Therapeutics for Inflammatory-Related Diseases Based on Plasmon-Activated Water: A Review

Yang, Chih Ping; Liu, Yu Chuan

doi:10.3390/ijms19061589

Cited by 4 publications

(6 citation statements)

References 100 publications

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“…muciniphila can ameliorate IBD severity. In other words, PAW may have antitumor potential [ 12 , 49 ], and A . muciniphila may help repair intestinal barriers [ 41 , 51 , 52 , 53 ] by promoting the secretion of colonic mucins [ 54 ] and increasing the thickness of the mucus layer [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…Plasmon-activated water (PAW), prepared by using Au nanoparticles (AuNP)-adsorbed ceramics under resonant illumination with a green light-emitting diode, has various molecular properties (e.g., antioxidant and anti-inflammatory) and functions [ 10 , 11 ]. Daily consumption of PAW, which has potential anti-tumor metastatic properties [ 11 ], can mitigate various inflammatory-related diseases [ 12 , 13 ]. However, as far as we know, few studies have focused on the anti-inflammatory properties of PAW on IBD treatment by changing the gut microbiome.…”

Section: Introductionmentioning

confidence: 99%

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Functional Plasmon-Activated Water Increases Akkermansia muciniphila Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease

Chang

Liu

et al. 2022

IJMS

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Inflammatory bowel disease (IBD) is associated with dysbiosis and intestinal barrier dysfunction, as indicated by epithelial hyperpermeability and high levels of mucosal-associated bacteria. Changes in gut microbiota may be correlated with IBD pathogenesis. Additionally, microbe-based treatments could mitigate clinical IBD symptoms. Plasmon-activated water (PAW) is known to have an anti-inflammatory potential. In this work, we studied the association between the anti-inflammatory ability of PAW and intestinal microbes, thereby improving IBD treatment. We examined the PAW-induced changes in the colonic immune activity and microbiota of mice by immunohistochemistry and next generation sequencing, determined whether drinking PAW can mitigate IBD induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) and dysbiosis through mice animal models. The effects of specific probiotic species on mice with TNBS-induced IBD were also investigated. Experimental results indicated that PAW could change the local inflammation in the intestinal microenvironment. Moreover, the abundance of Akkermansia spp. was degraded in the TNBS-treated mice but elevated in the PAW-drinking mice. Daily rectal injection of Akkermansia muciniphila, a potential probiotic species in Akkermansia spp., also improved the health of the mice. Correspondingly, both PAW consumption and increasing the intestinal abundance of Akkermansia muciniphila can mitigate IBD in mice. These findings indicate that increasing the abundance of Akkermansia muciniphila in the gut through PAW consumption or other methods may mitigate IBD in mice with clinically significant IBD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional Plasmon-Activated Water Increases Akkermansia muciniphila Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease

Chang

Liu

et al. 2022

IJMS

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“…Hot electron transfer can promote numerous chemical reactions [ 36 ], including dissociation of hydrogen [ 37 ], activation of oxygen [ 38 ], as well as electrocatalytic hydrogen evolution [ 39 ]. Our group proposed an innovative method to create PAW, which is prepared by treating ROW with resonantly excited AuNPs [ 1 , 40 , 41 ]. Recently, we have demonstrated that PAW is innovatively applicable in various fields [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our group proposed an innovative method to create PAW, which is prepared by treating ROW with resonantly excited AuNPs [ 1 , 40 , 41 ]. Recently, we have demonstrated that PAW is innovatively applicable in various fields [ 40 ]. PAW, with its unique properties of enhancing solute diffusion, as well as its exhibited anti-inflammatory properties, considerably shortens the time required to remove uremic contaminants during hemodialysis therapy [ 2 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Transferring Plasmon Effect on a Biological System: Expression of Biological Polymers in Chronic Rejection and Inflammatory Rat Model

