Therapeutic potential of curcumin in diabetic complications

Parsamanesh, Negin; Moossavi, Maryam; Bahrami, Afsane; Butler, Alexandra E.; Sahebkar, Amirhossein

doi:10.1016/j.phrs.2018.09.012

Cited by 173 publications

(102 citation statements)

References 195 publications

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“…However, approved drugs for the treatment of cancer are usually limited by potential undesirable side effects such as hepatotoxicity, nephrotoxicity, ototoxicity, reduction in platelet counts, and myelosuppression . Curcumin, a natural polyphenolic compound and the principal coloring agent found in the rhizomes of Curcuma longa (Zingiberaceae), has several health benefits, including antioxidant , anti‐inflammatory , immunomodulatory , antiarthritic , antithrombotic , pulmonoprotective , lipid‐modifying , neuroprotective , anticancer , antidiabetic, and hepatoprotective properties. Numerous reports have indicated that curcumin is quite safe and nontoxic to humans up to doses of 12 g/day .…”

Section: Introductionmentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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Section: Introductionmentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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“…Therapeutic effects of curcumin in acute and chronic inflammatory disease have been well documented (Shehzad, Rehman, & Lee, ). Curcumin has been reported to exert therapeutic effects against a range of diseases including cancer (Mirzaei et al, ), osteoarthritis (Panahi, Rahimnia, et al, 2014; Sahebkar & Henrotin, ), anxiety and depression (Esmaily et al, ; Panahi, Badeli, Karami, & Sahebkar, ), dyslipidemia (Cicero et al, ; Ganjali et al, ; Panahi et al, ), metabolic syndrome (Panahi, Hosseini, et al, 2015; Panahi, Khalili, Hosseini, Abbasinazari, & Sahebkar, ), respiratory diseases (Lelli, Sahebkar, Johnston, & Pedone, ), nonalcoholic fatty liver disease (Panahi et al, ; Zabihi, Pirro, Johnston, & Sahebkar, ), type 2 diabetes (Panahi et al, ; Parsamanesh, Moossavi, Bahrami, Butler, & Sahebkar, ), ulcerative colitis (Masoodi et al, ), and systemic lupus erythematosus (Momtazi‐Borojeni et al, ).…”

Section: Introductionmentioning

confidence: 99%

Impact of curcumin on toll‐like receptors

Boozari

Butler²,

Sahebkar

2019

Journal Cellular Physiology

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Toll‐like receptors (TLRs) have a pivotal role in the activation of innate immune response and inflammation. TLRs can be divided into two subgroups including extracellular TLRs that recognize microbial membrane components (TLR1, 2, 4, 5, 6, and 10), and intracellular TLRs that recognize microbial nucleic acids (TLR3, 7, 8, and 9). Curcumin is a dietary polyphenol from Curcuma longa L. that is reputed to have diverse biological and pharmacological effects. Extensive research has defined the molecular mechanisms through which curcumin mediates its therapeutic effects. One newly defined and important target of curcumin is the TLR, where it exerts an inhibitory effect. In the current study, we focus upon the TLR antagonistic effect of curcumin and curcumin's therapeutic effect as mediated via TLR inhibition. The available evidence indicates that curcumin inhibits the extracellular TLR 2 and 4 and intracellular TLR9 and thereby exerts a therapeutic effect in diseases such as cancer, inflammation, infection, autoimmune, and ischemic disease. Curcumin effectively modulates the TLR response and thereby exerts its potent therapeutic effects.

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“…Curcumin is a natural phenolic compound that has been shown to be effective in cancer treatment [3,4]. In addition, it has been reported to have antioxidant [5], anti-inflammatory [6,7], liver protection [8], analgesia and antiarthritis [9], lipid modification [10,11], immune regulation [12,13], and antidiabetic [14,15] properties. e above pharmacological properties are attributed to the reactive functional groups in the curcumin chemical structure.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma

Zhang

et al. 2019

BioMed Research International

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Curcumin has been shown to have anticancer effects in a variety of tumors. However, there are fewer studies on the role of curcumin in endometrial carcinoma (EC). The purpose of this experiment was to examine the inhibitory effect of curcumin on endometrial carcinoma cells and ERK/c-Jun signaling pathway. We first predicted the mechanism of action of curcumin on endometrial carcinoma by network pharmacology. Then, we found that curcumin can decrease the cell viability of Ishikawa cells, inhibit the migration of cancer cells, induce apoptosis, and cause cell cycle arrest in the S phase. For molecular mechanism, curcumin reduced the mRNA expression levels of ERK2 and JUN genes and inhibited the phosphorylation of ERK and c-Jun. This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity.

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Therapeutic potential of curcumin in diabetic complications

Cited by 173 publications

References 195 publications

Biological properties of metal complexes of curcumin

Biological properties of metal complexes of curcumin

Impact of curcumin on toll‐like receptors

Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma

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