Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

Abstract

Renal cell carcinoma (RCC) is a common cancer of the urinary system. The potential therapeutic effects of certain natural products against renal cell carcinoma have been reported both in vivo and in vitro, but no reviews have been published classifying and summarizing the mechanisms of action of various natural products. In this study, we used PubMed and Google Scholar to collect and screen the recent literature on natural products with anti-renal-cancer effects. The main mechanisms of action of these products include the induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis and reduction of drug resistance. In total, we examined more than 30 natural products, which include kahweol acetate, honokiol, englerin A and epigallocatechin-3-gallate, among others, have demonstrated a variety of anti-renal-cancer effects. In conclusion, natural products may have a wider application in kidney cancer than previously believed and are potential candidates for treatment in RCC.

Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling

“…The limitation of this study includes lack of animal data to exhibit the effect of Arborinine in vivo . Our group has, thus, commenced systematic NP screening with both in vitro and in vivo models of ccRCC ( 33 ), and data regarding Arborinine are awaited.…”

Coffee diterpenes, cafestol and kahweol, display cytotoxicity and all-<i>trans</i> retinoic acid-induced superoxide generating activity-enhancing ability in U937 cells

“…1). They also attract attention as health-promoting substances such as anti-cancer (Cavin et al, 2002;Majer et al, 2005;Kim et al, 2009;Cárdenas et al, 2014;Chae et al, 2014;Park et al, 2016;Oh et al, 2018;Iwamoto et al, 2019;Makino et al, 2021;Eldesouki et al, 2022;Feng et al,, 2022), anti-angiogenic properties (Cárdenas et al, 2011;Wang et al, 2012;Moeenfard, et al, 2016), anti-inflammatory properties (Cárdenas et al, 2011), anti-Parkinson's disease (Trinh et al, 2010) and anti-osteoclastogenesis (Fumimoto et al, 2012). Therefore, these two coffee diterpenes are expected to play important roles in prevention and treatment of various diseases.…”