Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

Abstract

Atherosclerotic cardiovascular disease (ASCVD) is one of the diseases with the highest morbidity and mortality globally. It causes a huge burden on families and caregivers and high costs for medicine and surgical interventions. Given expensive surgeries and failures of most conventional treatments, medical community tries to find a more cost-effective cure. Thus, attentions have been primarily focused on food or herbs. Quercetin (Qu) extracted from food, a flavonoid component, develops potentials of alternative or complementary medicine in atherosclerosis. Due to the wide range of health benefits, researchers have considered to apply Qu as a natural compound in therapy. This review is aimed to identify the antiatherosclerosis functions of Qu in treating ASCVD such as anti-inflammatory, antioxidant properties, effects on endothelium-dependent vasodilation, and blood lipid-lowering.

Suppressive effects of quercetin on hydrogen peroxide-induced caveolin-1 phosphorylation in endothelial cells

“…( 28 ) Quercetin (3,3,4,5,7-pentahydroxyflavone; Q), a flavonol-type flavonoid commonly present in fruits and vegetables, is a potential candidate for use in preventing the onset of cardiovascular diseases owing to its anti-oxidative or anti-atherosclerosis functions. ( 29 – 31 )…”

Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

“…Transfection of the miR-21 inhibitor eliminates the protective effect of kaempferol exerted on oxidative stress by reversing the enhanced activities of antioxidant enzymes such as SOD and attenuates iNOS activity and NO levels [ 209 ]. Quercetin is the most common and widely distributed flavonol compound, and daily consumption is realized in the form of plant-derived foods such as tea, onion, lettuce, broccoli, beans, and buckwheat [ 210 ]. Quercetin has a long history of exerting beneficial health effects, especially cardioprotective effects, and is associated with the ability to quench free radicals as antioxidants and to reduce the formation of atherosclerotic plaque [ 210 ].…”

“…Quercetin is the most common and widely distributed flavonol compound, and daily consumption is realized in the form of plant-derived foods such as tea, onion, lettuce, broccoli, beans, and buckwheat [ 210 ]. Quercetin has a long history of exerting beneficial health effects, especially cardioprotective effects, and is associated with the ability to quench free radicals as antioxidants and to reduce the formation of atherosclerotic plaque [ 210 ]. The anti-inflammatory properties of quercetin include the downregulation of miR-155 enhancement of the miR-21 expression, which is one of the pro-inflammatory miRNAs [ 161 ].…”

Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis

“…Quercetin is also found in fruits, nuts, and vegetables ( Stromsnes et al, 2020 ). Studies showed that quercetin has potential to treat atherosclerosis by reducing inflammation and resisting oxidative stress ( Deng et al, 2020 ). The antioxidant effects of quercetin occur first by inhibition of p47phox and p67phox activity, reducing NADPH oxidase activation to decrease ROS production ( Xiao et al, 2017 ).…”