“…In detail in the group of patients with swelling of at least one joint, with high parameters of inflammation (mainly high C-reactive protein or erythrocyte sedimentation rate) the treatment with methotrexate should be initiated as fast as possible even when the patient does not satisfy fully criteria for RA. In this issue, this problem was addressed by Kwiatkowska [1] who elegantly reviewed the up-to-date strategies to diagnose and treat RA. The complex approach to patients with RA is obviously not restricted to patients who potentially may have RA.…”