2022
DOI: 10.1038/s41598-022-05644-7
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Therapeutic response to leflunomide in combo therapy and monotherapy is associated to serum teriflunomide (A77 1726) levels

Abstract: There is a significant rate of therapeutic failure in rheumatoid arthritis (RA) patients treated with leflunomide (LEF). This study investigates the utility values of teriflunomide levels (A77 1726) in identifying RA patients who remained with moderate or severe disease activity after the treatment with LEF. In this cross-sectional study, we compared: (a) RA patients who achieved a DAS28-ESR ≤ 3.2, and (b) RA patients who maintained a DAS28-ESR > 3.2 after treatment. ROC curves determined the cut-off of A77… Show more

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Cited by 4 publications
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“…LEF is a prodrug that is converted in the gut and liver to teriflunomide, its active form. This conversion is almost complete such that its original form of LEF is practically undetectable in the serum [ 74 , 75 ]. LEF’s pharmacologic effectiveness is achieved by the inhibition of dihydroorotate dehydrogenase (DHODH) in the de novo synthesis of pyrimidines.…”
Section: Leflunomidementioning
confidence: 99%
“…LEF is a prodrug that is converted in the gut and liver to teriflunomide, its active form. This conversion is almost complete such that its original form of LEF is practically undetectable in the serum [ 74 , 75 ]. LEF’s pharmacologic effectiveness is achieved by the inhibition of dihydroorotate dehydrogenase (DHODH) in the de novo synthesis of pyrimidines.…”
Section: Leflunomidementioning
confidence: 99%