Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis

Song, Luxia; Zhang, Jie; Peng, Runmin; Li, Qiuyi; Ju, Jianqing; Xu, Hao

doi:10.3389/fphar.2021.675999

Cited by 13 publications

(6 citation statements)

References 205 publications

(211 reference statements)

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“…After balancing oxidation and antioxidation, NO and eNOS bioavailability improved, reducing inflammation, autophagy, and apoptosis, and inhibiting the recruitment of monocytes by adhesion factors, thereby protecting endothelial cell function. By elevating high-density lipoprotein (HDL) cholesterol absorption capacity, quercetin increased HDL antioxidation and reduced lipid accumulation [22]. GBE is a multifunctional neuroprotective agent and decreases post-ischemia-reperfusion injury stress [23].…”

Section: Discussionmentioning

confidence: 99%

Use of Vasavital® in patients with diabetic retinopathy

Khramenko¹,

Umanets²,

Medvedovska³

et al. 2022

Oftalmol Zh

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Background: Diabetic retinopathy (DR) is a major cause of visual impairment or blindness among working-age adults worldwide. For years, researchers around the world have been trying to develop new effective pharmaceutical methods of treatment for preclinical and early DR. Purpose: To examine the effect of a one-month course of Vasavital on the function of the visual system and ocular hemodynamics (using ophthalmic rheography) in patients with non-proliferative and proliferative diabetic retinopathy (NPDR and PPDR, respectively). Material and Methods: Forty-seven type 2 diabetes patients with DR and moderate glycemic control were divided into those with NPDR (group 1 of 15 patients; 30 eyes) and those with PPDR (group 2 of 17 patients; 34 eyes). The control group was composed of 15 volunteers (30 eyes) of similar age having no systemic or eye disease. Patients received a one-month course of Vasavital-only therapy at a dose of one capsule twice a day as an outpatient treatment. They received visual acuity assessment, intraocular pressure measurement, ophthalmoscopy, biomicroscopy, perimetry, systemic blood pressure and pulse measurement, optical coherence tomography and fluorescein angiography, and ocular hemodynamics was assessed by ophthalmic rheography. Eleven patients (22 eyes) with NPDR and ten patients (20 eyes) with PPDR underwent electrophysiological studies of electrically evoked phosphene threshold (EEPT) and critical frequency of phosphene disappearance (CFPD), before and after a course of Vasavital treatment. Results: Patients reported that a one-month course of Vasavital was well-tolerated, with no new complaints. In addition, no side effects were observed. After treatment, the function of the photopic afferent system as assessed by light sensitivity at minutes 0 to 7 of adaptation improved by 33.3%-40% in patients with NPDR and by 27.2%-33.3% in patients with PPDR. In addition, there was a decrease in EEPT by 18% and 7.7%, respectively, and an increase in CFPD by 28.2% and 24.7%, respectively, for patients in groups 1 and 2. Moreover, ocular pulse blood filling improved by 27.7% in patients with NPDR and by 17.3% in patients with PPDR, and vascular tone in large-caliber vessels decreased by 8% in the former patients. Conclusion: A one-month Vasavital course administered to patients with DR had a positive effect on the visual system function and ocular circulation parameters, which provides grounds for the use of the Ginkgo biloba-based preparation as a monotherapy or as part of a combined treatment for initial functional changes in the visual system in DR.

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Section: Discussionmentioning

confidence: 99%

Use of Vasavital® in patients with diabetic retinopathy

Khramenko¹,

Umanets²,

Medvedovska³

et al. 2022

Oftalmol Zh

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show abstract

“…Atherosclerosis (AS) is also a severe disease that can cause vascular damage [ 120 , 121 ]. Although many drugs can treat atherosclerosis [ 122 , 123 , 124 ], their systemic administration has serious disadvantages. In particular, the proportion of therapeutic dose reaching atherosclerotic lesions is small, resulting in poor therapeutic effect.…”

Section: Mnps For Vascular Repairmentioning

confidence: 99%

Vascular Repair by Grafting Based on Magnetic Nanoparticles

et al. 2022

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Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs is strictly controlled by the size, crystallinity, uniformity, and surface properties of the synthesized particles. In this review, we summarized the classification of MNPs and their application in vascular repair. MNPs mainly use their unique magnetic properties to participate in vascular repair, including magnetic stimulation, magnetic drive, magnetic resonance imaging, magnetic hyperthermia, magnetic assembly scaffolds, and magnetic targeted drug delivery, which can significantly affect scaffold performance, cell behavior, factor secretion, drug release, etc. Although there are still challenges in the large-scale clinical application of MNPs, its good non-invasive way to participate in vascular repair and the establishment of a continuous detection process is still the future development direction.

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“…Moreover, oxidative stress can activate inflammatory mediators, leading to the development of metabolic and inflammatory diseases [ 4 ]. Studies have shown that the mechanisms of action of many natural plants in the treatment of chronic diseases are closely related to antioxidant function [ 5 ]. In China, there is a special class of natural plant raw materials that not only have the nutritional ingredients of ordinary food and can be used as diet but also have the functional ingredients of medicine and can be used as medicine.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity, flavor and physicochemical properties of FH06 functional beverage fermented by lactic acid bacteria: a promising method to improve antioxidant activity and flavor of plant functional beverage

et al. 2023

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The ability of natural plants to treat chronic diseases is closely related to their antioxidant function. Lactic acid bacteria (LAB) fermentation is an effective way to improve the nutritional value, biological activity and flavor of food. This study investigated the pH, titratable acidity, total polysaccharide, total flavone, total saponin, total polyphenol, and antioxidant activity of the FH06 beverage before and after probiotic fermentation. Results: After fermentation, FH06 had lower contents of total polysaccharides, total flavonoids, total saponins and total polyphenols but higher titratable acidity. The antioxidant activity was tested by total antioxidant capacity (FRAP method) and DPPH· scavenging ability. The FRAP value significantly increased after fermentation (P < 0.05), and the maximum increase was observed for Lactobacillus fermentum grx08 at 25.87%. For DPPH· scavenging ability, the value of all fermentations decreased, and L. fermentum grx08 had the smallest reduction at 2.21% (P < 0.05). The results of GC–MS and sensory analysis showed that fermentation eliminated bad flavors, such as grass, cassia and bitterness, and highlighted the fruit aroma and soft sour taste. Conclusion: The FRAP value and sensory flavor of FH06 fermentation by L. fermentum grx08 were significantly improved, indicating its great potential as a functional food with both strong antioxidant activity and good flavor. Graphical Abstract

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Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis

Cited by 13 publications

References 205 publications

Use of Vasavital® in patients with diabetic retinopathy

Use of Vasavital® in patients with diabetic retinopathy

Vascular Repair by Grafting Based on Magnetic Nanoparticles

Antioxidant capacity, flavor and physicochemical properties of FH06 functional beverage fermented by lactic acid bacteria: a promising method to improve antioxidant activity and flavor of plant functional beverage

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