The pathogenesis of liver cancer and the therapeutic potential of bioactive substances

Gao, Song; Jiang, Xingyue; Wang, Liang; Jiang, Shanshan; Luo, Hanyuan; Chen, Yan; Peng, Cheng Yuan

doi:10.3389/fphar.2022.1029601

Cited by 8 publications

(5 citation statements)

References 171 publications

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“…Polysaccharides are biologically active macromolecules composed of 10 or more monomers linked by glycosidic bonds. Extensive research has highlighted the therapeutic and ameliorative effects of natural polysaccharides on liver cancer, sourced from plants, animals, marine organisms, and fungi [ 7 ]. For instance, polysaccharides purified from Panax ginseng (PHP-1) and active polysaccharides from Ganoderma lucidum (GLPS) function as tumor immunotherapy modulators.…”

Section: Nps With Therapeutic Activity For Liver Cancermentioning

confidence: 99%

“…Nutrients 2024, 16, 1642 2 of 36 Natural products (NPs) exhibit diverse biological activities, including anti-inflammatory and antioxidant properties, rendering them promising sources for developing novel therapies for liver cancer [6,7]. Extensive in vitro and in vivo studies have unveiled the anti-tumor potential of NPs against liver cancer.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Guo,

Yan,

Duan

et al. 2024

Nutrients

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Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting a growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, and minimal side effects. This paper begins by reviewing existing treatment methods and drugs for liver cancer. It then summarizes the therapeutic effects of NPs sourced from various origins on liver cancer. Finally, we analyze the potential mechanisms of NPs in treating liver cancer, including inhibition of angiogenesis, migration, and invasion; regulation of the cell cycle; induction of apoptosis, autophagy, pyroptosis, and ferroptosis; influence on tumor metabolism; immune regulation; regulation of intestinal function; and regulation of key signaling pathways. This systematic review aims to provide a comprehensive overview of NPs research in liver cancer treatment, offering a foundation for further development and application in pharmaceuticals and functional foods.

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Section: Nps With Therapeutic Activity For Liver Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Guo,

Yan,

Duan

et al. 2024

Nutrients

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“…The main risk factors for the development of liver cancer are long-term infection with the hepatitis B virus, hepatitis C virus, hepatitis D virus, nonalcoholic steatohepatitis, alcoholic cirrhosis, autoimmune hepatitis, type 2 diabetes, obesity, and consumption of food contaminated with alpha toxin B1. Gender, geographic region, and age may be associated with the occurrence of liver cancer (Gao et al, 2022).…”

Section: Cancer Cell Growthmentioning

confidence: 99%

Quantum Stem Cell Therapy for Recovery of Liver Disease

Susanti Vinski,

Schroeter,

Hardjo

et al. 2024

JWS

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Chronic liver diseases pose a significant global health challenge, necessitating the development of novel therapeutic strategies for liver regeneration and functional recovery. Mesenchymal stem cells (MSCs) derived from umbilical cord blood have emerged as promising candidates for liver regeneration due to their multipotent differentiation capacity, immunomodulatory properties, and paracrine effects. This study aims to investigate the efficacy, safety, and underlying mechanisms of stem cell therapy in the recovery and regeneration of liver tissue in patients with liver disease. The research method used is a case study where Mesenchymal Stem Cell therapy offers the potential to modify the natural recovery of Liver function using stem cell-based technology. Case studies were carried out on several Vinski Regenerative Center clinic patients. This review explores the therapeutic potential of umbilical cord blood-derived MSCs in promoting the recovery of liver function in preclinical and clinical settings. We discuss the mechanisms by which MSCs facilitate liver regeneration, including their ability to differentiate into hepatocyte-like cells, modulate immune responses, and secrete trophic factors that promote tissue repair. Preclinical studies demonstrate the efficacy of umbilical cord blood-derived MSCs in ameliorating liver injury, reducing fibrosis, and improving overall liver function. Challenges such as optimal dosing, timing of administration, and long-term monitoring remain to be addressed. Nevertheless, MSCs from umbilical cord blood represent a promising therapeutic approach for liver regeneration and hold great potential for improving outcomes in patients with liver disease.

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“…Bioactive peptides are remarkable biomolecules with a wide spectrum of pharmacological functions, including anti-oxidant, antifungal, hypotensive, hypoglycemic, keratolytic, and sedative activities, which are encrypted in their sequences and released during digestion [7][8][9]. It has been reported that bioactive peptides have positive effects against alcohol induced liver damage [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Walnut (Juglans regia L.) Oligopeptides Alleviate Alcohol-Induced Acute Liver Injury through the Inhibition of Inflammation and Oxidative Stress in Rats

et al. 2023

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The study was aimed at investigating the effects of walnut oligopeptides (WOPs) on alcohol-induced acute liver injury and its underlying mechanisms. Male Sprague Dawley (SD) rats were randomly assigned to six groups: normal control, alcohol control, whey protein (440 mg/kg.bw), and three WOPs (220 mg/kg.bw, 440 mg/kg.bw, 880 mg/kg.bw) groups. After 30 days of gavage, ethanol with a volume fraction of 50%, administered at a dose of 7 g/kg.bw., caused acute liver injury. A righting reflex experiment and a blood ethanol concentration evaluation were then performed. Serum biochemical parameters, inflammatory cytokines, liver alcohol metabolism enzymes, oxidative stress biomarkers, liver nuclear factor-κB (NF-κB p65), and cytochrome P4502E1 expression were determined. The results revealed that the intervention of 440 mg/kg and 880 mg/kg WOPs could alleviate the degree of intoxication, decrease blood ethanol concentration, alleviate alcohol-induced hepatic steatosis, enhance the activity of hepatic ethanol metabolizing enzymes and antioxidant capacity, reduce lipid oxidation products and pro-inflammatory factor contents, and inhibit the expression of NF-κBp65 in the livers of rats. The outcomes of the study suggest that WOPs have beneficial effects on liver damage caused by acute ethanol binge drinking, with the high-dose WOPs (880 mg/kg.bw) exerting the most pronounced hepatoprotective effect.

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The pathogenesis of liver cancer and the therapeutic potential of bioactive substances

Cited by 8 publications

References 171 publications

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Quantum Stem Cell Therapy for Recovery of Liver Disease

Walnut (Juglans regia L.) Oligopeptides Alleviate Alcohol-Induced Acute Liver Injury through the Inhibition of Inflammation and Oxidative Stress in Rats

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