et al. 2021

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The plasmon-activated water (PAW) that reduces hydrogen bonds is made of deionized reverse osmosis water (ROW). However, compared with ROW, PAW has a significantly higher diffusion coefficient and electron transfer rate constant in electrochemical reactions. PAW has a boiling point of97 °C and specific heat of0.94; the energy of PAW is also 1121 J/mol higher than ordinary water. The greater the force of hydrogen bonds between H2O, the larger the volume of the H2O cluster, and the easier it is to lose the original characteristics. The hydrogen bonding force of PAW is weak, so the volume of its cluster is small, and it exists in a state very close to a single H2O. PAW has a high permeability and diffusion rate, which can improve the needs of biological applications and meet the dependence of biological organisms on H2O when performing physiological functions. PAW can successfully remove free radicals, and efficiently reduce lipopolysaccharide (LPS)-induced monocytes to release nitric oxide. PAW can induce expression of the antioxidant gene Nrf2 in human gingival fibroblasts, lower amyloid burden in mice with Alzheimer’s disease, and decrease metastasis in mice grafted with Lewis lung carcinoma cells. Because the transferring plasmon effect may improve the abnormality of physiological activity in a biological system, we aimed to evaluate the influence of PAW on orthotopic allograft transplantation (OAT)-induced vasculopathy in this study. Here, we demonstrated that daily intake of PAW lowered the progression of vasculopathy in OAT-recipient ACI/NKyo rats by inhibiting collagen accumulation, proliferation of smooth muscle cells and fibroblasts, and T lymphocyte infiltration in the vessel wall. The results showed reduced T and B lymphocytes, plasma cells, and macrophage activation in the spleen of the OAT-recipient ACI/NKyo rats that were administered PAW. In contrast to the control group, the OAT-recipient ACI/NKyo rats that were administered PAW exhibited higher mobilization and levels of circulating endothelial progenitor cells associated with vessel repair. We use the transferring plasmon effect to adjust and maintain the biochemical properties of water, and to meet the biochemical demand of organisms. Therefore, this study highlights the therapeutic roles of PAW and provides more biomedical applicability for the transferring plasmon effect.

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“…Our group proposed an innovative method to create PAW, which is prepared by treating ROW with resonantly excited AuNPs 10,37,38 . Recently, we have demonstrated that PAW is innovatively applicable in various elds 39 . PAW with its unique properties of enhancing solute diffusion as well as exhibiting anti-in ammatory properties considerably shortens the time required to remove uremic contaminants during hemodialysis therapy 11,40 .…”

Section: Discussionmentioning

confidence: 99%

Plasmon-Activated Water Decreases Vasculopathy in Orthotopic Allograft Transplantation Rats

Tsai

Lin

Shih

et al. 2020

Preprint

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Patients undergoing orthotopic allograft transplantation (OAT) will certainly suffer from vasculopathy. Although there are many immunosuppressive and immunomodulatory agents that are administered to patients, chronic rejection- induced vasculopathy cannot be entirely managed. Moreover, the implanted graft might become dysfunctional. In the past, we have used deionized reverse osmosis water (ROW) to stream via gold nanoparticles (AuNPs) at room temperature under powerful illumination, in order to prepare plasmon-activated water (PAW) with fewer hydrogen bonds. Compared to ROW, stable PAW can successfully remove free hydroxyl and 2,2-diphenyl-1-picrylhydrazyl radicals, and efficiently reduce lipopolysaccharide (LPS)-induced monocytes to release nitric oxide. Moreover, PAW can considerably induce the expression of the antioxidant gene Nrf2 in human gingival fibroblasts. Moreover, it might lower amyloid burden in mice with Alzheimer's disease. Furthermore, PAW decreased metastasis in mice grafted with Lewis lung carcinoma cells and boosted the overall survival in combination with cisplatin. Because of this possibility that PAW could prevent systemic disease, we aimed to evaluate the influence of PAW on OAT-induced vasculopathy. Here, we demonstrated that daily intake of PAW lowered the progression of vasculopathy in OAT-recipient ACI/NKyo rats by inhibiting collagen accumulation, proliferation of smooth muscle cells and fibroblasts, and T lymphocyte infiltration in the vessel wall. Moreover, the results showed reduced T and B lymphocytes, plasma cells, and macrophage activation in the spleen of the OAT-recipient ACI/NKyo rats that were administered PAW. Finally, in contrast to the control group, the OAT-recipient ACI/NKyo rats that were administered PAW exhibited higher mobilization and levels of circulating endothelial progenitor cells associated with vessel repair. Therefore, this study highlights the therapeutic roles of PAW in vasculopathy.

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Therapeutics for Inflammatory-Related Diseases Based on Plasmon-Activated Water: A Review

Cited by 4 publications

References 100 publications

Functional Plasmon-Activated Water Increases Akkermansia muciniphila Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease

Functional Plasmon-Activated Water Increases Akkermansia muciniphila Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease

Transferring Plasmon Effect on a Biological System: Expression of Biological Polymers in Chronic Rejection and Inflammatory Rat Model

Plasmon-Activated Water Decreases Vasculopathy in Orthotopic Allograft Transplantation Rats

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