Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases

Jiang, Qiwei; Chen, Meiwan; Cheng, Kejun; Yu, Peizhong; Xing, Wei; Shi, Zhi

doi:10.1002/med.21346

Cited by 93 publications

(58 citation statements)

References 127 publications

(182 reference statements)

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“…Alkaloids isolated from plant are commonly found to have antimicrobial properties (Jiang et al 2016). Berberine and hormone are important representatives of the alkaloid group.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of puffball(Bovistella radicata) and separation of bioactive compounds

Liu

Zeng

et al. 2017

AMB Expr

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BackgroundTo test the antimicrobial activity of different extracts and fermentation broth from puffball(Bovistella radicata), the different extracts and fermentation broth of puffball were prepared, the active fraction was investigated by UPLC–UV–MS and semi-preparative chromatograph.ResultsThrough zones of inhibition (ZOI) and minimum inhibitory concentrations (MIC) tests, the supernatant of fermentation possessed best antimicrobial activity in all extracts whose MIC value is 31.2 μg/ml against T. rubrum, T. mentagrophytes, S. aureus and P. aeruginosa. And ZOI value is 29.01, 21.02, 35.02, 28.01 mm against T. rubrum, T. mentagrophytes, S. aureus and P. aeruginosa. Then we compare the puffball fermentation supernatant with blank contrast by LC–MS. There are the characteristic peaks named PBR-1 and PBR-2 with the puffball fermentation supernatant, the separation of compound PBR-1 and PBR-2 was done on semi-preparative C18 column and the MIC and ZOI of compound PBR-1 and PBR-2 are 15.6 μg/ml and 34 mm with the antifungal test.ConclusionsThe fermentation supernatant and compound PBR-1 and PBR-2 have promising antifungal activity against T. rubrum and T. mentagrophytes.

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“…Alkaloids isolated from plant are commonly found to have antimicrobial properties (Jiang et al 2016). Berberine and hormone are important representatives of the alkaloid group.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of puffball(Bovistella radicata) and separation of bioactive compounds

Liu

Zeng

et al. 2017

AMB Expr

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“…The alkaloids have been used as stimulants [33][34][35]. Several drugs used for treatment of cancer, neurological, cardiovascular and several other health related disorders in human are alkaloids [36]. We have detected presence of alkaloids in both O. indicum and M. pachycarpa and their medicinal use may lie in these phytochemicals.…”

Section: Discussionmentioning

confidence: 89%

Phytochemical and TLC Profiling of Oroxylum indicum and Milletia pachycarpa

M¹,

J²

2015

Saha, J Plant Biochem Physiol

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The humans have used medicinal plants for healthcare since the time immemorial. The systematic phytochemical analysis of traditionally used medicinal plants is needed to establish their use as medicine. Oroxylum indicum and Milletia pachycarpa have been used in India and China to treat various health related disorders. Therefore it was decided to undertake phytochemical and Thin Layer Chromatography (TLC) profiling of different extracts of Oroxylum indicum and Milletia pachycarpa using standard procedures. The dried powder of stem bark of Oroxylum indicum and root bark of Milletia pachycarpa was sequentially extracted in chloroform, ethanol and water. The dried extract of each plant was phytochemically analyzed for the presence of alkaloids, flavonoids, cardiac glycosides, phytosterols, saponins, tannins steroids and phlobatannins. Each extract from both plants was processed for TLC profiling on silica gel using various solvent combinations as mobile phase. The phytochemical analysis showed the presence of alkaloids in chloroform and ethanol extracts, whereas alkaloids were absent in aqueous extract of both Oroxylum indicum and Milletia pachycarpa. The flavonoids were observed in all extracts of both plants. However, cardiac glycosides were absent in the aqueous extract of Milletia pachycarpa. The saponins were detected in all the extracts of both plants except the chloroform extract of Oroxylum indicum. The tannins could not be detected in the aqueous extract of M. pachycarpa. The phlobatannins were absent in all extracts of both plants. Steroids exhibiting a wide variety of biological activity [8]. Almost every part of this tree possesses medicinal properties and has been used in several traditional Ayurvedic and folk medicines [18]. O. Indicum has been reported to possess several medicinal properties including analgesic, antibacterial, anti-inflammatory, anticancer, antioxidant [19][20][21][22][23]. Therefore, an attempt has been made to study the phytochemical constituents of Milletia pachycarpa and Oroxylum indicum. Materials and Methods Preparation of the extractThe non-infected stem bark of O. indicum was collected from Champhai whereas root bark of Milletia pachycarpa was collected from Kolasib district of Mizoram, India during the dry season in the month of January. The identification of plant was done by the Department of Horticulture and Aromatic and Medicinal Plants, Mizoram University, Aizawl, India. The barks of both plants was washed thoroughly with clean water and allowed to shade dry at room temperature in the dark in clean and hygienic conditions. The dried barks of both plants were separately powdered using an electrical grinder at room temperature. The powdered bark of O. indicum stem or root bark of M. pachycarpa was sequentially extracted with petroleum ether, chloroform, ethanol and distilled water according to increase in polarity using a Soxhlet apparatus until the solvents became colourless [24]. The liquid extracts were concentrated by evaporating their liquid contents using ...

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“…Hence, it can be accomplished that the hepatoprotective effects of EEBs could be attributed to its various phyto-constituents and might be responsible for suppressing the toxicity initiated by Aflatoxin B 1 . Alkaloids were also known for its anti-tumour property (Corvalan et al, 1988;Jiang et al, 2016). From the experimental findings, it can be inferred that concurrent administration of AFB 1 along with EEBs has significantly reversed the altered levels of LPO and antioxidant enzymes.…”

Section: Advances In Animal and Veterinary Sciences May 2016 | Volumementioning

confidence: 99%

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

Mishra¹,

Tandon²,

Dhama³

et al. 2016

Adv. Anim. Vet. Sci.

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| We have investigated the protective effect of oral administration of the ethanolic extract of Bougainvillea spectabilis leaves against aflatoxin B 1 (AFB 1 ) induced hepatic injuries among male Swiss albino mice. AFB 1 exposure has significantly increased (P< 0.05) the lipid peroxidase activity and decreased the activities of various antioxidant enzymes viz. superoxide dismutase (57.58%), catalase (24.14%), glutathione peroxidase (44.21%), glutathione S-transferase (44.07%) and glutathione reductase (13.51%). It also declined the level of ascorbic acid, reduced glutathione and protein contents by 47%, 34% and 24% respectively. It markedly decreased lipid peroxidation (TBARS level) with concomitant stimulation (P < 0.05) of antioxidants (enzymatic and non -enzymatic both). HPTLC analysis revealed availability of sufficient amount of flavonoids, alkaloids and phenolic compounds in the extract of B. spectabilis leaves might be responsible for the improved efficiency of antioxidant system and subsequent protection from aflatoxicity.

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Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases

Cited by 93 publications

References 127 publications

Antimicrobial activity of puffball(Bovistella radicata) and separation of bioactive compounds

Antimicrobial activity of puffball(Bovistella radicata) and separation of bioactive compounds

Phytochemical and TLC Profiling of Oroxylum indicum and Milletia pachycarpa

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

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