Therapeutic Potential of Saffron Crocus (Crocus sativus L.)

Selamoğlu, Zeliha; Özgen, Şenay

doi:10.24925/turjaf.v4i12.1240-1245.1066

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…[38] Günümüzde cinsel işlev bozukluğu tedavisinde kullanılan farmakolojik, nonfarmakolojik ve cerrahi yaklaşımların yanı sıra, safranın geleneksel tedavide de yerini aldığı [42] ve cinsel performans üzerindeki afrodizyak ve oksitosik etkisi ile dikkat çektiği belirlenmiştir. [43][44][45][46] Safranın kadın cinselliği üzerindeki etkisinin araştırıldığı kısıtlı sayıda çalışma olsa da, Rahmati ve ark. (2017) 18-39 yaş arası üreme çağındaki kadınlarla gerçekleştirdiği çalışmada, safran kullanılan gruptaki kadınların cinsel performanslarının anlamlı oranda iyileştiği, geliştiği görülmüştür.…”

Section: Crocus Sativusunclassified

Kadın cinsel fonksiyon bozukluklarında fitoterapi

Aygin¹,

Gül²,

Yaman³

et al. 2018

Androl Bul

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C insellik, insanlık var olduğundan bu yana yaşamın önemli bir parçasıdır ve sadece fiziksel olmayıp sosyal, kültürel ve zihinsel yönleri de olan çok boyutlu bir kavramdır. Bu kavram bireyin biyolojik cinsiyeti, cinsiyet kimliği ve cinsiyet rol davranışına göre diğer kişilerle olan etkileşiminin, sevgi ve şefkatinin de bir ifadesidir. Duyguların, düşüncelerin ve davranışların ardındaki itici güç olan cinsellik antropolojik, politik, sosyolojik ve psikolojik süreçler temelinde zevk verici ve proaktif bir etkinlik olarak yerini almaktadır. [1-5] Sağlıklı cinsel yaşamın ömür boyu sürdürülmesi istenilen bir durumdur. Ancak kadınların ve erkeklerin cinsel istek, uyarılma ya da orgazm ile ilişkili cinsel fonksiyonda sağlıklı popülasyonda bile sorunlar yaşadığı bilinmektedir. Amerika Birleşik Devletleri'nde kadınların %15-30'u, ABSTRACT Sexuality, an important and indispensable part of human life, can be adversely affected by bio-psycho-social causes, chronic diseases, and the treatments applied. Besides medical and surgical approaches, phytotherapy is also used in the treatment of sexual dysfunctions. This review article was written to share knowledge about herbal medicines such as Tribulus Terrestris,

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Section: Crocus Sativusunclassified

Kadın cinsel fonksiyon bozukluklarında fitoterapi

Aygin¹,

Gül²,

Yaman³

et al. 2018

Androl Bul

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show abstract

“…Crocus sativus is used in Asian and, in particular, Indian (Ayurveda) and Persian (Islamic) traditional medicine (ITM) as a sedative agent to strengthen the body against such stresses as trauma and anxiety, an anticonvulsant and memory enhancer, and a remedy for alleviation of chronic fatigue, depression, and inflammation [ 71 , 135 ]. This therapeutic activity of Crocus , known since the 6th century BC, has been confirmed in the most recent basic research conducted on animals (rodents) and in human clinical studies [ 134 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 ].…”

Section: Phytotherapy For Depressionmentioning

confidence: 70%

Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.

et al. 2022

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Psychotropic effect of Crocus sativus L. (family Iridaceae) biologically active chemical compounds are quite well documented and they can therefore be used in addition to the conventional pharmacological treatment of depression. This systematic review on antidepressant compounds in saffron crocus and their mechanisms of action and side effects is based on publications released between 1995–2022 and data indexed in 15 databases under the following search terms: antidepressant effect, central nervous system, Crocus sativus, cognitive impairement, crocin, crocetin, depression, dopamine, dopaminergic and serotonergic systems, picrocrocin, phytotherapy, neurotransmitters, safranal, saffron, serotonin, and biologically active compounds. The comparative analysis of the publications was based on 414 original research papers. The investigated literature indicates the effectiveness and safety of aqueous and alcoholic extracts and biologically active chemical compounds (alkaloids, anthocyanins, carotenoids, flavonoid, phenolic, saponins, and terpenoids) isolated from various organs (corms, leaves, flower petal, and stigmas) in adjuvant treatment of depression and anxiety. Monoamine reuptake inhibition, N-methyl-d-aspartate (NMDA) receptor antagonism, and gamma-aminobutyric acid (GABA)-α agonism are the main proposed mechanism of the antidepressant action. The antidepressant and neuroprotective effect of extract components is associated with their anti-inflammatory and antioxidant activity. The mechanism of their action, interactions with conventional drugs and other herbal preparations and the safety of use are not fully understood; therefore, further detailed research in this field is necessary. The presented results regarding the application of C. sativus in phytotherapy are promising in terms of the use of herbal preparations to support the treatment of depression. This is particularly important given the steady increase in the incidence of this disease worldwide and social effects.

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“…Another study carried by Salleh et al, on C. macrocarpum essential oil found out the safrole was the major component of this oil (54.5–59.5%) and demonstrated significant activity on DPPH [ 50 ]. Studies indicate that antioxidants usage can minimize the oxidative stress induced by the adverse effects of some drugs [ 51 ]. These indications create the potential for a new line in cancer therapy by treating them with antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Biological evaluation of Safrole oil and Safrole oil Nanoemulgel as antioxidant, antidiabetic, antibacterial, antifungal and anticancer

Eid

Hawash

2021

BMC Complement Med Ther

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Background Safrole is a natural compound extracted from various plants, and has shown various biological activities. The current study aimed to investigate the antioxidant, antidiabetic, antimicrobial, and anticancer activity of safrole oil and to study the influence of safrole nanoemulgel on these activities. Methods The antioxidant and antidiabetic in-vitro assays were conducted using standard biomedical methods. The safrole oil nanoemulgel was developed using a self-emulsifying technique. Then the antimicrobial activity of the safrole oil and safrole nanoemulgel were performed on different microbial species, and cytotoxicity was determined against Hep3B cancer cell lines using the MTS assay. Results Safrole oil showed moderate antioxidant activity compared with standard Trolox, with IC50 value 50.28 ± 0.44 and 1.55 ± 0.32 μg/ml, respectively. Moreover, it had potent α-amylase inhibitory activity (IC50 11.36 ± 0.67 μg/ml) compared with Acarbose (IC50 value 5.88 ± 0.63). The safrole nanoemulgel had pseudo-plastic behaviour, droplet sizes below 200 nm, a polydispersity index (PDI) below 0.3, and a zeta potential of less than − 30 mV. Safrole oil has potential antimicrobial and anticancer activities, and these activities were improved with safrole nanoemulgel. Conclusion The safrole oil may be applied for the prevention and treatment of oxidative stress, diabetes, different microbial species and cancer, and these activities could be improved by nano-carriers.

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Therapeutic Potential of Saffron Crocus (Crocus sativus L.)

Cited by 6 publications

References 30 publications

Kadın cinsel fonksiyon bozukluklarında fitoterapi

Kadın cinsel fonksiyon bozukluklarında fitoterapi

Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.

Biological evaluation of Safrole oil and Safrole oil Nanoemulgel as antioxidant, antidiabetic, antibacterial, antifungal and anticancer

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