Therapeutics of Laxative Agents with Special Reference to the Anthraquinones

Godding, Edmund W.

doi:10.1159/000136688

Cited by 24 publications

(19 citation statements)

References 10 publications

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“…Chronic abuse of anthraquinone stimulant laxatives can lead to hepatitis [100] and electrolyte disturbances (hypokalaemia, hypocalcaemia), metabolic acidosis, malabsorption, weight loss, albuminuria, and haematuria [101,102]. Weakness and orthostatic hypotension may be exacerbated in elderly patients when stimulant laxatives are repeatedly used [103].…”

Section: Adverse Reactionsmentioning

confidence: 99%

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Sahu¹,

Giri²,

Singh³

et al. 2013

221

117

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The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, antimicrobial, anti inflammatory, anti-oxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative.

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Section: Adverse Reactionsmentioning

confidence: 99%

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Sahu¹,

Giri²,

Singh³

et al. 2013

221

117

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“…As far as senna is concerned, there are frequent references in the literature to an impression voiced by Illingworth in 1953 that some breast-fed infants whose mothers were taking cascara or senna had soft faeces. It has been repeatedly stressed in the literature that there was often an uncritical acceptance of this assumption as a fact [Burgess, 1972;Godding. 1976].…”

Section: Discussionmentioning

confidence: 99%

Relevance of Rhein Excretion into Breast Milk

Faber¹,

Strenge-Hesse²

1988

Pharmacology

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The excretion of rhein, a laxatively active metabolite of sennosides, was investigated in 100 breast milk samples of 20 post-partum women after intake of a standardized senna laxative (Agiolax), which also contains seeds of Plantago ovata as bulk substances. After daily doses of 5 g of the senna laxative containing 15 mg sennosides for 3 days, the rhein concentration in milk samples from every lactation during 24 h post-dose varied between 0 and 27 ng/ml with values below 10 ng/ml in 94%. Based on median values, 0.007% of the sennoside intake (calculated as rhein) was excreted in breast milk. None of the breast-fed infants had an abnormal stool consistency. Assuming a (theoretical) complete metabolism of sennosides to rhein in the mother, the amount of rhein delivered to the infant (ng/kg b.w.) is by the factor 10^–3 below the rhein intake of the mother.

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“…Também é utilizado na medicina veterinária nos casos de icterícia em cães e vitelas 7,12,13 . É preparado em formas farmacêuticas como infusões, decocções e tinturas, assim como na forma de vinho ou marmelada, dependendo da finalidade 2 .…”

Section: Introductionunclassified

“…. Estas glândulas claras são formadas por espaços esquizóides intercelulares, revestidos de células que secretam um óleo essencial translúcido 7,8,9,10 . H. brasiliense é caracterizado por seu porte herbáceo, variando entre 0,5 e 1,0 m de altura, ramificado desde a base.…”

Section: Introductionunclassified

Avaliação da qualidade de matérias-primas de ruibarbo utilizadas em formulações farmacêuticas

Sousa¹,

Oliveira²,

Cunha³

et al. 2003

Rev. bras. farmacogn.

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Resumo As plantas denominadas de ruibarbo sintetizam antraquinonas e taninos, que são responsáveis pelos efeitos laxante e adstringente, respectivamente. Análises da qualidade de cinco matérias-primas de ruibarbo foram realizadas a fim de detectar adulterações. As reações para antraquinonas e taninos foram positivas. Os constituintes rapônticos foram observados na amostra de Rheum palmatum (2). As medidas de cinzas totais para Rheum palmatum (2) e Ferraria cathartica estão acima do esperado. Conforme resultados, as amostras de Rheum palmatum (2) e Ferraria cathartica devem estar adulteradas. AbstractPlants known as rhubarb synthesize anthraquinones and tannins. Theses compounds have medicinal uses as laxative and astringent, respectivity. The quality of five raw materials was analysed to detect adulterant. Anthraquinones and tannins reactions were positive. Derivatives rhapontocoside were observed in the sample of Rheum palmatum (2). Total ashes were increased to Rheum palmatum (2) and Ferraria cathartica. According to the results, samples of Rheum palmatum (2) and Ferraria cathartica shoulde are adulterated.O ruibarbo é uma droga fitoterápica empregada contra diversos distúrbios, principalmente das funções do estômago e fígado, sendo considerado como excelente tônico e purgante. Também é utilizado na medicina veterinária nos casos de icterícia em cães e vitelas 7,12,13 . É preparado em formas farmacêuticas como infusões, decocções e tinturas, assim como na forma de vinho ou marmelada, dependendo da finalidade 2 . Os constituintes químicos encontrados no ruibarbo responsáveis pelos efeitos terapêuticos são descritos como derivados antracênicos e taninos. As hidroximetilantraquinonas oscilam entre 2 a 5%, podendo atingir até 7,5%. Os taninos formam outro grupo característico do ruibarbo que, por hidrólise,

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Therapeutics of Laxative Agents with Special Reference to the Anthraquinones

Cited by 24 publications

References 10 publications

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Relevance of Rhein Excretion into Breast Milk

Avaliação da qualidade de matérias-primas de ruibarbo utilizadas em formulações farmacêuticas

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Therapeutics of Laxative Agents with Special Reference to the Anthraquinones

Cited by 24 publications

References 10 publications

Therapeutic and Medicinal Uses of &lt;i&gt;Aloe vera&lt;/i&gt;: A Review

Therapeutic and Medicinal Uses of &lt;i&gt;Aloe vera&lt;/i&gt;: A Review

Relevance of Rhein Excretion into Breast Milk

Avaliação da qualidade de matérias-primas de ruibarbo utilizadas em formulações farmacêuticas

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Product

Resources

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Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review