Therapeutic Role of Mango Peels in Management of Dyslipidemia and Oxidative Stress in Obese Females

Abstract

Obesity is a chronic metabolic and noncommunicable disease that affects 50% of world population. Reactive oxygen species and oxidative stress are interconnected with the obesity and several metabolic disorders, gaining the attention of scientific community to combat this problem naturally. Among various fruits, mango as a yellow fruit is rich in polyphenols, carotenoids, terpenes, and flavonoids that act as antioxidants to protect against free radicals produced in the body. The present study was performed to explore in vivo antioxidant potential of mango peels against dyslipidemia and oxidative stress in overweight subjects. The female volunteers ( n = 31 ) between 25 and 45 years of age having a body mass index (BMI) of 25.0-29.9 (overweight) were included in this study, while participants with complications as diabetes, hypertension, cardiovascular, and liver diseases were excluded. The treatment group consumed 1 g mango peel powder for 84 days. The subjects were analyzed for biochemical analysis, antioxidant status, and anthropometric measurements at baseline and end of the study period. Further, at the end of study, the safety evaluation tests were also performed. The results showed that upon consumption of mango peel powder, low-density lipoproteins (LDL), cholesterol, triglyceride, urea, and creatinine levels were decreased and high-density lipoprotein (HDL) level was increased ( P ≤ 0.05 ), while thiobarbituric acid reactive substances (TBARS) showed increased antioxidant status ( P ≤ 0.05 ) which suggests that mango peels have a strong management potential against oxidative stress and dyslipidemia in obese subjects.

Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

“…According to Arshad et al [37], the use of mango peel powder can improve lipid profiles in obese women. They also found important antioxidant activity, suggesting that mango peels have a considerable potential to control oxidative stress and dyslipidemia in obese individuals.…”

Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

“…Studies in high-cholesterol-fed rats found that consumption of lupeol and its derivatives can reduce the TC triglyceride, and decrease the activity of cardiac enzymes like LDH, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), thereby suggesting the cardioprotective effects of triterpenoids ( Sudhahar et al, 2007 ). Mango peel powder has shown significant cardioprotective effects in obese females by protecting against vascular damage caused by LDL oxidation ( Arshad et al, 2021 ). Both mango peel extract and mangiferin have been found to produce significant reductions in TG, LDL, and VLDL-cholesterol in the alloxan-induced type I diabetic rat ( Table 1 ; Mistry et al, 2023 ).…”

Polyphenols and ω-3 PUFAs: Beneficial Outcomes to Obesity and Its Related Metabolic Diseases

“…Hence, for human behavior changes, joint activities between Universities, Research Centers, Health Ministries, and others will be legally necessary constitution of Departments that could be responsible by outline joint projects and approaches for health promotion through seminars, and lectures to implement in schools (Primary and Secondary), enterprises and families to promote healthy food cooking, sale, and intake to pave the way to reduce obesity and its RMDs prevalence (140)(141)(142)(143)(144).…”