Therapeutic Potential of Polyphenols in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Novak, Valentina; Rogelj, Boris; Župunski, Vera

doi:10.3390/antiox10081328

Cited by 25 publications

(14 citation statements)

References 159 publications

(187 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are widely distributed in plants and products of plant origin, such as tea and wine, and represent the most abundant group of polyphenolic compounds in daily diets [184,185]. Hence, it comes with no surprise that they are one of the most studied dietary supplements from the aspect of their therapeutic potential in neurodegenerative diseases [182,[186][187][188][189][190][191][192].…”

Section: Flavonols As Therapeutic Option In Neurodegenerative Diseasesmentioning

confidence: 99%

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

et al. 2021

View full text Add to dashboard Cite

Neurodegenerative diseases are one of the leading causes of disability and death worldwide. Intracellular transduction pathways that end in the activation of specific transcription factors are highly implicated in the onset and progression of pathological changes related to neurodegeneration, of which those related to oxidative stress (OS) and neuroinflammation are particularly important. Here, we provide a brief overview of the key concepts related to OS- and neuroinflammation-mediated neuropathological changes in neurodegeneration, together with the role of transcription factors nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-κB (NF-κB). This review is focused on the transcription factor p53 that coordinates the cellular response to diverse genotoxic stimuli, determining neuronal death or survival. As current pharmacological options in the treatment of neurodegenerative disease are only symptomatic, many research efforts are aimed at uncovering efficient disease-modifying agents. Natural polyphenolic compounds demonstrate powerful anti-oxidative, anti-inflammatory and anti-apoptotic effects, partially acting as modulators of signaling pathways. Herein, we review the current understanding of the therapeutic potential and limitations of flavonols in neuroprotection, with emphasis on their anti-oxidative, anti-inflammatory and anti-apoptotic effects along the Nrf2, NF-κB and p53 pathways. A better understanding of cellular and molecular mechanisms of their action may pave the way toward new treatments.

show abstract

Section: Flavonols As Therapeutic Option In Neurodegenerative Diseasesmentioning

confidence: 99%

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It seems that the scavenger activity is related by the free number of hydroxyls and conjugation of side chains to aromatic rings [ 111 ]. Several studies performed in ALS animal models demonstrated that polyphenols have a neuroprotective role [ 112 ]. Flavonoids are the major of phenolic compounds.…”

Section: Discussionmentioning

confidence: 99%

Amyotrophic Lateral Sclerosis: A Diet Review

D’Antona

Caramenti

Porro

et al. 2021

Foods

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is a fatal disease related to upper and lower motor neurons degeneration. Although the environmental and genetic causes of this disease are still unclear, some factors involved in ALS onset such as oxidative stress may be influenced by diet. A higher risk of ALS has been correlated with a high fat and glutamate intake and β-methylamino-L-alanine. On the contrary, a diet based on antioxidant and anti-inflammatory compounds, such as curcumin, creatine, coenzyme Q10, vitamin E, vitamin A, vitamin C, and phytochemicals could reduce the risk of ALS. However, data are controversial as there is a discrepancy among different studies due to a limited number of samples and the many variables that are involved. In addition, an improper diet could lead to an altered microbiota and consequently to an altered metabolism that could predispose to the ALS onset. In this review we summarized some research that involve aspects related to ALS such as the epidemiology, the diet, the eating behaviour, the microbiota, and the metabolic diseases. Further research is needed to better comprehend the role of diet and the metabolic diseases in the mechanisms leading to ALS onset and progression.

show abstract

“…Earlier studies suggested that polyphenols (e.g., resveratrol, curcumin, epigallocatechin gallate, quercetin, and phenolic acids), which can be found in fruits, vegetables, coffee, tea, and whole grains, may have a promising neuroprotective effect in ALS. It was observed, in vivo and in vitro , that these bioactive compounds may have the potential to regulate mitochondrial biogenesis, improve energy metabolism, reduce toxic protein aggregation, reduce microglia and astrocytes inflammation, and improve motor functions and survival ( Solanki et al., 2015 ; Novak et al., 2021 ).…”

Section: Diet Microbiome and Alsmentioning

confidence: 99%

A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men

Martin

Battistini

Sun

2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is a severely debilitating disease characterized by progressive degeneration of motor neurons. ALS etiology and pathophysiology are not well understood. It could be the consequences of complex interactions among host factors, microbiome, and the environmental factors. Recent data suggest the novel roles of intestinal dysfunction and microbiota in ALS etiology and progression. Although microbiome may indeed play a critical role in ALS pathogenesis, studies implicating innate immunity and intestinal changes in early disease pathology are limited. The gastrointestinal symptoms in the ALS patients before their diagnosis are largely ignored in the current medical practice. This review aims to explore existing evidence of gastrointestinal symptoms and progress of microbiome in ALS pathogenesis from human and animal studies. We discuss dietary, metabolites, and possible therapeutic approaches by targeting intestinal function and microbiome. Finally, we evaluate existing evidence and identify gaps in the knowledge for future directions in ALS. It is essential to understanding the microbiome and intestinal pathogenesis that determine when, where, and whether microbiome and metabolites critical to ALS progression. These studies will help us to develop more accurate diagnosis and better treatment not only for this challenging disease, but also for other neurodegenerative diseases.

show abstract

Therapeutic Potential of Polyphenols in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Cited by 25 publications

References 159 publications

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

Amyotrophic Lateral Sclerosis: A Diet Review

A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men

Contact Info

Product

Resources

About