Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

Abstract

Mango and its by-products have traditional medicinal uses. They contain diverse bioactive compounds offering numerous health benefits, including cardioprotective and metabolic properties. This study aimed to explore the impact of mango fruit and its by-products on human health, emphasizing its metabolic syndrome components. PUBMED, EMBASE, COCHRANE, and GOOGLE SCHOLAR were searched following PRISMA guidelines, and the COCHRANE handbook was utilized to assess bias risks. In vivo and in vitro studies have shown several benefits of mango and its by-products. For this systematic review, 13 studies met the inclusion criteria. The collective findings indicated that the utilization of mango in various forms—ranging from fresh mango slices and mango puree to mango by-products, mango leaf extract, fruit powder, and mangiferin—yielded many favorable effects. These encompassed enhancements in glycemic control and improvements in plasma lipid profiles. Additionally, mango reduces food intake, elevates mood scores, augments physical performance during exercise, improves endothelial function, and decreases the incidence of respiratory tract infections. Utilizing mango by-products supports the demand for healthier products. This approach also aids in environmental conservation. Furthermore, the development of mango-derived nanomedicines aligns with sustainable goals and offers innovative solutions for healthcare challenges whilst being environmentally conscious.

Evaluation of Antidiabetic Potential of Mangifera indica Leaf in Streptozotocin-Induced Type 2 Diabetic Rats: A Focus on Glycaemic Control and Cholesterol Regulation

“…Our feeding test revealed that EEMI significantly reduces food intake in rats, indicating the effects of EEMI on appetite suppression. Previous studies suggest that Mangiferin, a compound found in M. indica, may be responsible for this effect [49]. An acute oral glucose tolerance test (OGTT) showed that EEMI treatment significantly improves blood sugar control in type 2 diabetic rats.…”

Evaluation of Antidiabetic Potential of Mangifera indica Leaf in Streptozotocin-Induced Type 2 Diabetic Rats: Focus on Glycemic Control and Cholesterol Regulation

“…Our feeding test revealed that EEMI significantly reduces food intake in rats, indicating the effects of EEMI on appetite suppression. Previous studies suggest that Mangiferin, a compound found in M. indica, may be responsible for this effect [51]. An acute oral glucose tolerance test (OGTT) showed that EEMI treatment significantly improves blood sugar control in T2DM rats.…”

Navigating the Neurobiology of Migraine: From Pathways to Potential Therapies

“…These remedies have played an important role in the field, and ongoing research is being conducted to identify potential antimigraine agents [128][129][130]. Herbs and other traditional forms of treatment have been linked to the treatment of conditions such as migraine [131][132][133][134][135][136]. By investigating the properties of these herbs, researchers hope to develop more effective medicines and targeted treatments for various conditions, including migraine.…”