Therapeutic response of intracranial Hodgkin's disease documented by brain scanning

Thompson, Ronald W.; DeNardo, Gerald L.

doi:10.1002/1097-0142(196911)24:5<981::aid-cncr2820240517>3.0.co;2-j

Cited by 12 publications

(1 citation statement)

References 20 publications

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“…Correspondingly, the most common clinical symptom was cranial nerve palsy, followed in frequency by headache and motor deficit [18]. Involvement of the brain parenchyma by secondary Hodgkin's disease has been reported only in terminally ill patients with disseminated, advanced disease, who also showed involvement of multiple extranodal sites, including the bone marrow [18,24]. In addition, response to therapy is usually poor in these patients [18].…”

Section: Discussionmentioning

confidence: 99%

Primary manifestation of Hodgkin's disease in the central nervous system

et al. 1998

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A 62-year-old woman presented with loss of memory and a mild hemiparesis. Neuroradiology demonstrated a left frontoparietal tumour. Biopsy specimens of this lesion revealed intracerebral Hodgkin's lymphoma, a diagnosis supported by immunohistochemical reactions of the tumour cells for the CD30 antigen. Additional cell cycle studies revealed a high proliferative activity of the tumour cells in association with absence of apoptosis. There was no evidence that overexpression of bcl-2 or Epstein-Barr virus infection was involved in the pathogenesis of this neoplasm. Lymphomas in the lung were detected 3 months later. Following neurosurgical excision, radiotherapy, and chemotherapy, the patient had no evidence of Hodgkin's disease after 13 months of follow-up.

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Section: Discussionmentioning

confidence: 99%

Primary manifestation of Hodgkin's disease in the central nervous system

et al. 1998

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Computerized axial tomography in the study of intracranial complications in hematology

Gastaut

Carcassonne

1978

Cancer

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Eighty‐eight patients with blood diseases were examined by cranial computerized axial tomography (CAT). They included 40 acute leukemias (AL), 17 Hodgkin's diseases (HD), 7 Non‐Hodgkin's lymphomas (NHL), 4 chronic leukemias (CL), 4 multiple myelomas (MM), 3 macroglobulinemias, 5 polycythemias, 3 thrombopenic purpuras and 5 various blood disorders. Among the AL, 15 p. 100 (6 cases) had parenchymal lesions that we considered as leucoblastic infiltrations (proved by histology in one patient). There was also one case with cerebral hematoma, one case with hemorrhagic encephalomalacia, two cases with toxoplasmic or iatrogenic parenchymal calcifications one case with iatrogenic cortical atrophy and one case with unaccounted parenchymal hypodense zone. Among the HD, 41 p. 100 (7 cases) had intracranial localizations (proved by histology in one patient). One patient out of 7 NHL had the same type of image. All CL cases had normal CAT. One patient with MM and another with macroglobulinemia had encephalomalacia. One patient presenting polycythemia had a sub‐dural hematoma. Finally, among the other patients there were two cases of cerebral hematoma during thrombopenic purpuras. It is suggested that CAT permits a more complete neurologic work‐up for patients with blood diseases, in conjunction with other investigations (especially CSF findings). It also permits a better knowledge of the frequency and varieties of endocranial complications in hematology, mainly in AL and lymphomas. Our preliminary findings are discussed in this article.

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Intracerebral involvement in Hodgkin's disease.A report of 6 cases and review of the literature

Cuttner

Meyer

Huang

1979

Cancer

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Intracerebral involvement in Hodgkin's disease is an unusual complication. Only 28 cases have been reported. During the past twenty-four months, we have seen six patients with intracranial involvement. Five of the six patients were male and all had mixed cellular histology. We have found the cytocentrifuge examination of the cerebrospinal fluid, brain scan, angiography, and computerized axial tomography to be the most important diagnostic examinations. We feel that intracranial disease will be seen with increasing frequency as patients are living longer.

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Therapeutic response of intracranial Hodgkin's disease documented by brain scanning

Cited by 12 publications

References 20 publications

Primary manifestation of Hodgkin's disease in the central nervous system

Primary manifestation of Hodgkin's disease in the central nervous system

Computerized axial tomography in the study of intracranial complications in hematology

Intracerebral involvement in Hodgkin's disease.A report of 6 cases and review of the literature

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