Pachymic acid activates TP53INP2/TRAF6/caspase‐8 pathway to promote apoptosis in renal cell carcinoma cells
Xunjia Li,
An He,
Chengxuan Liu
et al.
Abstract:While pachymic acid (PA), a key component of Poria cocos (Schw.), has demonstrated anti‐tumor effects in lung, breast, and pancreatic cancers, its impact on renal cell carcinoma (RCC) is unclear. This study evaluated the effect of PA on proliferation, migration, and apoptosis in human renal cancer A498 and ACHN cells as well as in cancer xenograft mice using wound scratch test, Western blotting, and co‐immunoprecipitation assays. In a dose‐ and time‐dependent manner, PA exhibited significant inhibition of RCC … Show more
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