Therapeutic Role of Ginger (Zingiber officinale) - A Review

Kausar, Tahreem; Anwar, Sadaf; Hanan, Entesar; Yaseen, Mıfftha; Aboelnaga, Shimaa Mohammed Hasnin; Azad, Z. R. Azaz Ahmad

doi:10.9734/jpri/2021/v33i29b31584

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…and are responsible for their pharmacological and biological properties. Ginger extracts have revealed antimicrobial, antioxidant, anti-inflammatory properties, they are also used to attenuate motion sickness, gastrointestinal and menstrual disorders, asthma and headache ( Gupta and Sharma, 2014 ; Kukula-Koch et al, 2018 ; Khan et al, 2019 ; Shahrajabian et al, 2019 ; Kausar et al, 2021 ).…”

Section: Plant Extracts And/or Active Constituents With Anticonvulsan...mentioning

confidence: 99%

Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review

Knap,

Nieoczym,

Kundap

et al. 2023

Front. Mol. Neurosci.

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Traditionally, selected plant sources have been explored for medicines to treat convulsions. This continues today, especially in countries with low-income rates and poor medical systems. However, in the low-income countries, plant extracts and isolated drugs are in high demand due to their good safety profiles. Preclinical studies on animal models of seizures/epilepsy have revealed the anticonvulsant and/or antiepileptogenic properties of, at least some, herb preparations or plant metabolites. Still, there is a significant number of plants known in traditional medicine that exert anticonvulsant activity but have not been evaluated on animal models. Zebrafish is recognized as a suitable in vivo model of epilepsy research and is increasingly used as a screening platform. In this review, the results of selected preclinical studies are summarized to provide credible information for the future development of effective screening methods for plant-derived antiseizure/antiepileptic therapeutics using zebrafish models. We compared zebrafish vs. rodent data to show the translational value of the former in epilepsy research. We also surveyed caveats in methodology. Finally, we proposed a pipeline for screening new anticonvulsant plant-derived drugs in zebrafish (“from tank to bedside and back again”).

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Section: Plant Extracts And/or Active Constituents With Anticonvulsan...mentioning

confidence: 99%

Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review

Knap,

Nieoczym,

Kundap

et al. 2023

Front. Mol. Neurosci.

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“…Some recent papers showed the different aspects of ginger. The therapeutic role of ginger has been studied by Kausar et al, including antioxidant effect, anti-nausea effect, anti-inflammatory effect, anti-cancer effect, cardiovascular effect, and anti-diabetic effect ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

A critical review of Ginger’s (Zingiber officinale) antioxidant, anti-inflammatory, and immunomodulatory activities

Ayustaningwarno,

Anjani,

Ayu

et al. 2024

Front. Nutr.

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Ginger (Zingiber officinale) is a rhizome that has been used as a healthy herbal plant for years. Ginger’s chemical components are recognized to provide beneficial health effects, namely as antioxidants and anti-inflammatory agents with the potential to operate as immunomodulators. This literature review covers numerous publications concerning ginger’s immunomodulatory potential, associated with antioxidant and anti-inflammatory effects in modifying the body’s immune system. Pathophysiology of oxidative stress and inflammation were introduced before diving deep down into the herbal plants as an immunomodulator. Ginger’s antioxidant and anti-inflammatory properties are provided by gingerol, shogaols, paradol, and zingerone. Ginger’s antioxidant mechanism is linked to Nrf2 signaling pathway activation. Its anti-inflammatory mechanism is linked to Akt inhibition and NF-KB activation, triggering the release of anti-inflammatory cytokines while reducing proinflammatory cytokines. Ginger consumption as food and drink was also explored. Overall, ginger and its active components have been shown to have strong antioxidant properties and the potential to reduce inflammation. Challenges and future prospects of ginger are also elaborated for future development. Future collaborations between researchers from various fields, including chemists, biologists, clinicians, pharmacists, and the food industry, are required further to investigate the effect of ginger on human immunity. Collaboration between researchers and industry can help accelerate the advancement of ginger applications.

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Synergistic antimicrobial activity of essential oils and oleoresins of cinnamon (Cinnamomum zeylanicum), clove bud (Syzygium aromaticum) and ginger (Zingiber officinale)

Sethunga

Ranasinghe

Ranaweera

et al. 2023

Biocatalysis and Agricultural Biotechnology

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Therapeutic Role of Ginger (Zingiber officinale) - A Review

Cited by 6 publications

References 27 publications

Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review

Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review

A critical review of Ginger’s (Zingiber officinale) antioxidant, anti-inflammatory, and immunomodulatory activities

Synergistic antimicrobial activity of essential oils and oleoresins of cinnamon (Cinnamomum zeylanicum), clove bud (Syzygium aromaticum) and ginger (Zingiber officinale)

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