Protective Effects of Curcumin against Formaldehyde-induced Renal Toxicity in Rats

Şener, Ümit; Uygur, Ramazan; Kurt, Özgür; Caglar,; Gelincik, Ibrahim; Gürel, Ali; Erdoğan, Hidayet Metin

doi:10.7727/wimj.2015.385

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Formaldehyde causes lipid peroxidation by reducing the activity of superoxide dismutase and glutathione peroxidase so that the concentration of malondialdehyde increases. [29][30][31] Research in formaldehyde-induced rats was shown to increase malondialdehyde levels. 24 The absence of a significant difference in malondialdehyde levels in this study showed that the administration of Caesalpinia sappan L. extract during the 28 days of intervention has not been able to suppress the lipid peroxidation process caused by inhaled formaldehyde.…”

Section: Effect Of Caesalpinia Sappan L Ethanol Extract On Blood Seru...mentioning

confidence: 99%

Supplementation of Caesalpinia Sappan L. Extract to Increase Superoxide Dismutase Activity and Suppress Malondialdehyde Levels in Sprague Dawley Exposed to Inhaled Formaldehyde

Nurullita,

Susilaningsih,

Suwondo

et al. 2023

Pharmacogn J.

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Introduction:It is not yet known how Caesalpinia sappan L. extract (CSE) affects the activity of SOD and MDA levels in rats exposed to inhaled formaldehyde. Method: This true experimental study in vivo uses a randomized post-test-only control group design. The subjects were male Sprague Dawley, 2-4 months old, weight 200-300 grams, a total of 30 heads divided into 6 experimental groups. The treatment group was given CSE at doses of 0, 100, 400, and 1000 g/kg BW for 28 days, and exposed to inhaled formaldehyde for 2 weeks, and 8 hours/day. SOD and MDA were measured using the ELISA kit. Statistical analysis used Kruskall Wallis, Mann Whitney, and rank spearman tests with α= 5%. Results: The highest average SOD was in the CSE 1000 group and the lowest was in the negative control group. The highest average MDA levels were in the negative control group and the lowest was in the positive control group. The difference in SOD levels between groups with a p-value = 0.016, while the difference in MDA between groups has a p-value of 0.915. the p-value of the relationship between SOD levels and MDA levels is 0.02 (correlation coefficient = -0.422). Conclusion: Caesalpinia sappan L. extract can increase the activity of superoxide dismutase enzymes but has not been able to suppress malondialdehyde levels. There was an association of increased superoxide dismutase enzyme activity with decreased malondialdehyde levels in Sprague Dawley exposed to inhaled formaldehyde

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Section: Effect Of Caesalpinia Sappan L Ethanol Extract On Blood Seru...mentioning

confidence: 99%

Supplementation of Caesalpinia Sappan L. Extract to Increase Superoxide Dismutase Activity and Suppress Malondialdehyde Levels in Sprague Dawley Exposed to Inhaled Formaldehyde

Nurullita,

Susilaningsih,

Suwondo

et al. 2023

Pharmacogn J.

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“…Previous studies showed that compounds, including exogenous FA scavengers (resveratrol, Res [222] ), Curcumin (Cur), [223,224] EGCG, and endogenous FA scavengers (Co‐enzyme Q10 (Q10), [12] melatonin (MT), [225] and glutathione (GSH) [226–228] ), can have spontaneous reactions with FA (Figure 5b). Furthermore, these chemicals have been found to inhibit Aβ oligomerization and fibrillation in vitro , and reduce SP formation, which was associated with improvements in cognition in AD animal models [162,229–234] .…”

Section: New Drug For Targeting Aβ Dimersmentioning

confidence: 99%

Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives

2021

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Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain. However, medicines targeting amyloid‐beta (Aβ) have not achieved the expected clinical effects. This review focuses on the formation mechanism of the Aβ dimer (the basic unit of oligomers and fibrils) and its tremendous potential as a drug target. Recently, age‐associated formaldehyde and Aβ‐derived formaldehyde have been found to crosslink the nontoxic Aβ monomer to form the toxic dimers, oligomers and fibrils. Particularly, Aβ‐induced formaldehyde accumulation and formaldehyde‐promoted Aβ aggregation form a vicious cycle. Subsequently, formaldehyde initiates Aβ toxicity in both the early‐and late‐onset AD. These facts also explain why AD drugs targeting only Aβ do not have the desired therapeutic effects. Development of the nanoparticle‐based medicines targeting both formaldehyde and Aβ dimer is a promising strategy for improving the drug efficacy by penetrating blood‐brain barrier and extracellular space into the cortical neurons in AD patients.

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Effects of curcumin on lipid peroxidation and antioxidant enzymes in kidney, liver, brain and testis of mice bearing Ehrlich Solid Tumor

Nisari

Yılmaz

Ertekın

et al. 2020

Postepy Hig Med Dosw

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Introduction: Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study was performed to investigate effects of curcumin on lipid peroxidation and antioxidant enzymes in tissues of mice bearing Ehrlich solid tumor. Materials and Methods: Forty mice were distributed to four groups as healthy control and treatments that received 1x106 Ehrlich ascites tumor (EAT) cells and EAT cells plus 25 mg/kg/day or 50 mg/kg/day curcumin with a single subcutaneous injection. The liver, kidney, brain and testis tissues were collected for the MDA, SOD and CAT analyses. Results: Tumor development increased MDA levels in liver (p=0.001), kidney (p<0.001) and testis (p<0.01) and curcumin reduced liver MDA. Liver and kidney SOD activities were increased by both levels of curcumin (p=0.001) but 50 mg/kg/day curcumin increased brain SOD activity (p<0.001). The kidney CAT activity was increased by 50 mg/kg/day curcumin (p<0.001). Discussion: This study showed that curcumin suppresses tumor progression, and alleviates the lipid peroxidation and improves antioxidant status in the tissues of solid tumor-bearing mice.

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Protective Effects of Curcumin against Formaldehyde-induced Renal Toxicity in Rats

Cited by 3 publications

References 30 publications

Supplementation of Caesalpinia Sappan L. Extract to Increase Superoxide Dismutase Activity and Suppress Malondialdehyde Levels in Sprague Dawley Exposed to Inhaled Formaldehyde

Supplementation of Caesalpinia Sappan L. Extract to Increase Superoxide Dismutase Activity and Suppress Malondialdehyde Levels in Sprague Dawley Exposed to Inhaled Formaldehyde

Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives

Effects of curcumin on lipid peroxidation and antioxidant enzymes in kidney, liver, brain and testis of mice bearing Ehrlich Solid Tumor

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