Therapeutic role ofCuminum cyminum on ethanol and thermally oxidized sunflower oil induced toxicity

Abstract

Ethanol is one of the most widely used and abused drugs, increasing lipid levels in humans and experimental animals. Heating of oil rich in polyunsaturated fatty acids (PUFA) produces various lipid peroxidative end products that can aggravate the pathological changes produced by ethanol. In the present communication, the effect of Cuminum cyminum was investigated on alcohol and thermally oxidized oil induced hyperlipidaemia. The results showed increased activity of aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) and increased levels of cholesterol, triglycerides and phospholipids in the plasma of rats given alcohol, thermally oxidized oil and alcohol+thermally oxidized oil when compared with the normal control group. The levels of tissue (liver and kidney) cholesterol and triglycerides were increased significantly in rats groups given alcohol, thermally oxidized oil and alcohol+thermally oxidized oil when compared with the normal control rats. The levels were decreased when cumin was given along with alcohol and thermally oxidized oil. The level of phospholipids decreased significantly in the liver and kidney of groups given alcohol, thermally oxidized oil and alcohol+thermally oridized oil when compared with the normal control rats. The level increased when cumin was administered along with alcohol and thermally oxidized oil. The activity of phospholipase A and C increased significantly in the liver of groups given alcohol, thermally oxidized oil and alcohol+thermally oxidized oil when compared with the normal control rats, whereas the activity was decreased with the cumin treatment. The results obtained indicate that cumin can decrease the lipid levels in alcohol and thermally oxidized oil induced hepatotoxicity.

Pretreatment of albino rats with aqueous leaf extract of <i>Ziziphus mauritiana</i> protects against alcohol-induced liver damage

“…Pretreatment with 400 mg/kg bw aqueous extract of Ziziphus mauritiana leaf prevented decrease in body weight gain similar to the group pretreated with silymarin. Other researchers earlier reported significantly decreased body weight gain due to alcohol compared to control rats 20,21 . The levels of total antioxidant status and reduced glutathione were found to significantly decrease in rats that ingested alcohol only compared to normal rats.…”

Cuminum cyminum and Carum carvi: An update

“…Monoterpenes like anethofuran, carvone, and limonene occurring in cumin and caraway oil have specifically been highlighted for anticarcinogenic action. [4098102–105]…”

Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats

“…The plant is indigenous to Turkistan or northern Egypt, but is today widely cultivated in Pakistan, India, Arabia, UAE, Israel, Iran, Iraq, Yugoslavia, Syria, Bulgaria, Malta, Sudan, Cyprus, China and Java. [13] Several studies on anti-diabetic,[14] antioxidant,[15] anti-bacterial,[16] anti-fungal,[17] bronchodilatory,[18] hepatoprotective and renoprotective,[19] chemopreventive,[20] anti-epileptic,[21] galactagogue,[22] Hypolipidemic,[23] male anti-fertility,[24] memory-enhancing and anti-stress[25] effect of C. cyminum seed extracts have been reported in literature. The antidiarrhoeal effect of C. cyminum is mentioned in different system of traditional medicine i.e.…”