Therapeutic potential of microneedles based delivery systems for the management of atopic dermatitis

Shukla, Shalini; Mamale, Kalpana Balu; Arya, Rajeshwar Kamal Kant; Kaundal, Ravinder K.; Shukla, Rahul

doi:10.1016/j.jddst.2023.104493

Cited by 5 publications

(4 citation statements)

References 126 publications

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“…Uma perspectiva de grande relevância reside no potencial do processo de administração transdérmica de medicamentos para o tratamento e prevenção de doenças crônicas (Lei et al, 2022;Abd-El-Azim et al, 2023;Lin et al, 2023;Shukla et al, 2023;Verana;Tijani;Puri, 2023). Isso se deve à capacidade das MNs de serem associadas a medicamentos encapsulados em nanoestruturas, que se dissolvem e liberam as nanopartículas contendo os princípios ativos quando aplicadas.…”

Section: Estudo Das Mnsunclassified

Produtos Naturais E Ciclodextrinas: Explorando Óleos Essenciais E Complexos De Inclusão Na Pesquisa E Desenvolvimento De Formulações Farmacêutica

Carvalho,

Almeida,

Medeiros

et al. 2023

Biotecnologia E Farmacologia: Abordagens Interdisciplinares Na Terapêutica Com Recursos Naturais

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Section: Estudo Das Mnsunclassified

Produtos Naturais E Ciclodextrinas: Explorando Óleos Essenciais E Complexos De Inclusão Na Pesquisa E Desenvolvimento De Formulações Farmacêutica

Carvalho,

Almeida,

Medeiros

et al. 2023

Biotecnologia E Farmacologia: Abordagens Interdisciplinares Na Terapêutica Com Recursos Naturais

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“…11 The MNs offer several benefits, such as enhanced bioavailability, improved efficacy, patient compliance, and painless administration. 12 In recent years, the various types of MNs, including hydrogel-based, 13 hollow, 14 coated, 15 dissolving, 16 solid, and swellable MNs, 17 have progressed for TDD of the therapeutics. patch is pricked within the skin, drug molecules penetrate the skin, diffuse through the MNs, and conclusively reach the systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

“…A unique transdermal drug delivery (TDD) platform called microneedles (MNs) is a noninvasive technique that can be utilized for managing skin ailments . The MNs offer several benefits, such as enhanced bioavailability, improved efficacy, patient compliance, and painless administration . In recent years, the various types of MNs, including hydrogel-based, hollow, coated, dissolving, solid, and swellable MNs, have progressed for TDD of the therapeutics.…”

Section: Introductionmentioning

confidence: 99%

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Khairnar,

Phatale,

Shukla

et al. 2024

Mol. Pharmaceutics

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The various kinds of nanocarriers (NCs) have been explored for the delivery of therapeutics designed for the management of skin manifestations. The NCs are considered as one of the promising approaches for the skin delivery of therapeutics attributable to sustained release and enhanced skin penetration. Despite the extensive applications of the NCs, the challenges in their delivery via skin barrier (majorly stratum corneum) have persisted. To overcome all the challenges associated with the delivery of NCs, the microneedle (MN) technology has emerged as a beacon of hope. Programmable drug release, being painless, and its minimally invasive nature make it an intriguing strategy to circumvent the multiple challenges associated with the various drug delivery systems. The integration of positive traits of NCs and MNs boosts therapeutic effectiveness by evading stratum corneum, facilitating the delivery of NCs through the skin and enhancing their targeted delivery. This review discusses the barrier function of skin, the importance of MNs, the types of MNs, and the superiority of NC-loaded MNs. We highlighted the applications of NC-integrated MNs for the management of various skin ailments, combinational drug delivery, active targeting, in vivo imaging, and as theranostics. The clinical trials, patent portfolio, and marketed products of drug/NC-integrated MNs are covered. Finally, regulatory hurdles toward benchtop-to-bedside translation, along with promising prospects needed to scale up NC-integrated MN technology, have been deliberated. The current review is anticipated to deliver thoughtful visions to researchers, clinicians, and formulation scientists for the successful development of the MN-technology-based product by carefully optimizing all the formulation variables.

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“…In addition to transdermal drug delivery, many emerging applications for microneedles have been revealed in recent years. These include an increased wound healing rate and tissue regeneration [19][20][21], treatment of dermatological diseases [22,23] and cancer [24], contraception [25], vaccine delivery [26,27], and diagnostic and monitoring health status [28,29].…”

Section: Introductionmentioning

confidence: 99%

Microneedles’ Device: Design, Fabrication, and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Macromol

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The delivery of therapeutical molecules through the skin, particularly to its deeper layers, is impaired due to the stratum corneum layer, which acts as a barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consist of an array of microscale needles. This particular biomedical device has been drawing attention due to its ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness, and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size, and composition. The design process of a microneedle device must take into account several factors, like the location delivery, the material, and the manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application to cosmetics, therapy, diagnoses, tissue engineering, sample extraction, cancer research, and wound healing, among others.

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Therapeutic potential of microneedles based delivery systems for the management of atopic dermatitis

Cited by 5 publications

References 126 publications

Produtos Naturais E Ciclodextrinas: Explorando Óleos Essenciais E Complexos De Inclusão Na Pesquisa E Desenvolvimento De Formulações Farmacêutica

Produtos Naturais E Ciclodextrinas: Explorando Óleos Essenciais E Complexos De Inclusão Na Pesquisa E Desenvolvimento De Formulações Farmacêutica

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Microneedles’ Device: Design, Fabrication, and Applications

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