Therapies for the treatment of onychomycosis

Small scale trial of photodynamic treatment of onychomycosis in São Paulo

“…This is clearly not the case with conventional therapeutics: although oral antifungal therapy must be prescribed and thus requires the involvement of medical personnel, administrative regimens are often extensive and prolonged, requiring up to sixteen weeks' oral administration. In addition, significant side effects have been reported during terbinafine self-administration, including liver damage, taste and smell disturbances and depressive symptoms [9].…”

Fungal Infections From Human and Animal Contact

“…6,35,39 As noted above for terbinafine Itraconazole (200 mg per day for 12 weeks) also may be used for toenails, particularly for candidal and nondermatophyte mold infections. 39 Topical alternatives: efinaconazole 10% solution daily for 48 weeks (adults, toenails). 40 Ingrowing toenail (2.2%), dermatitis (2.1%), vesicles (1.5%).…”

“…36 May have best success with distal subungual type and when upper nail surface is filed or is otherwise more easily penetrated. 6,38,39 Tavaborole 5% solution daily for 48 weeks (adults, toenails). 41 Ingrowing toenail (2.2%), exfoliation (2.7%), erythema (1.6%), dermatitis (1.3%).…”

Treatment of dermatophyte toenail onychomycosis with itraconazole

“…12 Gupta et al attained mycological cure by 88.2% and clinical cure by 52.9% in patients of toenail onychomycosis caused by dermatophytes treated with itraconazole pulse therapy. 13 They also observed itraconazole pulse therapy effective and safe in people with diabetes. 14 Vora et al recorded cure rate of 40% with itraconazole in the treatment of onychomycosis.…”