Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review
Bartosz Knap,
Dorota Nieoczym,
Uday Kundap
et al.
Abstract:Traditionally, selected plant sources have been explored for medicines to treat convulsions. This continues today, especially in countries with low-income rates and poor medical systems. However, in the low-income countries, plant extracts and isolated drugs are in high demand due to their good safety profiles. Preclinical studies on animal models of seizures/epilepsy have revealed the anticonvulsant and/or antiepileptogenic properties of, at least some, herb preparations or plant metabolites. Still, there is … Show more
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