Therapeutic potential of selected South African macrofungi in diabetic wound healing: An in vitro evaluation

Pringle, Nadine A.; Venter, Maryna van de; Boukes, Gerhardt J.; Koekemoer, Trevor

doi:10.1016/j.sajb.2021.01.008

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…P. tinctorius stood out as one of the fungi with the highest values of antioxidant activity, evaluated by three different methods: 2,2-di(4-tertoctylphenyl)-1-picrylhydrazyl (DPPH), 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP), with 1291.00, 519.10 and 128.30 µM Trolox (6-hydroxy-2,5,7,8-tetramethlychroman-2-carboxylic acid)/g, respectively (Table 3). Similarly, Pringle et al [87] showed that P. tinctorius ethanolic and aqueous extracts had the highest antioxidant activity among four tested fungi. It is interesting to note that the P. tinctorius ethanolic extract, at 200 µg/mL, had a similar antioxidant activity, assessed by DPPH, as catechin, a reference compound with high antioxidant capacity.…”

Section: Antioxidant Activitymentioning

confidence: 84%

“…Similarly, Pringle et al [ 87 ] showed that P. tinctorius ethanolic and aqueous extracts had the highest antioxidant activity among four tested fungi. It is interesting to note that the P. tinctorius ethanolic extract, at 200 µg/mL, had a similar antioxidant activity, assessed by DPPH, as catechin, a reference compound with high antioxidant capacity.…”

Section: The Bioactive Potential Of Pisolithusmentioning

confidence: 84%

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Exploring the Bioactive Potential of Pisolithus (Basidiomycota): Comprehensive Insights into Antimicrobial, Anticancer, and Antioxidant Properties for Innovative Applications

Oliveira,

Preto,

Santos

et al. 2024

Microorganisms

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Addressing pressing health concerns, modern medical research seeks to identify new antimicrobials to combat drug resistance, novel molecules for cancer treatment, and antioxidants for inflammation-related diseases. Pisolithus (Basidiomycota) is a ubiquitous and widely distributed fungal genus in forest ecosystems, known for establishing ectomycorrhizal associations with a range of host plants, enhancing their growth, and conferring protection against biotic and abiotic stresses. Beyond ecological applications, Pisolithus yields bioactive compounds with medicinal potential. This comprehensive review explores the transversal biological activity of Pisolithus fungi, aiming to provide a thorough overview of their antimicrobial, anticancer, and antioxidant potential. The focus is on elucidating bioactive compounds within Pisolithus to trigger further research for innovative applications. Compounds from Pisolithus displayed antimicrobial activity against a broad spectrum of microorganisms, including antibiotic-resistant bacteria. The efficacy of Pisolithus-derived compounds matched established medications, emphasizing their therapeutic potential. In anticancer research, the triterpene pisosterol stood out with documented cytotoxicity against various cancer cell lines, showcasing promise for novel anticancer therapies. Pisolithus was also recognized as a potential source of antioxidants, with basidiocarps exhibiting high antioxidant activity. In vivo validation and comprehensive studies on a broader range of compounds, together with mechanistic insights into the mode of action of Pisolithus-derived compounds, are compelling areas for future research.

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Section: Antioxidant Activitymentioning

confidence: 84%

Section: The Bioactive Potential Of Pisolithusmentioning

confidence: 84%

Exploring the Bioactive Potential of Pisolithus (Basidiomycota): Comprehensive Insights into Antimicrobial, Anticancer, and Antioxidant Properties for Innovative Applications

Oliveira,

Preto,

Santos

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

“…Diabetes is now a global epidemic disease, and the number of patients is increasing every year. , In recent years, the incidence rate of diabetes has increased significantly, affecting the health of about 425 million people around the world . Diabetic foot ulcer (DFU), also known as diabetic extremity gangrene, is a serious chronic complication of diabetes and also a significant cause of disability and death in diabetic patients .…”

Section: Introductionmentioning

confidence: 99%

Application of a Cascaded Nanozyme in Infected Wound Recovery of Diabetic Mice

Zhang

et al. 2022

ACS Biomater. Sci. Eng.

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The emergence of peroxidase (POD)-like nanozyme-derived catalytic therapy has provided a promising choice for reactive oxygen species (ROS)-mediated broad-spectrum antibacterials to replace antibiotics, but it still suffers from limitations of low therapeutic efficiency and unusual addition of unstable H2O2. Considering that the higher blood glucose in diabetic wounds provides much more numerous nutrients for bacterial growth, a cascade nanoenzymatic active material was developed by coating glucose oxidase (GOx) onto POD-like Fe2(MoO4)3 [Fe2(MoO4)3@GOx]. GOx could consume the nutrient of glucose to produce gluconic acid (weakly acidic) and H2O2, which could be subsequently converted into highly oxidative •OH via the catalysis of POD-like Fe2(MoO4)3. Accordingly, the synergistic effect of starvation and ROS-mediated therapy showed significantly efficient antibacterial effect while avoiding the external addition of H2O2 that affects the stability and efficacy of the therapy system. Compared with the bactericidal rates of 46.2–59.404% of GOx or Fe2(MoO4)3 alone on extended-spectrum β-lactamases producing Escherichia coli and methicillin-resistant Staphylococcus aureus, those of the Fe2(MoO4)3@GOx group are 98.396 and 98.776%, respectively. Animal experiments showed that the as-synthesized Fe2(MoO4)3@GOx could much efficiently promote the recovery of infected wounds in type 2 diabetic mice while showing low cytotoxicity in vivo.

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Enhanced antioxidant and anti-inflammatory activity of the extracts of Pleurotus ostreatus edible mushroom grown on Lavandula angustifolia residues

Bassi,

Benvenuti,

Mirata

et al. 2024

Food Bioscience

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Therapeutic potential of selected South African macrofungi in diabetic wound healing: An in vitro evaluation

Cited by 5 publications

References 49 publications

Exploring the Bioactive Potential of Pisolithus (Basidiomycota): Comprehensive Insights into Antimicrobial, Anticancer, and Antioxidant Properties for Innovative Applications

Exploring the Bioactive Potential of Pisolithus (Basidiomycota): Comprehensive Insights into Antimicrobial, Anticancer, and Antioxidant Properties for Innovative Applications

Application of a Cascaded Nanozyme in Infected Wound Recovery of Diabetic Mice

Enhanced antioxidant and anti-inflammatory activity of the extracts of Pleurotus ostreatus edible mushroom grown on Lavandula angustifolia residues

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