococcus spp. and Malassezia pachydermatis strains previously isolated from dogs with dermatitis. All EOs were tested by agar disk diffusion and minimum inhibitory concentration methods to verify the antistaphylococcal activity, and by a microdilution method to evaluate the activity against M. pachydermatis. O. vulgare, T. vulgaris, and S. montana showed the best antibacterial activity against all the selected strains, with MICs ranging from 0.29 to 0.58 mg/mL, from 0.58 to 1.16 mg/mL, and from 0.56 to 1.12 mg/mL, respectively, whereas A. triphylla (1.03 mg/mL) and S. montana (1.8 mg/mL) were the most active against M. pachydermatis. After a proper in vivo evaluation, O. vulgare, T. vulgaris, and S. montana EOs could be a promising treatment to combat canine cutaneous mixed infections.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Essential Oils against Staphylococcus and Malassezia Strains Isolated from Canine Dermatitis

et al. 2020

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“…In these cases, although patients present the same clinical signs of CAD, an IgE response to environmental or other allergens cannot be documented [ 4 ]. The real incidence of CAD-like is unknown [ 45 ]. In a retrospective study, Prelaud and Cochet-Faivre have obtained a CAD-like incidence percentage of 25.6%.…”

Section: Discussionmentioning

confidence: 99%

Detection of Serum Allergen-Specific IgE in Atopic Dogs Tested in Northern Italy: Preliminary Study

Tommaso

Luciani

Crisi

et al. 2021

Animals

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Canine atopic dermatitis (CAD) is a pruritic allergic skin disease associated with IgE-mediated hypersensitivity. IgE is detected using Serum Allergen-Specific IgE test (SAT) in order to identify allergens. The present study aims to identify the environmental allergens in atopic dogs living in Northern Italy using SAT. The screening SAT (sSAT), using a monoclonal antibody cocktail-based ELISA to identify indoor and outdoor allergens, was performed. In all positive samples, an anti-IgE monoclonal antibody ELISA test was performed to extend panel of allergens. Out of 117 selected dogs, 69 were included in the study; 71% were positive and 29% were negative to sSAT. Among the 49 positive sSAT, 53% were positive for both indoor and outdoor, 38.8% only for indoor, and 8.2% only for outdoor allergens. This is the first study on the frequency of allergens involved in CAD in Italy using SAT. IgE hypersensitivity in atopic dogs of Northern Italy is usually associated with indoor allergens, primarily house dust mites. Among the outdoor allergens, an important role was played by Rumex acetosa. Polysensitization also commonly occurs. Therefore, since the numerous factors affect the IgE positivity in CAD, specific panels for geographical areas should be considered and re-evaluated at time intervals.

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“…Because of the diversity of the phenomena involved in the development of cAD and the different clinical aspects, a supplementary rational and personalized therapeutic approach is necessary for each patient. Chronic skill inflammation, persistent skin infections and pruritic manifestations are the clinical aspects of cAD( Santoro, 2019). It was observed, in particular as clinical usual signs a general pruritus accompanied by erythema, papules, pustules, crusts and excoriations (Hensel, Santoro, Favrot, Hill, & Griffin, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Four are the principal factors regarding cAD treatment; in particular: time, inflammation, pruritus and finally infections. Both chronicity and severity of lesions establish the choice of short‐term or long‐term medications, considering also efficacy, side effects and related costs (Santoro, 2019). The therapeutic approach should be modified for every atopic animal, respecting the needs of each dog and the dog's owners.…”

Section: Discussionmentioning

confidence: 99%

Canine atopic dermatitis: Role of luteolin as new natural treatment

Gugliandolo

Palma

Cordaro

et al. 2020

Veterinary Medicine & Sci

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Background Luteolin has been demonstrated to possess numerous biological effects. However, the effect of luteolin on LPS (Lipopolysaccharides) stimulation in CPEK cells has not been investigated. Hypothesis/Objectives An in vitro model of atopic canine dermatitis was used to identify the antioxidant effect of luteolin as a new treatment that is capable of improving the conditions of veterinary patients. Methods CPEK cells were treated with or without luteolin in the presence or absence of LPS. A cell viability assay was performed to test luteolin toxicity and the protective effect of luteolin after LPS stimulation. Additionally, enzyme‐linked immunosorbent assay (ELISA) kits were used to detect the levels of IL‐33, IL‐1β, IL‐6, and IL‐8. Results Luteolin was capable to significantly decrease levels expression of IL‐33, IL 1β, IL‐6, and IL‐8. Conclusions and clinical importance Luteolin could be a new pharmacological treatment for canine atopic dermatitis.

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Therapies in Canine Atopic Dermatitis

Cited by 47 publications

References 86 publications

Antimicrobial Activity of Essential Oils against Staphylococcus and Malassezia Strains Isolated from Canine Dermatitis

Antimicrobial Activity of Essential Oils against Staphylococcus and Malassezia Strains Isolated from Canine Dermatitis

Detection of Serum Allergen-Specific IgE in Atopic Dogs Tested in Northern Italy: Preliminary Study

Canine atopic dermatitis: Role of luteolin as new natural treatment

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