Therapeutic strategy for efficient reduction of serum uric acid levels with allopurinol versus benzbromarone in hyperuricemic patients with essential hypertension — A randomized crossover study (terao study)

Kojima, Sunao; Kojima, Sachi; Hifumi, Atsuko; Soejima, Hirofumi; Ogawa, Hisao

doi:10.1016/j.ijcard.2016.09.073

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…One effective treatment for patients with hyperuricemia is the use of XO inhibitors, which directly block the oxidation of hypoxanthine and xanthine to produce uric acid. Several XO inhibitors have been developed, such as clinically approved allopurinol and febuxostat ( Kojima et al, 2016 ; Packer, 2020 ). However, side effects of these drugs have been observed during clinical applications, so it is important to find new XO inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Quantitative structure–activity relationship study of amide derivatives as xanthine oxidase inhibitors using machine learning

et al. 2023

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The target of the study is to predict the inhibitory effect of amide derivatives on xanthine oxidase (XO) by building several models, which are based on the theory of the quantitative structure–activity relationship (QSAR). The heuristic method (HM) was used to linearly select descriptors and build a linear model. XGBoost was used to non-linearly select descriptors, and radial basis kernel function support vector regression (RBF SVR), polynomial kernel function SVR (poly SVR), linear kernel function SVR (linear SVR), mix-kernel function SVR (MIX SVR), and random forest (RF) were adopted to establish non-linear models, in which the MIX-SVR method gives the best result. The kernel function of MIX SVR has strong abilities of learning and generalization of established models simultaneously, which is because it is a combination of the linear kernel function, the radial basis kernel function, and the polynomial kernel function. In order to test the robustness of the models, leave-one-out cross validation (LOOCV) was adopted. In a training set, R2 = 0.97 and RMSE = 0.01; in a test set, R2 = 0.95, RMSE = 0.01, and Rcv2 = 0.96. This result is in line with the experimental expectations, which indicate that the MIX-SVR modeling approach has good applications in the study of amide derivatives.

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Section: Introductionmentioning

confidence: 99%

Quantitative structure–activity relationship study of amide derivatives as xanthine oxidase inhibitors using machine learning

et al. 2023

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“…Therefore, these renal urate transport-related proteins constitute important targets for the effective agents to prevent and treat hyperuricemia and gout. Various uricosuric substances known to reduce hyperuricemia, such as probenecid, fenylbutazone, sul npyrazone, NSAIDs, and diuretic drugs, effectively inhibit URAT1.Benzbromarone (a uricosuricagent used clinically) is the most potent, completely inhibiting the urate uptake via URAT1 [13,14].…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperuricemic effect of Polydatin in model mice: promoting uric acid excretion and inhibiting XOD

Jiang

et al. 2021

Preprint

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Objective The aim of this study was to understand the role of anti-hyperuricemic mechanism and nephro-protective effects of polydatin. Methods The oxonate-induced hyperuricemia mice model was established and uric acids in serum were observed. Kidney tissues were used to detect gene contents of URAT1, OAT1 and OAT3 by real-time-PCR. and to detect pathological features .The activity of XOD in liver tissues of mice was detected . Results Polydatin significantly reduced serum urate levels in hyperuricemic mice. Polydatin significantly inhibited increasing tendency of the mRNA and the protein levels of OAT1 and OAT3 ,and decreasing tendency of the mRNA and the protein level of URAT1 in hyperuricemic mice. Polydatin significantly inhibited the level of XOD in liver tissues of mice in a concentration-dependent manner in hyperuricemic mice. Polydatin showed a protective effect on the pathological injury of kidney in hyperuricemic mice. Conclusion The anti-hyperuricemic effect of polydatin was related to the down-regulation of renal URAT1, up-regulated renal OAT1 and OAT3 and inhibition XOD in the hyperuricemic mice.

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Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system

Shi

Lin

Wang

et al. 2021

Drug Deliv. and Transl. Res.

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Therapeutic strategy for efficient reduction of serum uric acid levels with allopurinol versus benzbromarone in hyperuricemic patients with essential hypertension — A randomized crossover study (terao study)

Cited by 5 publications

References 9 publications

Quantitative structure–activity relationship study of amide derivatives as xanthine oxidase inhibitors using machine learning

Quantitative structure–activity relationship study of amide derivatives as xanthine oxidase inhibitors using machine learning

Anti-hyperuricemic effect of Polydatin in model mice: promoting uric acid excretion and inhibiting XOD

Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system

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