Therapeutic potential of some Medicinal plants on wound healing

Sarkar, Bhanumati; Jana, Sandip Kumar; Kasem, Sk. Abul; Behera, Biplab Kumar

doi:10.52756/ijerr.2016.v2.001

Cited by 24 publications

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“…However, the primary hurdle for their widespread acceptance is the lack of rigorous standardization and documentation. Ancient medicinal texts often hint at the enhanced efficacy of polyherbal formulations over individual herbs (Bhattacharjee, 2001;Sarkar et al, 2016;Hajare et al, 2023). This synergy in polyherbal mixes can potentially amplify therapeutic benefits.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Polyherbal Tablets: A Comprehensive Assessment of Pharmacological Activity

Dhakar,

Tare

2023

IJERR

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Azadirachta indica, Allium sativum and Annona squamosa are widely recognized medicinal plants with significant therapeutic potential. Individually, each of these plants has been historically acclaimed for its antidiabetic properties, but the synergistic effect of a combined formulation has remained largely unexplored. This research aims to evaluate the antidiabetic potential of a polyherbal formulation consisting of these three plants in streptozotocin-induced diabetic rats. The polyherbal formulation was prepared using ethanolic extracts of the leaves of Azadirachta indica, bulbs of Allium sativum, and leaves of Annona squamosa. The formulation was standardized as per the World Health Organization's guidelines for herbal materials. Acute toxicity studies established its safety profile, showing no toxicity at doses up to 2000 mg/kg. Antidiabetic activity was assessed in streptozotocin-induced diabetic rats, and the results demonstrated a remarkable reduction in blood glucose levels, comparable to the standard drug glibenclamide. Furthermore, biochemical evaluations corroborated the formulation's efficacy, which was also substantiated through histopathological assessments of the liver and pancreas. In conclusion, the polyherbal formulation exhibits profound antidiabetic activity, suggesting its potential as an effective herbal remedy for diabetes management.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Polyherbal Tablets: A Comprehensive Assessment of Pharmacological Activity

Dhakar,

Tare

2023

IJERR

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“…Traditional healers have gained importance recently for historical and cultural reasons, particularly in developing nations with scarce access to healthcare (Sarkar, 2016;Bhattacharjee, 2021). Traditional therapy and medications are still widely used to treat a variety of ailments (Sarkar et al, 2016;Banerjee et al, 2014;Sanyal et al, 2018;Kar et al, 2022). The lack of a scientific study of medicinal herbs to verify their usage may result in significant harmful effects (Maiti et al, 2013;Fitzgerald et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

A comprehensive characterization and therapeutic properties in ripened Noni fruits (Morinda citrifolia L.)

Sarkar¹,

Bhattacharya

Chen

et al. 2022

IJERR

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In this study, methanolic extracts from fresh ripening noni fruits (NFs) (Morinda citrifolia) were analyzed using GC-MS, FTIR, and XRD methods. Comprehensive assessments were studied by proximate analysis (PA), higher heat value (HHV), bulk density (BD) and swelling index (SI). The qualitative analysis of the ripening NFs extracts in various solvents, including distilled water, chloroform, dimethyl sulfoxide (DMSO), dimethyl formamide, and methanol, revealed positive results for starch, terpenoids, saponin, and cardiac glycosides. The percentages of volatile matter, ash content and fixed carbon in PA are 78.799±0.592, 7.18±0.044 and 14.02±0.553, respectively. To use biomass as energy, PA is essential that burns in a gaseous state (volatile matter), solid-state (fixed carbon), and inorganic waste material (ash). It is important to consider the HHV of 17.185±0.103 MJ/kg when estimating the potential for energy recovery from the fruit's biomass. Compositional analysis (CA) was used to determine the percentages of the extractive contents (4.497±0.346), cellulose (33.114±0.261), lignin (9.569±0.399), and hemicellulose (17.89±0.608), all of which have substantial antibacterial properties. Our research looked at its BD (0.312±0.001g/cm3) and SI (1.535±0.022%), resulting in increased susceptibility of the biomass to microbial activity. FTIR and XRD reveal C-O, O-H, N-H, O=C=O, C-H, and O-H linkages with solid lattice spacing. It helps to determine how a substance will interact with biological tissue following implantation. However, no research documents were found in any literature about the oil from noni fruits for the purpose of external pain relief. Advice on using NFs oil for pain treatment comes from our field study of a woman who is 80 years old. In ripening NFs extract, GC-MS analysis identified 100 phytochemicals, including D-limonene, 3-carene, gamma-terpinene, methyl eugenol, caryophyllene, hentriacontane etc. GCMS and virtual screening-cum-molecular docking studies have been done and reported first time to check the documentation and look for caryophyllene that could be used for pain-relieving properties. These compounds have been shown to have antioxidant, antimicrobial, anticancer, inflammation in the brain and oxidative stress-related effects. Our research confirms the bioactive potential of ripening NFs as an alternative medication source.

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Standardization and Wound-Healing Activity of Petroleum, Ethanolic and Aqueous Extracts of Ficus Benghalensis Leaves

et al. 2021

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Therapeutic potential of some Medicinal plants on wound healing

Cited by 24 publications

References 0 publications

Therapeutic Potential of Polyherbal Tablets: A Comprehensive Assessment of Pharmacological Activity

Therapeutic Potential of Polyherbal Tablets: A Comprehensive Assessment of Pharmacological Activity

A comprehensive characterization and therapeutic properties in ripened Noni fruits (Morinda citrifolia L.)

Standardization and Wound-Healing Activity of Petroleum, Ethanolic and Aqueous Extracts of Ficus Benghalensis Leaves

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