Therapeutic spectrum of piperine for clinical practice: a scoping review

Yadav, Suraj Singh; Singh, Manish Kumar; Hussain, Sartaj; Dwivedi, Pradeep; Khattri, Sanjay; Singh, Kuldeep

doi:10.1080/10408398.2021.2024792

Cited by 18 publications

(8 citation statements)

References 185 publications

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“…Thus, the results observed for the combination between piperine, and the chemotherapy drugs 5-FU and GEM corroborate the data already reported in the literature, which show significant effects of piperine in increasing the bioavailability of other compounds, such as antitubercular compounds [ 103 ], anti-inflammatory compounds [ 104 ], antibiotics, and even chemotherapeutics [ 105 ]. These reports demonstrate that different systems combined with piperine can have a higher impact on the bioavailability of co-administered drugs by diverse mechanisms, including inhibiting efflux transport, inhibiting intestinal and hepatic metabolism, and modulation of activity and expression of metabolic response enzymes [ 106 ].…”

Section: Resultsmentioning

confidence: 99%

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

et al. 2023

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Gastric cancer is one of the most frequent types of neoplasms worldwide, usually presenting as aggressive and difficult-to-manage tumors. The search for new structures with anticancer potential encompasses a vast research field in which natural products arise as promising alternatives. In this scenario, piperine, an alkaloid of the Piper species, has received attention due to its biological activity, including anticancer attributes. The present work proposes three heating-independent, reliable, low-cost, and selective methods for obtaining piperine from Piper nigrum L. (Black pepper). Electronic (SEM) and optical microscopies, X-ray diffraction, nuclear magnetic resonance spectroscopies (13C and 1H NMR), and optical spectroscopies (UV–Vis, photoluminescence, and FTIR) confirm the obtention of piperine crystals. The MTT assay reveals that the piperine samples exhibit good cytotoxic activity against primary and metastasis models of gastric cancer cell lines from the Brazilian Amazon. The samples showed selective cytotoxicity on the evaluated models, revealing higher effectiveness in cells bearing a higher degree of aggressiveness. Moreover, the investigated piperine crystals demonstrated the ability to act as a good cytotoxicity enhancer when combined with traditional chemotherapeutics (5-FU and GEM), allowing the drugs to achieve the same cytotoxic effect in cells employing lower concentrations. These results establish piperine as a promising molecule for therapy investigations in aggressive gastric cancer, both in its isolated form or as a bioenhancer.

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Section: Resultsmentioning

confidence: 99%

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

et al. 2023

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“…Pepper is a traditional Chinese herbal medicine used for arthritis, bronchitis, gastritis, diarrhea, snake bite, menstrual pain, fever, and bacterial infections [13], these are also recorded in the traditional Chinese medicine classic Tang Ben Cao (pinyin in China) and Ben Cao Gang Mu (pinyin in China). Its functions may be related to the anti-in ammatory and antioxidant effects of its main component, piperine (1peperoylpiperidine).…”

Section: Discussionmentioning

confidence: 99%

“…Piperine is the key alkaloid components of black pepper, a traditional Chinese herbal medicine owing to its antioxidant, anti-microbial, and gastro-protective properties [10]. Piperine contains a wide range of biological properties, including antioxidant [11], anti-microbial [12], anti-in ammatory [13,14], anti-cancer [15], and anti-depressant [16], activities. Piperine has been found to have anti-in ammatory properties in numerous in vitro and in vivo experiments.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the JAK2/STAT3 Signaling Pathway by Piperine Confers Neuroprotection in Rats with Ischemic Stroke

Zou

Zhang

Zhao

et al. 2023

Preprint

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Pepper is a traditional Chinese herbal medicine used for different inflammatory, fever, and bacterial infections. Our previous research shown that the principal pepper active component, piperine, reduces cerebral ischemia-reperfusion (I/R) damage, but the underlying mechanism was not completely understood. In this study, SH-SY5Y cells and Sprague–Dawley rats were pretreated with piperine, AG490, or vehicle. Oxygen–glucose deprivation of SH-SY5Y cells and a rat middle cerebral artery occlusion model were used to mimic cerebral I/R injury. In vitro results from CCK-8 and LDH assays showed that piperine and AG490 mitigated I/R injury induced by OGD and WB showed that piperine lowered the levels of p-JAK2 and p-STAT3. The infarction volume and neuronal apoptosis were reduced by piperine and AG490 in vivo, as demonstrated by TTC, HE, and TUNEL staining. The mNSS, beam-walking test, and MST test indicated that piperine and AG490 promoted recovery of neurological function after I/R injury in rats. These in vivo and in vitro findings demonstrate that the neuroprotective action of piperine on brain I/R injury is mediated by the JAK2/STAT3 signal pathway. It offers a viable therapeutic target for cerebral I/R injury and piperine could be turned into a potential JAK2-specific inhibitor.

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“…Piperine is a pyridine alkaloid isolated from Piper longum L. or Piper nigrum L. ( Yadav et al, 2021 ). Studies have found that piperine shows potential anti-proliferative effects on CD44 + /CD133 + cancer stem cells isolated from HepG2 cells.…”

Section: Therapeutic Effect Of Bioactive Substances On Liver Cancermentioning

confidence: 99%

The pathogenesis of liver cancer and the therapeutic potential of bioactive substances

Gao

Jiang²,

Wang³

et al. 2022

Front. Pharmacol.

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Liver cancer is the third most common cause of cancer-related deaths in the world and has become an urgent problem for global public health. Bioactive substances are widely used for the treatment of liver cancer due to their widespread availability and reduced side effects. This review summarizes the main pathogenic factors involved in the development of liver cancer, including metabolic fatty liver disease, viral infection, and alcoholic cirrhosis, and focuses on the mechanism of action of bioactive components such as polysaccharides, alkaloids, phenols, peptides, and active bacteria/fungi. In addition, we also summarize transformation methods, combined therapy and modification of bioactive substances to improve the treatment efficiency against liver cancer, highlighting new ideas in this field.

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Therapeutic spectrum of piperine for clinical practice: a scoping review

Cited by 18 publications

References 185 publications

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

Inhibition of the JAK2/STAT3 Signaling Pathway by Piperine Confers Neuroprotection in Rats with Ischemic Stroke

The pathogenesis of liver cancer and the therapeutic potential of bioactive substances

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