Therapeutic Potential of Cannabinoids—Retrospective and Historical Developments

Makowiecka, Joanna; Wielgus, Karolina

doi:10.1080/15440478.2013.861782

Cited by 5 publications

(4 citation statements)

References 54 publications

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“…Cannabinoids are emerging as a new line of natural therapy for various debilitating diseases, such as cancers, after historically being utilized primarily for palliative applications such as pain modulation (Bell & Kalso, 2021; Mosley et al, 2021). They are chemical derivatives of the C. sativa plant, renowned for its recreational and medicinal benefits for thousands of years (Andre et al, 2016; Makowiecka & Wielgus, 2014). Nowadays, cannabinoids are well‐known pharmacological effectors that can be utilized as analgesics, hypnotics, and appetite inducers (Mahmoudinoodezh et al, 2022; Malhotra et al, 2021; Peyton et al, 2021).…”

Section: Cannabinoids and Their Potential Therapeutic Effects In Mela...mentioning

confidence: 99%

Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment

Bachari,

Nassar,

Schanknecht

et al. 2023

WIREs Mechanisms of Disease

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Melanoma is one of the leading fatal forms of cancer, yet from a treatment perspective, we have minimal control over its reoccurrence and resistance to current pharmacotherapies. The endocannabinoid system (ECS) has recently been accepted as a multifaceted homeostatic regulator, influencing various physiological processes across different biological compartments, including the skin. This review presents an overview of the pathophysiology of melanoma, current pharmacotherapy used for treatment, and the challenges associated with the different pharmacological approaches. Furthermore, it highlights the utility of cannabinoids as an additive remedy for melanoma by restoring the balance between downregulated immunomodulatory pathways and elevated inflammatory cytokines during chronic skin conditions as one of the suggested critical approaches in treating this immunogenic tumor.This article is categorized under: Cancer > Molecular and Cellular Physiology

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Section: Cannabinoids and Their Potential Therapeutic Effects In Mela...mentioning

confidence: 99%

Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment

Bachari,

Nassar,

Schanknecht

et al. 2023

WIREs Mechanisms of Disease

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“…Cannabis has been known by numerous names such as hemp, hashish, bhang, and weed. C. sativa is one of the oldest cultivated plants and has been used for thousands of years, not only for its nutritional value but also for medicinal and textile applications [10,11]. It has been used in the treatment of various diseases due to its impacts as an analgesichypnotic, antiepileptic and antispasmodic, appetite stimulant, prophylactic, antidepressant, tranquiliser, antiasthmatic, oxytocic (stimulant of uterine contraction during childbirth), topical anesthetic, and antibiotic [12].…”

Section: Cannabis Sativa and Cannabinoidsmentioning

confidence: 99%

The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

Singh

Nassar

Bachari

et al. 2021

Cancers

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Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of cancers. This analysis may provide pharmacological insights into the selection of specific cannabinoids for the development of antitumor drugs for the treatment of prostate cancer.

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“…It has been long recognized that Cannabis sativa L. has a great potential for medical application for different human diseases [ 1 , 2 ]. Its first medical use was marked in Central Asia, including China and India, where C. sativa was used to treat several conditions nearly five millennia ago [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cannabidiol is one of the major nonpsychotropic constituents of C. sativa and it is considered a promising therapeutic agent due to its already proven effectiveness against neurological diseases [ 1 , 2 , 4 , 5 ]. CBD belongs to the group of terpenophenols.…”

Section: Introductionmentioning

confidence: 99%

Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action

Ożarowski

Karpiński

Zielińska

et al. 2021

IJMS

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As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer’s disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach.

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Therapeutic Potential of Cannabinoids—Retrospective and Historical Developments

Cited by 5 publications

References 54 publications

Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment

Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment

The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action

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