Photostabilization of ketoprofen by inclusion in glycyrrhizin micelles and gel nanoparticles

Abstract

Ketoprofen (KP) is known to be the most photosensitive among the nonsteroidal anti-inflammatory drugs and may induce phototoxic and photoallergic reactions. Phototoxic side effects of KP are associated with the...

Physicochemical Approaches to the Study of the Antioxidant Activity of Glycyrrhizin

“…The formation of these species was proved by chemical nuclear polarization in addition to other methods [ 72 , 73 ]. Selyutina et al [ 74 ] attempted to use glycyrrhizin to increase the photostability of KP. To study the photolysis of ketoprofen in micelles and gel nanoparticles of GA, they also used CIDNP and NMR.…”

“…The antioxidant activity of GA was also studied by CIDNP technique [ 74 , 95 ], which is one of the most informative experimental methods for studying free radical reactions in complex chemical and biochemical processes [ 96 – 98 ]. The authors traced the effect of GA on the behavior of paramagnetic species formed during UV irradiation of xenobiotics, including drug molecules (naproxen and ketoprofen), and found that the concentration of free radicals in solutions decreased in the presence of GA [ 74 , 95 ]. In addition, it was reliably established by CIDNP method that the GA molecule captures the solvated electron generated by UV irradiation of naproxen and ketoprofen.…”