Canine atopic dermatitis: Role of luteolin as new natural treatment

Gugliandolo, Enrico; Palma, Ernesto; Cordaro, Massimiliano; D’Amico, Ramona; Peritore, Alessio Filippo; Licata, Patrizia; Crupi, Rosalia

doi:10.1002/vms3.325

Cited by 13 publications

(11 citation statements)

References 43 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…93 In addition, in the proliferative canine keratinocyte cell line CPEK, luteolin down modulated expression of IL-33, IL-1β, IL-6 and IL-8 after lipopolysaccharide (LPS) stimulation, indicating that luteolin might also enable the treatment of canine atopic dermatitis. 94 Interestingly, luteolin as the active component of Perilla frutescens L. (Lamiaceae) was also shown to inhibit the production of IL-4 in a house dust mite (HDM) induced murine Balb/c model of allergic rhinitis. This was also seen in mononuclear cells from peripheral blood of allergic rhinitis patients restimulated with HDM.…”

Section: Contact Dermatitis and Atopic Dermatitismentioning

confidence: 99%

“…In addition, the major active compound of the EtOH extract, luteolin 7‐O‐glucoside, decreased serum IgE and IL‐4 levels, epidermal thickening as well as transepidermal water loss and increased skin hydration, therefore, showing strong anti‐atopic dermatitis activity 93 . In addition, in the proliferative canine keratinocyte cell line CPEK, luteolin down modulated expression of IL‐33, IL‐1β, IL‐6 and IL‐8 after lipopolysaccharide (LPS) stimulation, indicating that luteolin might also enable the treatment of canine atopic dermatitis 94 …”

Section: Inflammatory Skin Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Luteolin as a modulator of skin aging and inflammation

et al. 2020

View full text Add to dashboard Cite

Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables and spices. It plays an important role in defending plants, for example against UV radiation by partially absorbing UVA and UVB radiation. Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti-oxidative and anti-inflammatory activities of luteolin were described on keratinocytes and fibroblasts as well as on several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic cells and T cells). Luteolin can suppress proinflammatory mediators (e.g., IL-1β, IL-6, IL-8, IL-17, IL-22, TNF-α and COX-2) and regulate various signaling pathway (e.g., the NF-κB, JAK-STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin. The present review summarizes the recent in vitro and in vivo research on luteolin in the field of skin aging and skin cancer, wound healing as well as inflammatory skin diseases, including psoriasis, contact dermatitis and atopic dermatitis.In conclusion, luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases.

show abstract

Section: Contact Dermatitis and Atopic Dermatitismentioning

confidence: 99%

Section: Inflammatory Skin Diseasesmentioning

confidence: 99%

Luteolin as a modulator of skin aging and inflammation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…66,67 Although both anti-inflammatory and anti-oxidant activities do not always coexist in the same molecules, their coexistence is fortuitously common in bioflavonoids such as luteolin in particular. [68][69][70] These activities are intrinsically linked to the multitude of other bioactivities such as anti-allergenic actions 66 as demonstrated in a cell model of canine atopic dermatitis in which luteolin significantly inhibited the release of IL-33, IL-1β, IL-6, and IL-8 71 and in human allergic rhinitis, 72 which is probably mediated by IL-4 inhibition, which in turn suppresses the expression of the ANO1 calcium-activated Cl − channel, which is linked to nasal hypersecretion. Luteolin has also been shown to alleviate rheumatoid arthritis, a serious tumor necrosis factor-α (TNF-α) mediated autoimmune disease.…”

