Therapeutic strategies in promoting peripheral nerve regeneration

Horowitz, Steven H.

doi:10.1002/mus.880120410

Cited by 30 publications

(3 citation statements)

References 57 publications

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“…43 Results of clinical studies using this agent are mixed. 58 Glia-Derived Protease Inhibitor. Glia-derived protease inhibitor, a polypeptide purified from glial-conditioned medium, promotes neurite outgrowth in neuroblastoma cells; the mechanism of action is unknown.…”

Section: Metabolic and Other Factors Promoting Nerve Regenerationmentioning

confidence: 99%

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Enhancement of peripheral nerve regeneration

Seckel

1990

Muscle and Nerve

190

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Numerous factors external to the nerve cell can support and enhance nerve regeneration after injury. The definition of these factors and the elucidation of their mechanisms of action are the central goals of much contemporary neurobiologic research. This research will hopefully lead to the discovery of factors that will prove to be therapeutically beneficial for patients with either peripheral nervous system (PNS) injury or central nervous system (CNS) injury. This article reviews the biology of the regeneration response of the nerve to injury and discusses many of the factors that enhance nerve growth. Finally, the nerve guide or nerve regeneration chamber model for the evaluation of putative nerve regeneration enhancing agents in vivo is also discussed.

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Section: Metabolic and Other Factors Promoting Nerve Regenerationmentioning

confidence: 99%

“…"~ Any potential therapeutic value is, however, limited by its hepatotoxicity. 58 Muscle-Basement Membrane. Several studies have shown that rat peripheral nerve regenerates into muscle-basement membrane of degenerated rat muscle a l l~g r a f t s .~~~~~~'~~ Electrical Stimulation.…”

Section: Metabolic and Other Factors Promoting Nerve Regenerationmentioning

confidence: 99%

Enhancement of peripheral nerve regeneration

Seckel

1990

Muscle and Nerve

190

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“…The experimental use of promoting factors in association with nerve conduits has been widely studied [16,27]. Among these substances there are nerve growth factors [6], insulin-like growth factors [14] and laminin [18] when neurotrophic factors are introduced into the lumen of the conduit there is an early peak in the resulting activity followed by a progressive decrease.…”

Section: Discussionmentioning

confidence: 99%

Guided regeneration with resorbable conduits in experimental peripheral nerve injuries

Aldini

Fini

Rocca

et al. 2000

International Orthopaedics

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Guided tissue regeneration is a new approach in the reconstructive surgery of peripheral nerves. Artificial conduits can be constructed from biodegradable polymers. Lactic/caproic acid copolymers and polyphospazenes are biocompatible materials with a slow resorption rate. Conduits made from either poly-[l-lactide-co-6-caprolatone] or poly-[bis-(ethylalanate)-phosphazene] were assessed for use as guides for nerve regeneration in experimental animals. Under general anesthesia and by using a microsurgery technique both sciatic nerves were exposed in 2 groups of 9 Wistar rats. On the right side, a 10 mm segment of the nerve was removed, and the defect was then repaired using a conduit. On the left side, the same defect was bridged using as an autograft the nerve segment, which had been removed from the right sciatic nerve. Histological and electron microscopy investigations were performed after 30, 90 and 180 days and showed the gradual degradation of both types of conduits without any evidence of local toxicity. The regeneration of the nerve fibers in the lumen was not significantly different from that shown by the autologous grafts. Likewise, no differences were found at 180 days in the functional recovery of the nerve (evoked muscle action potential). Both conduits were found to be effective for guided nerve regeneration. Poly-[l-lactide-co-6-caprolactone] tubes were easier to insert, while polyphosphazene conduits allowed the use of neurite-promoting factors.Résumé La régénération tissulaire guidée est une nouvelle perspective dans la reconstruction des nerfs péri-phériques. Des conduits artificiels peuvent être obtenus avec des polymères biodégradables. Nous avons évalué dans un modèle expérimental deux types de polymères le poly-[1-lactide-co-6-caprolactone] et le poly-[bis-(etilalanate)-phosphazene]. Cette expérimentation a été, conduite sous anesthésie générale au niveau du nerf sciatique de 9 rats Wistar, un segment de 10 mm de nerf a été réséqué et du côté droit la reconstruction a été faite en utilisant une polymère du côté gauche, la réparation a été faite avec une autogreffe avec le segment réséqué du cô-té opposé. Une étude histologique et par microscopie électronique a été faite à 30, 90 et 180 jours. Il n'y a pas eu de toxicité locale des conduits en polymère. La régé-nération des fibres nerveuses dans les deux types de conduits ne fut pas différente de celle observée avec les autogreffes. Les deux types de conduits peuvent être considérés comme efficaces pour guider la régénération nerveuse. Le tube en polycaprolactone est plus maniable alors que celui en polyphosphazene peut contenir des facteurs favorisant la croissance axonale.

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Enhancement of motor nerve regeneration by nerve growth factor

Chen

1992

Microsurgery

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The sciatic nerves of adult Wistar rats were severed bilaterally. Each nerve was sutured into a silicone tube used as a conduit, leaving a 5 mm gap in length between the nerve ends. Nerve growth factor in a saline solution vehicle was injected into the silicone chamber on the right side and normal saline solution (control) on the left. Six weeks after surgery, electrophysiological studies were performed. The motor nerve conduction velocities (MNCV) were significantly increased in the NGF-treated nerves. In one rat, the MNCV on the NGF-treated side was 66.6 m/s, in the range of normal nerves. There was no significant difference between the two sides in the amplitudes of evoked muscle action potentials. There are apparently no reports on the effect of NGF on motor neuron regeneration in vitro. In this study, NGF was found to enhance motor nerve regeneration.

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Therapeutic strategies in promoting peripheral nerve regeneration

Cited by 30 publications

References 57 publications

Enhancement of peripheral nerve regeneration

Enhancement of peripheral nerve regeneration

Guided regeneration with resorbable conduits in experimental peripheral nerve injuries

Enhancement of motor nerve regeneration by nerve growth factor

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