Therapeutic role of curcumin in oxidative DNA damage caused by formaldehyde

Çiftçi, Gülay; Aksoy, Abdurrahman; Çenesiz, Sena; Söğüt, Mehtap Ünlü; Yarım, Gül Fatma; Nisbet, Cevat; Güvenç, Dilek; Ertekin, Ali

doi:10.1002/jemt.22485

Cited by 30 publications

(18 citation statements)

References 39 publications

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“…Curcumin also reduced the nociceptive response in both phases I and II. Ciftci et al demonstrated that Curcumin could reduce the level of MDA and significantly increase the TAC, reducing the oxidative DNA damage in cells [ 55 ]. The level of oxidative stress is partially reduced due to its scavenging potential.…”

Section: Discussionmentioning

confidence: 99%

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Bulboacă

Bolboacă

Stănescu

et al. 2017

BioMed Research International

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Objective Our study aimed to investigate the analgesic and antioxidative stress effects of Curcumin (CC) in experimental migraine induced by Nitroglycerin (NTG) on rats, compared with Indomethacin (ID) and Propranolol (PP) treatments. Material and Methods Five groups of 10 rats treated i.p. were investigated: control group (healthy rats) injected with saline solution (0.9%), NTG-control group injected with NTG (1 mg/100 gbw, bw = body weight), and three groups with pretreatment applied 30 min previous to the formalin test (NTG + CC group: Curcumin (10 mg/100 gbw), NTG + PP group: Propranolol (100 μg/100 gbw), and NTG + ID group: Indomethacin (0.5 mg/100 gbw)). Formalin test was performed and number of flinches and shakes were counted. Several oxidative stress parameters were also assessed. Results The smallest values of malondialdehyde (MDA), nitric oxide (NOx), and total oxidative status (TOS) were observed on NTG + CC with significant differences as compared with the control group (p < 0.0001). The group pretreated with Curcumin proved significantly smaller number of flinches and shakes compared with both NTG + PP and NTG + ID. Conclusion Our study demonstrates a superior activity of Curcumin not only versus control, but also versus Propranolol and Indomethacin.

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Section: Discussionmentioning

confidence: 99%

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Bulboacă

Bolboacă

Stănescu

et al. 2017

BioMed Research International

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“…Much research has shown that curcumin can efficiently protect cells from H 2 O 2 -induced oxidative cell injury [ 38 , 48 ]. Due to its antioxidant potential, curcumin was shown to have the ability to reduce lipid peroxidation and DNA damage, while increasing the level of vitamin C, vitamin E, and total anti-oxidant capacity [ 49 , 50 ]. Furthermore, curcumin has been shown to induce phase II metabolism while suppressing phase I metabolizing enzymes such as renal ornithine decarboxylase [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of the Multifaceted Chemopreventive Activity of Curcumin Against the Carcinogenic Potential of the Food Additive, KBrO3

Obaidi

Higgins

Bahar

et al. 2018

CPD

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Background: Potassium bromate (KBrO3), a food additive, has been used in many bakery products as an oxidizing agent. It has been shown to induce renal cancer in many in-vitro and in-vivo experimental modelsObjectives: This study evaluated the carcinogenic potential of potassium bromate (KBrO3) and the chemopreventive mechanisms of the anti-oxidant and anti-inflammatory phytochemical, curcumin against KBrO3-induced carcinogenicity.Method: Lactate dehydrogenase (LDH) cytotoxicity assay and morphological characteristics were used to assess curcumin's cytoprotective potential against KBrO3 toxicity. To assess the chemopreventive potential of curcumin against KBrO3-induced oxidative insult, intracellular H2O2 and the nuclear concen-tration of the DNA adduct 8-OHdG were measured. PCR array, qRT-PCR, and western blot analysis were used to identify dysregulated genes by KBrO3 exposure. Furthermore, immunofluorescence was used to evaluate the ciliary loss and the disturbance of cellular tight junction induced by KBrO3.Results: Oxidative stress assays showed that KBrO3 increased the levels of intracellular H2O2 and the DNA adduct 8-OHdG. Combination of curcumin with KBrO3 efficiently reduced the level of H2O2 and 8-OHdG while up-regulating the expression of catalase. PCR array, qRT-PCR, and western blot analysis revealed that KBrO3 dysregulated multiple genes involved in inflammation, proliferation, and apoptosis, namely CTGF, IL-1, and TRAF3. Moreover, qRT-PCR and immunofluorescence studies showed that KBrO3 negatively affected the tight junctional protein (ZO-1) and induced a degeneration of primary ciliary proteins. The negative impact of KBrO3 on cilia was markedly repressed by curcumin.Conclusion: Curcumin could potentially be used as a protective agent against carcinogenicity of KBrO3.

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“…Our findings are also consistent with previous reports. For instance, curcumin has been reported to provide protection against the effect of a number of different oxidative molecules (21,23,24). in the formaldehyde group as compared to controls.…”

Section: Discussionmentioning

confidence: 99%

“…In our group, significantly increased renal MDA levels were found in the formaldehyde group, suggesting that formaldehyde may cause tissue damage through oxidative stress. Also, previous reports showed that formaldehyde may oxidize other structural and vital molecules such as certain other proteins and nucleic acids, in addition to lipids(20)(21)(22).…”

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confidence: 99%

Protective Effects of Curcumin against Formaldehyde-induced Renal Toxicity in Rats

Şener¹,

Uygur²,

Kurt³

et al. 2015

West Indian Med J

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Objectives: To explore the protective effects of curcumin against renal injury induced by formaldehyde in rats. Materials and Methods: A total of 21 male Sprague-Dawley rats were included. The animals were divided into three groups. The control group, received 10 ml/kg of physiological saline intragastrically and intraperitoneally on a daily basis. The formaldehyde group were given 10 ml/kg of physiological saline intragastrically plus 10 mg/kg of formaldehyde intraperitoneally. The formaldehyde+curcumin group, received 10 mg/kg of intraperitoneal formaldehyde daily as well as 100 mg/kg of curcumin intragastrically. After the completion of 14 days, the kidneys were removed. Tissue microscopic examination was performed with Hematoxylin-Eosin and Periodic Acid Schiff staining. Also, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities and malondialdehyde (MDA) and nitric oxide (NO) levels were measured in tissue samples. Results: Formaldehyde induced renal injury. The degenerative tissue changes in the formaldehyde+curcumin group seemed to regress, exhibiting similar characteristics to those of the controls. MDA, XO and NO were significantly higher in formaldehyde group than in controls, while a significant reduction occurred in SOD, CAT and GSH-Px activities in the formaldehyde group. Also, renal tissue MDA, XO and NO were significantly lower in the formaldehyde+curcumin group than in the formaldehyde group, while tissue SOD, CAT, and GSH-Px activities were significantly higher. Conclusions: Curcumin improved the formaldehyde-induced renal degeneration. Also, curcumin was found to prevent the reduction in SOD, CAT, and GSH-Px activity, while preventing MDA, XO and NO levels, exhibiting a protective effect against the formaldehyde induced oxidative renal injury.

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Therapeutic role of curcumin in oxidative DNA damage caused by formaldehyde

Abstract: In conclusion, the oxidative stress caused by formaldehyde exposure was reduced with the application of curcumin.

Cited by 30 publications

References 39 publications

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Identification of the Multifaceted Chemopreventive Activity of Curcumin Against the Carcinogenic Potential of the Food Additive, KBrO3

Protective Effects of Curcumin against Formaldehyde-induced Renal Toxicity in Rats

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