Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions

Li, Song; Dong, Jie; Cheng, Cheng; Le, Weidong

doi:10.1007/s00702-016-1603-9

Cited by 44 publications

(29 citation statements)

References 214 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Non-motor symptoms like sleep problems, depression and loss of smell have recently gained an increased attention and were included among the diagnostic criteria [21]. Although PD has been extensively researched since its discovery by James Parkinson in 1817, the exact etiology and pathogenesis that underlie dopaminergic cell death are still unclear [11]. However, numerous epidemiological studies revealed that there is a strong association between sporadic PD which represents more than 90% of PD cases and environmental factors such as environmental toxins, pesticides and heavy metals [9].…”

Section: Introductionmentioning

confidence: 99%

Neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture

Radad¹,

Al‐Shraim²,

Al-Emam³

et al. 2018

View full text Add to dashboard Cite

Introduction: Domoic acid is a potent marine neurotoxin produced by certain species of the diatom genus Pseudonitzschia. To our knowledge, there are no studies that have investigated neurotoxic effects of domoic acid on dopaminergic neurons. Accordingly, the present study was carried out to investigate the potential neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture. Material and methods: Cultures prepared from embryonic mouse mesencephala (total of 250 embryos) were treated with different concentrations of domoic acid (0.1, 1, 10, 100 µM) on the 10 th DIV for 48 h. On the 12 th DIV, culture media were used for measurement of lactate dehydrogenase and cultured cells were subjected to immunostaining for tyrosine hydroxylase, neuronal nuclear antigen and glial fibrillary acidic protein, and fluorescence staining using H 2 DCFDA, JC-1 and DAPI stains. Moreover, roles of AMPA/KA and NMDA receptors in domoic acid neurotoxicity were also investigated. Results: Domoic acid significantly decreased the number of dopaminergic neurons, decreased the expression of neuronal nuclear antigen and slightly affected astrocyte populations, and increased the release of lactate dehydrogenase into the culture media. AMPA/KA receptor antagonist NBQX but not NMDA receptor antagonist MK-801 significantly inhibited the neurotoxic effect of domoic acid on dopaminergic neurons. H 2 DCFDA, JC-1 and DAPI fluorescence staining, respectively, revealed that DomA slightly raised ROS production, and significantly decreased mitochondrial membrane potential and increased apoptotic cell death of cultured cells. Conclusion: The current study presents for the first time the neurotoxic effects of domoic acid on dopaminergic neurons and this effect appears to be attributed to activation of AMPA/KA receptors on dopaminergic neurons.

show abstract

Section: Introductionmentioning

confidence: 99%

Neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture

Radad¹,

Al‐Shraim²,

Al-Emam³

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Current pharmacological treatments for PD are symptomatic and associated with various side effects. Accumulating evidence has revealed the anti‐ageing and neuroprotective effects of natural products from traditional medicines, which may provide alternative therapies for neurodegenerative disorders including PD (Shen et al , ; Kim et al , ; Li et al , ; Islam et al , ; Solanki et al , ; Sun et al , ). Because targeting ALP has recently proposed as a promising strategy for PD and other neurodegenerative diseases (Menzies et al , ), the protective effects of genetically or pharmacologically activated ALP have been tested in experimental models of PD in recent years.…”

Section: Resultsmentioning

confidence: 99%

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

et al. 2017

View full text Add to dashboard Cite

The autophagy-lysosome pathway (ALP) is a primary means by which damaged organelles and long-lived proteins are removed from cells and their components recycled. Impairment of the ALP has been found to be linked to the pathogenesis of Parkinson's disease (PD), a chronic neurodegenerative disorder characterized by the accumulation of protein aggregates and loss of dopaminergic neurons in the midbrain. In recent years, some active compounds derived from plants have been found to regulate the ALP and to exert neuroprotective effects in experimental models of PD, raising the possibility that autophagy enhancement may be an effective therapeutic strategy in PD treatment. In this review, we summarize recent findings of natural products that enhance ALP and thereby protect against PD. Research articles were retrieved from PubMed using relevant keywords in combination. Papers related to the topic were identified, and then the reliability of the experiments was assessed in terms of methodology. The results suggest that targeting the ALP with natural products is a promising strategy for PD treatment. However, risk of bias exists in some studies due to the defective methodology. Rigorous experimental design following the guidelines of autophagy assays, molecular target identification and in vivo efficacy evaluation is critical for the development of ALP enhancers for PD treatment in future studies.

show abstract

“…Leading to movement control impairment, motor symptoms are considered cardinal in PD. Consequently, they are the primary focus (Li, Dong, Cheng, & Le, 2016;Glickman-Simon, Karp, & Sethi, 2015;Yang, Qiu, Hao, Lv, Jiao, & Teng, 2015;Yang, Hao, Tian, Gong, Zhang, Shi, Zhao, 2015).…”

Section: Resultsmentioning

confidence: 99%

Proceedings of the Iii International Scientific and Practical Conference “Psychological Health of the Person: Life Resource and Life Potential”

2017

View full text Add to dashboard Cite

The Proceedings cover different aspects of mental health research concerned with human life resource and life potential, as well as applied aspects of health psychology.The editorial policy was based on the principles of selection and reviewing of all submitted manuscripts. At the first stage all the manuscripts underwent an initial review by the Editor-in-Chief and the Editorial Board before peer-review in order to assess whether their content complied with the Conference theme. The manuscripts which did not comply with the subject matter of the Conference have been rejected. At the second stage all the manuscripts underwent a double blind review process: each work was reviewed by two experts from the Board of Reviewers; reviewing procedure was anonymous both for the experts and authors.In case of positive review results provided by both experts the contributions were included in the Editor-in-Chief Portfolio. At the third stage manuscripts underwent scientific style as well as language literacy assessment and language editing. This work was carried out by the team of Language Editors. Based on the results of the three stages of reviewing the list of the manuscripts recommended for the publication in the Conference Proceedings has been defined.The problem of assessment, prophylaxis and preserving human psychological health is of utmost importance today. Its relevance is determined, first, by the fact that both a person and his / her development as a healthy and autonomous personality represent a subject of a psychological research. Second, recent global transformations impose special requirements to the person seeking for health preservation, self-development, and self-actualisation. Among these requirements there is readiness to act in new, unpredictable conditions, to make decisions in unstable situations and to bear responsibility for one's decisions. To meet these requirements, a person should be able to see opportunities for self-development and self-fulfillment in the surrounding world, finding new meanings of his / her life activity.Existence of life resource and life potential expands the scope of any person's activities, turning the person's significant life purposes into more achievable ones. Resources are known to subjectively increase the value of a person both in his / her self-perception and in the eyes of others, making the person stronger, more prominent and proactive.Among various human resources health is a fundamental one. At the same time, life potential is not a less important characteristic, since it ensures human capacity to create, develop and use life conditions, factors and circumstances which are beneficial for an organism.Considering human health through the prism of life potential, it is necessary that the value of health within culture of its formation should be the highest, being defined not so much by the need for self-preservation but for self-improvement.The presented Proceedings are the result of both scientific studies in Psychology and fruitful and prospective long-term inte...

show abstract

Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions

Cited by 44 publications

References 214 publications

Neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture

Neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

Proceedings of the Iii International Scientific and Practical Conference “Psychological Health of the Person: Life Resource and Life Potential”

Contact Info

Product

Resources

About