Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system

Photostabilization of ketoprofen by inclusion in glycyrrhizin micelles and gel nanoparticles

“…At pH value >6 GA micelles become unstable due to Coulomb repulsion; however, recent studies show that the supramolecular associates of some drugs with GA exists even at pH 6–7.4. 55–57…”

“…The ability of GA to form self-associates in aqueous solution (micelles and gels) has been demonstrated in numerous studies. 42,43,55,56 Gel-permeation chromatography shows that the mass of the micelles is around 60-70 kDa, so the micelles consist of 80-100 GA molecules. 43 On the other hand, numerical studies using transmission electron microscopy or dynamic light scattering show the presence of spherical nanoparticles of around 30-200 nm.…”

“…43 On the other hand, numerical studies using transmission electron microscopy or dynamic light scattering show the presence of spherical nanoparticles of around 30-200 nm. 55,56 We assume that such discrepancy is due to the simultaneous existence of gels and micelles in GA solution. This phenomenon can be easily observed using NMR techniques, due to the high sensitivity of the NMR line width and nuclear relaxation time to the mobility of molecules.…”

“…At pH value 46 GA micelles become unstable due to Coulomb repulsion; however, recent studies show that the supramolecular associates of some drugs with GA exists even at pH 6-7.4. [55][56][57] First, in this study, we attempted to incorporate KP molecules into GA micelles and gel nanoparticles in acidic (pH o 4) solution using NMR spectroscopy to monitor KP solubilization. Inclusion of KP in the GA micelles and gel nanoparticles results in the broadening of its NMR lines (Fig.…”

Katsuwonus pelamis Peptide and its Complexes Protect Zebrafish and Mice From Hyperuricemia Through Promoting Kidney Excretion of Uric Acid and Inhibiting Liver Xanthine Oxidase Activity

“…Nowadays, a growing number of natural products and their extracts have been demonstrated effective in the treatment of hyperuricemia ( Zhang et al, 2019 ; Cicero et al, 2021b ; Shi et al, 2022 ), which may reduce serum UA level and the occurrence of adverse reaction and need further research ( Zhu et al, 2021 ). Katsuwonus pelamis , also known as bullet mackerel, is a kind of tuna with the largest amount of fish trawling in China ( Yang et al, 2016 ; Ma et al, 2017 ; Weng et al, 2019 ).…”