Section: Luteolin Modulation Of Systemic Inflammationmentioning

confidence: 99%

Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis

Daily¹,

Kang

Park

2020

BioFactors

View full text Add to dashboard Cite

Luteolin is a widely distributed flavone herbs and vegetables. It has antioxidant and anti-inflammatory activities and improves glucose metabolism by potentiating insulin sensitivity and improving β-cell function and mass.Alzheimer's disease (AD) is induced by the deposition of amyloid-beta (Aβ) in the hippocampus and the formation of neurotoxic Aβ plaques. The Aβ deposition is associated with increased formation of Aβ from amyloid precursor protein by up-regulation of β-secretase and β-site amyloid precursor proteincleaving enzyme 1 (BACE1). Furthermore, Aβ accumulation is increased by brain insulin resistance. The impairment of insulin/IGF-1 signaling mainly in the hippocampus and brain insulin resistance is connected to signals originating in the liver and gut microbiota, known as the gut microbiota-liver-brain axis. This indicates that the changes in the production of short-chain fatty acids by the gut microbiota and pro-inflammatory cytokines can alter insulin resistance in the liver and brain. Luteolin is detected in the brain tissues after passing through the blood-brain barrier, where it can directly influence neuroinflammation and brain insulin resistance and modulate Aβ deposition. Luteolin (10-70 mg/kg bw for rodents) can modulate the systemic and brain insulin resistance, and it suppresses AD development directly, and it influences Aβ deposition by activation of the gut microbiota-liver-brain axis. In this review, we evaluate the potential of luteolin to mitigate two potential causes of AD, neuroinflammatory processes, and disruption of glucose metabolism in the brain. This review suggests that luteolin intake can enhance brain insulin resistance and neuroinflammation, directly and indirectly, to protect against the development of Alzheimer's-like disease, and the gut microbiota-liver-

show abstract

“…In this regard, ccl2 expression was inhibited in human keratinocytes and skin treated with polyphenols in vitro and in vivo ( 42 , 43 ); in murine monocyte cell lines, ccl2 blunting was observed after the luteolin treatment ( 44 ) and furthermore, piceatannol and cannabidiol are both capable of inhibiting ccl2 expression in activated macrophages in vitro ( 45 , 46 ). The ability of polyphenols and cannabidiol to modulate Th2 response mediators ( 47 , 48 ), including CCL17 and TSLP in AD models ( 49 , 50 ), is equally well-known. Nutraceutical effects on both Th1/Th2 inflammatory mediators are uncommon, especially in dogs, whereas this represents a target for treating inflammatory stress and allergies in humans ( 51 – 53 ).…”

Section: Discussionmentioning

confidence: 99%

Polyphenols and Cannabidiol Modulate Transcriptional Regulation of Th1/Th2 Inflammatory Genes Related to Canine Atopic Dermatitis

Massimini¹,

Vedove²,

Bachetti³

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

Canine atopic dermatitis (AD) is a multifactorial allergic disease associated with immune and abnormal skin barrier dysfunction and it is one of the primary causes of pruritus. Using a novel in vitro model of AD, here we tried to revert the alteration of transcriptional regulation of AD canine key genes testing a nutraceutical mixture containing flavonoids, stilbene, and cannabinoids, which are already well-known for their applications within dermatology diseases. The nutraceutical mixture induced in inflamed cells a significant downregulation (p < 0.05) of the gene expression of ccl2, ccl17, and tslp in keratinocytes and of ccl2, ccl17, and il31ra in monocytes. Consistent with the observed alterations of tslp, ccl2, ccl17, and il31ra messenger RNA (mRNA) levels, a significant increase (p < 0.05) of DNA methylation at specific CpG sites on the gene regulatory regions was found. These results lay the foundation for the use of these natural bioactives in veterinary medicine and provide a model for deeper understanding of their mechanisms of action, with potential translation to human research.

show abstract

Canine atopic dermatitis: Role of luteolin as new natural treatment

Cited by 13 publications

References 43 publications

Luteolin as a modulator of skin aging and inflammation

Luteolin as a modulator of skin aging and inflammation

Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis

Polyphenols and Cannabidiol Modulate Transcriptional Regulation of Th1/Th2 Inflammatory Genes Related to Canine Atopic Dermatitis

Contact Info

Product

Resources

About