Therapeutic potential of curcumin in endometrial disorders: Current status and future perspectives

Singh, Apoorva; Dasgupta, Sanjukta; Bhattacharya, A.; Mukherjee, Gayatri; Chaudhury, Koel

doi:10.1016/j.drudis.2021.11.010

Cited by 5 publications

(4 citation statements)

References 83 publications

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“…These findings highlight the potential therapeutic implications of curcumin, although further research is needed to validate and elucidate the underlying mechanisms [170]. Evidence supports that a dietary curcumin supplement, alongside standard therapies for patients with endometrial disorders, leads to optimal outcomes and a significant reduction in pain-related symptoms without any indications of systemic toxicity [174]. That being said, curcumin's clinical application is hindered by its instability and low bioavailability.…”

Section: Curcuminmentioning

confidence: 99%

Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies

d’Otreppe,

Patino-García,

Piekos

et al. 2024

Endocrines

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Adenomyosis (ADM) is a multifaceted uterine pathology characterized by the ectopic infiltration of endometrial tissue into the myometrium, affecting approximately 20% of women in the reproductive age group seeking gynecological care. This condition manifests as a range of debilitating symptoms, including dysmenorrhea, menorrhagia, impaired fertility, and heightened susceptibility to miscarriage and obstetric complications. Substantial research has been dedicated to exploring its underlying molecular mechanisms and developing non-invasive precision medical therapies. ADM is primarily characterized by a dysregulation in sex steroid hormone homeostasis, particularly estrogen and progesterone. However, emerging evidence suggests that additional endocrine mediators and disruptors may play contributory roles in the etiology of ADM. Genetic and epigenetic alterations of endocrine signaling pathways have been implicated as prevailing mechanisms underlying the development and progression of the disease. The present review aims to provide an updated and comprehensive overview of the current understanding of the pathophysiology of ADM, with a particular emphasis on the dysregulated hormonal milieu and the potential involvement of endocrine disruptors. By elucidating these intricate molecular mechanisms, this review seeks to pave the way for novel research directions in the development of targeted therapeutic strategies for ADM management.

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Section: Curcuminmentioning

confidence: 99%

Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies

d’Otreppe,

Patino-García,

Piekos

et al. 2024

Endocrines

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“…Studies suggest a potential role of curcumin as an anti-inflammatory, anti-tumor, or anti-aging agent [ 55 ]. A growing body of literature additionally points to a possible pharmacological effect of this compound in treating endometriosis, including a study by Singh et al [ 56 ], which showed that curcumin could restore hemostasis in endometrial dysfunction. Vallée and Lecarpentier [ 57 ] have summarized the mechanisms of action of curcumin related to its effects on endometriosis: (i) anti-inflammatory activity—decreasing the activity of the NF-κB pathway at different stages of the disease, resulting in a decrease in the expression of inflammatory factors such as COX-2, TNFα, IL-1/6/8; (ii) decreasing the activity of VEGF, resulting in a decrease in PI3K/AKT pathway signaling associated with angiogenesis, proliferation, as well as apoptosis; (iii) antioxidant activity by decreasing MAPK/ERK pathway signaling related to oxidative stress; (iv) induction of programmed cell death by decreasing the activity of anti-apoptotic Bcl-2 proteins; and (v) reduction of MMPs expression, mainly MMP-9, leading to reduced development of endometriosis implants.…”

Section: Polyphenolsmentioning

confidence: 99%

The Role of Selected Dietary Factors in the Development and Course of Endometriosis

et al. 2023

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Endometriosis is a chronic disease with a complex, heterogeneous pathogenesis that affects about 10% of women of reproductive age, causing pain and leading to infertility. Treatment consists of administering pharmacological agents (resulting in a reduction of estrogen levels and inflammation), as well as the surgical removal of endometriotic lesions. Unfortunately, despite a wide range of available therapies, there is still a high recurrence rate after surgery. Consequently, it is necessary to improve the outcome of patients with endometriosis. In this context, there is growing interest in possible dietary modification to support or complement classic treatment options and even serve as a potential alternative to hormone therapy. In addition, a growing number of studies indicate positive effects of selected dietary factors on the development and course of endometriosis. This review article focuses on the potentially beneficial effects of compounds from the polyphenol group (curcumin, epigallocatechin gallate, quercetin, resveratrol), vitamins, and selected micronutrients on endometriosis. The results indicate the potential of the selected ingredients in fighting the disease. However, most of the studies have been performed on experimental animal models, with a smaller proportion looking at the actual effects of use among women. Therefore, well-designed studies are needed to assess the importance of a well-chosen diet and the effects of specific dietary factors on the health of women suffering from endometriosis.

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“…Without effective control, it may cause uterine myositis. 2 If treatment is incomplete, repeated flare-ups of inflammation will occur. Clinically, antibiotics and artificial estrogen and progesterone cycles are often used as treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Irregular menstruation, increased leukorrhea, pelvic pain, and dysmenorrhea are common symptoms. Without effective control, it may cause uterine myositis 2 . If treatment is incomplete, repeated flare‐ups of inflammation will occur.…”

Section: Introductionmentioning

confidence: 99%

TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)‐induced inflammatory injury in endometritis by inhibiting NF‐kappaB activation

Qian,

Wang,

et al. 2023

Immunity Inflam & Disease

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BackgroundEndometritis seriously affects the health of women, and it is important to identify new targets for its treatment.ObjectiveThis study aimed to explore the role of TNFAIP3 interacting protein 2 (TNIP2) in endometritis through human endometrial epithelial cells (hEECs) stimulated by lipopolysaccharide (LPS).MethodshEECs were induced with LPS to build a cellular model of endometritis. Cell growth and apoptosis were detected by cell counting kit‐8 and flow cytometry. The TNIP2 mRNA and protein levels were measured using reverse transcription quantitative polymerase chain reaction (RT‐qPCR) and western blot analysis, respectively. The caspase3 activity was calculated using a Caspase3 activity kit. Interleukin (IL)−1β, IL‐6, and tumor necrosis factor‐alpha (TNF‐α) levels were determined by enzyme‐linked‐immunosorbent‐assay. The reactive oxygen species (ROS), lactate dehydrogenase (LDH), catalase (CAT), and superoxide dismutase (SOD) levels were determined using the corresponding kits. Nuclear factor‐kappaB (NF‐κB) pathway was determined by western blot assay.ResultsTNIP2 was downregulated in the LPS‐induced endometritis cell model. Cell viability was reduced, apoptosis was enhanced, and IL‐6, IL‐1β, and TNF‐α levels increased in LPS‐induced hEECs. Additionally, LDH activity and ROS concentration were upregulated, whereas CAT and SOD activities were downregulated in LPS‐induced hEECs. These results were reversed by TNIP2 overexpression. Moreover, the results hinted that NF‐κB was involved in the effects of TNIP2 on the LPS‐induced endometritis cell model.ConclusionTNIP2 alleviated endometritis by inhibiting the NF‐κB pathway, suggesting a potential therapeutic target for endometritis.

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Therapeutic potential of curcumin in endometrial disorders: Current status and future perspectives

Cited by 5 publications

References 83 publications

Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies

Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies

The Role of Selected Dietary Factors in the Development and Course of Endometriosis

TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)‐induced inflammatory injury in endometritis by inhibiting NF‐kappaB activation

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