Enhancement of motor nerve regeneration by nerve growth factor

He, Chongliang; Chen, Zhongwei; Chen, Zhengrong

doi:10.1002/micr.1920130310

Cited by 74 publications

(33 citation statements)

References 6 publications

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“…15À18,22,30,31 Chen et al 15 reported improved facial nerve regeneration through silicone tubes with the use of NGF. Ç e et al 30 found that NGF enhances motor nerve conduction velocity in a rat sciatic nerve model. According to Chen and Wang, 31 NGF administration ensures better electrophysiological and histologic findings in a crushed sciatic nerve model in rats.…”

Section: Discussionmentioning

confidence: 98%

Beneficial effect of nerve growth factor‐7S on peripheral nerve regeneration through inside‐out vein grafts: An experimental study

et al. 2004

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This study investigated the effect of local administration of nerve growth factor-7S (NGF-7S) on the axonal regrowth of mixed peripheral nerves through inside-out vein grafts. Sixty male Wistar rats were randomized into two groups (n = 30). A defect 12 mm long in the right sciatic nerve was created and repaired with an inside-out vein graft from the right jugular vein. NGF-7S (group A) or phosphate-buffered saline (group B; control) was locally administered daily during the first 3 weeks. Walking-track analysis and electrophysiological and histological-morphometric studies were carried out 4, 6, 8, 10, and 12 weeks postoperatively (subgroups a, b, c, d, and e, respectively, n = 6 each). Data analysis showed that 1) the recovery of motor function, as measured by walk pattern analysis and evoked muscle action potential, and 2) the orientation, number, myelin thickness, and diameter of myelinated fibers were better in the NGF-7S than in the control group. These findings present strong evidence of the beneficial effect of NGF-7S on peripheral nerve regeneration through inside-out vein grafts.

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Section: Discussionmentioning

confidence: 98%

Beneficial effect of nerve growth factor‐7S on peripheral nerve regeneration through inside‐out vein grafts: An experimental study

et al. 2004

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“…[37][38][39] A few recent reports showing that NGF enhances regeneration in motor nerve as well as sensory nerve may possibly be due to its combination with fibronectin or to other combined effects on the motor nerve. 40, 41 Ang et al 42 found that in vitro, NGF does promote neurite growth of cultured motoneurones through interactions with astrocytes, but that in the absence of astrocytes, the increase in neurite growth is not significant. One possible reason why NGF might promote motor nerve regeneration is the action of exogenous NGF on upregulated p75NGFR in Schwann cells.…”

Section: Neurotrophic Factors and Peripheral Nerve Regenerationmentioning

confidence: 96%

Schwann cells, neurotrophic factors, and peripheral nerve regeneration

1998

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The peripheral nervous system retains a considerable capacity for regeneration. However, functional recovery rarely returns to the preinjury level no matter how accurate the nerve repair is, and the more proximal the injury the worse the recovery. Among a variety of approaches being used to enhance peripheral nerve regeneration are the manipulation of Schwann cells and the use of neurotrophic factors. Such factors include, first, nerve growth factor (NGF) and the other recently identified members of the neurotrophin family, namely, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4/5 (NT-4/5); second, the neurokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF); and third, the transforming growth factors (TGFs)-beta and their distant relative, glial cell line-derived neurotrophic factor (GDNF). In this review article we focus on the roles in peripheral nerve regeneration of Schwann cells and of the neurotrophin family, CNTF and GDNF, and the relationship between these. Finally, we discuss what remains to be understood about the possible clinical use of neurotrophic factors.

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“…Chen et al [5] reported improved facial nerve regeneration through silicone tubes with the use of NGF. He et al [10] found that NGF enhances motor nerve conduction velocity in a rat sciatic nerve model. According to Chen and Wang [6] NGF administration ensures better electrophysiological and histological findings on a crushed sciatic nerve model in rats.…”

Section: Discussionmentioning

confidence: 98%

“…As a result it has been believed that NGF has little or no effect on motoneuronal regeneration [25]. Nevertheless, recent experimental studies support the beneficial effect of NGF on motoneuronal regrowth [5,6,10,17,19,20,22].…”

Section: Introductionmentioning

confidence: 97%

Microsurgical repair of nerve lesions with nerve grafts: the effect of nerve growth factor 7S

Gravvanis

Lykoudis

Tagaris

et al. 2002

European Journal of Plastic Surgery

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This study investigated the effect of local administration of nerve growth factor 7S (NGF-7S) on the axonal regrowth of mixed peripheral nerves through nerve grafts. Sixty male Wistar rats were randomized into two groups (n=30). A defect 12 mm long in the right sciatic nerve was created and repaired with a nerve autograft. NGF-7S (group A) or normal saline (group B-control) was locally administered daily during the first 3 weeks. For this purpose a subcutaneously implanted reservoir connected to a silicone tube was used. Electrophysiological and histological-morphometric studies were carried out 4, 6, 8, 10 and 12 weeks postoperatively (subgroups a, b, c, d, and e, respectively, n=6 each). Data analysis showed that: (a) the evoked muscle action potential and (b) the orientation, number, myelin thickness, and diameter of myelinated fibers were better in the NGF-7S than in the control group. These findings present strong evidence of the beneficial effect of NGF-7S on peripheral nerve regeneration through nerve grafts.

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Enhancement of motor nerve regeneration by nerve growth factor

Cited by 74 publications

References 6 publications

Beneficial effect of nerve growth factor‐7S on peripheral nerve regeneration through inside‐out vein grafts: An experimental study

Beneficial effect of nerve growth factor‐7S on peripheral nerve regeneration through inside‐out vein grafts: An experimental study

Schwann cells, neurotrophic factors, and peripheral nerve regeneration

Microsurgical repair of nerve lesions with nerve grafts: the effect of nerve growth factor 7S

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