Primary manifestation of Hodgkin's disease in the central nervous system

Abstract

A 62-year-old woman presented with loss of memory and a mild hemiparesis. Neuroradiology demonstrated a left frontoparietal tumour. Biopsy specimens of this lesion revealed intracerebral Hodgkin's lymphoma, a diagnosis supported by immunohistochemical reactions of the tumour cells for the CD30 antigen. Additional cell cycle studies revealed a high proliferative activity of the tumour cells in association with absence of apoptosis. There was no evidence that overexpression of bcl-2 or Epstein-Barr virus infection was involved in the pathogenesis of this neoplasm. Lymphomas in the lung were detected 3 months later. Following neurosurgical excision, radiotherapy, and chemotherapy, the patient had no evidence of Hodgkin's disease after 13 months of follow-up.

CT and MRI Findings of Intracranial Lymphoma

“…Intracranial Hodgkin's lymphoma may mimic meningioma, although parenchymal lesions without meningeal attachment have been reported [8] ( Figs. Primary intracranial Hodgkin's lymphoma, with only a few case reports, is perhaps the rarest of all intracranial lymphomas.…”

Intra-Cranial Lesions in a Patient with Hodgkin Lymphoma

“…Intracranial relapse in the presence of systemic disease is usually treated with cranial RT and systemic chemotherapy. Primary involvement of the CNS with HD requires modification of this treatment protocol and involves consideration of surgery in combination with radiation therapy [21,22,26,30,31]. Meningeal involvement or the presence of RS cells in the CSF may warrant intrathecal therapy but the evidence to support this approach is minimal [27].…”

Intracerebral Presentation of Hodgkin Disease Mimicking Meningioma in a Young Woman

“…Until present time, 9 cases have been reported (Table 1). [2][3][4][5][6][7][8][9][10] In 1988, Ashby et al 4 described a 62-yearold man with an isolated, primary fronto-temporal HD. Since that time, 8 more cases have been reported.…”