Therapie der malignen Schilddrüsentumoren

Becker, H. D.; Röher, H. D.; Peitsch, W.; Wahl, R. A.; Heinze, H. G.; Benker, G.; Dabag, S.; Reinwein, D.; Seeber, S.

doi:10.1007/978-3-642-69398-4_6

Cited by 3 publications

(4 citation statements)

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“…Chemotherapy is the last resort in therapy for patients with thyroid carcinoma [10]. The number of patients suffering from anaplastic tumors is relatively small and different chemotherapeutic regimens have been used in different, and hardly corn- parable, series [13]. The most common drug used has been doxorubicin (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…The most common drug used has been doxorubicin (Table 3). Of 12 patients with anaplastic thyroid carcinoma, who were treated with cytostatic drugs [13], 4 responded (Table 9). Therefore, doxorubicin was tested in our model, alone and in combination with cyclophosphamide.…”

Section: Discussionmentioning

confidence: 99%

“…Xenotransplantation and passage of undifferentiated thyroid carcinomas without change of the histological type has, however, been described [6] and 26 thyroid carcinomas have been transplanted to nude mice (Table 4). The best Modified from Benker et al [13].…”

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Cytostatic drug therapy in anaplastic thyroid carcinoma

et al. 1986

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Anaplastic thyroid carcinomas are relatively rare and have a poor prognosis. In most cases, radical surgical procedures are impossible. Recently, a combination therapy of surgical resection, percutaneous irradiation, and chemotherapy has been described in the literature. After xenotransplantation in athymic nude mice, anaplastic thyroid carcinomas show the same histological features compared to the donors. By passing the tumor over several generations of nude mice, a constant growth rate has been observed. The model allows testing of therapeutic approaches in thyroid carcinoma tissues under in vivo conditions. In 2 different studies with 2 different anaplastic transplants, a statistically significant growth inhibition could be observed using doxorubicin therapy. In one study, combination therapy was performed. The results show no statistically significant difference in the group treated by doxorubicin alone. Further investigations, under in vivo conditions, will show whether a suitable combination therapy for anaplastic thyroid carcinoma can be developed.In most series, anaplastic thyroid carcinomas make up 5-30% of thyroid malignancies [1]. In central Europe over the last few years, there has been a slight decrease in anaplastic carcinomas and an increase of well-differentiated tumor [2]. In our own material, anaplastic thyroid carcinomas were found Supported by Deutsche Forschungsgemeinschaft, We 1076 1-1/84.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cytostatic drug therapy in anaplastic thyroid carcinoma

et al. 1986

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“…Eine besondere Gefahrenzone stellt zum Beispiel die Kreuzungsstelle des Nerven mit der A. thyroidea inferior dar. Lähmungserscheinungen können auch ohne sichtbare Kontinuitätsdurch-trennungen im Nervenverlauf auftreten (1). Hierin begründet sich zum Beispiel die hohe spontane Rückbildungsrate von bis zu 86% der Fälle einer postoperativ bestehenden Rekurrensparesen (11).…”

Section: Diskussionunclassified

Laterofixation der Stimmlippe statt Tracheotomie bei akuter beidseitiger Stimmlippenparese

Werner

Lippert²

2002

Dtsch med Wochenschr

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Laterofixation via endo-extralaryngeal suture technique improves the airway situation immediately in patients suffering from bilateral vocal cord paralysis due to benign or malignant thyroid surgery. Thus tracheostomy can be avoided. The advantage of the reversibility of this technique becomes evident by the fact that the threads can be removed with recovery of the function of the vocal cords. The limits of this method seem to be achieved when the vocal cord is previously damaged due to e.g. a long-term intubation which results in an increased vulnerability of the vocal cords. Thus they cannot sufficiently resist the suture material.

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7. Radikalitätsprinzipien bei der Operation maligner Schilddrüsentumoren

Wahl

Goretzki

Joseph

et al. 1985

Langenbecks Arch Chiv

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Different concepts are required by different tumors: anaplastic carcinomas rarely are accessible to curative surgery, but tumor reduction gives sense in combined concepts. In follicular carcinomas general ("near"-) total thyroidectomy + radioiodine + hormonal suppressive therapy is recommended, with respect to the high incidence of distant metastases even in low 1 degree Tu-stages. Papillary carcinomas allow a stage related procedure with exceptions from total thyroidectomy: no reintervention for "occult" carcinomas and-in patients under 40 years of age-hemithyroidectomy for intrathyroid tumors without regional metastases. In C-Cell-carcinomas total thyroidectomy has to be accompanied by lymph-node dissections of various extent, depending on familiary or sporadic type and tumor-stage.

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Therapie der malignen Schilddrüsentumoren

Cited by 3 publications

References 71 publications

Cytostatic drug therapy in anaplastic thyroid carcinoma

Cytostatic drug therapy in anaplastic thyroid carcinoma

Laterofixation der Stimmlippe statt Tracheotomie bei akuter beidseitiger Stimmlippenparese

7. Radikalitätsprinzipien bei der Operation maligner Schilddrüsentumoren

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