Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair

Hong, Soon Jun; Traktuev, Dmitry O.; March, Keith L.

doi:10.1097/mot.0b013e328334f074

Cited by 141 publications

(116 citation statements)

References 81 publications

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“…Human ASCs were transplanted into damaged disc segments in rats, and were found to restore the degenerated intervertebral disc [75]. Based on the promising results of animal model studies, certain clinical trials have also been initiated [78]. There is a growing number of preclinical studies examining the potential of ASCs.…”

Section: Neuronal Differentiationmentioning

confidence: 99%

Stem cells from adipose tissue

Witkowska-Zimny

Walenko

2011

Cellular and Molecular Biology Letters

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This is a review of the growing scientific interest in the developmental plasticity and therapeutic potential of stromal cells isolated from adipose tissue. Adipose-derived stem/stromal cells (ASCs) are multipotent somatic stem cells that are abundant in fat tissue. It has been shown that ASCs can differentiate into several lineages, including adipose cells, chondrocytes, osteoblasts, neuronal cells, endothelial cells, and cardiomyocytes. At the same time, adipose tissue can be harvested by a minimally invasive procedure, which makes it a promising source of adult stem cells. Therefore, it is believed that ASCs may become an alternative to the currently available adult stem cells (e.g. bone marrow stromal cells) for potential use in regenerative medicine. In this review, we present the basic information about the field of adipose-derived stem cells and their potential use in various applications.

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Section: Neuronal Differentiationmentioning

confidence: 99%

Stem cells from adipose tissue

Witkowska-Zimny

Walenko

2011

Cellular and Molecular Biology Letters

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“…Such cells have already been used to correct cranial defects in humans, 119 and preliminary studies in man to rectify cardiovascular 134,135 and soft tissue [136][137][138] defects hold hope for the future use of ADSCs in the treatment of muscle and cartilage defects and heart infarcts. However, before this becomes a reality, there are a number of technical problems that need to be overcome.…”

Section: Fat and The Futurementioning

confidence: 99%

Once fat was fat and that was that : our changing perspectives on adipose tissue

Ferris

Crowther

2011

CardioVascular Journal of Africa

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Past civilisations saw excess body fat as a symbol of wealth and prosperity as the general population struggled with food shortages and famine. Nowadays it is recognised that obesity is associated with co-morbidities such as cardiovascular disease and diabetes. Our views on the roll of adipose tissue have also changed, from being solely a passive energy store, to an important endocrine organ that modulates metabolism, immunity and satiety. The relationship between increased visceral adiposity and obesity-related co-morbidities has lead to the recognition that variation in fat distribution contributes to ethnic differences in the prevalence of obesity-related diseases. Our current negative view of adipose tissue may change with the use of pluripotent adipose-derived stromal cells, which may lead to future autologous stem cell therapies for bone, muscle, cardiac and cartilage disorders. Here, we briefly review the concepts that adipose tissue is an endocrine organ, that differences in body fat distribution underline the aetiology of obesity-related co-morbidities, and the use of adipose-derived stem cells for future therapies.

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“…Briefly, lipoaspirate (300-600 ml) was been isolated and characterized (4,49), and are currently being tested in clinical trials (12). MSCs are frequently washed repeatedly to remove erythrocytes and leukocytes with Hanks' balanced salt solution (HBSS; Gibco, obtained from the stromal-vascular fraction (SVF) of AT cells.…”

Section: Introductionmentioning

confidence: 99%

Human Adipose Tissue as a Source of Cells with Angiogenic Potential

2012

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Endothelial cells (ECs) are involved in the process of angiogenesis, the outgrowth of new vessels from preexisting blood vessels. If available in sufficiently large numbers, ECs could be used therapeutically to establish blood flow through in vitro engineered tissues and tissues suffering from severe ischemia. Adipose tissue (AT) is an easily available source of large number of autologous ECs. Here we describe the isolation, in vitro expansion, and characterization of human AT derived ECs (AT-ECs). AT-ECs proliferated rapidly through 15-20 population doublings. The cultured cells showed cobblestone morphology and expressed EC markers including CD31, CD144, eNOS, CD309, CD105, von Willebrand factor, CD146, CD54, and CD102. They bound Ulex europaeus agglutinin I lectin and took up DiI-Ac-LDL. The AT-ECs formed capillary-like tubes in Matrigel in vitro and formed functional blood vessels in Matrigel following subcutaneous injection into immunodeficient mice. In conclusion, AT-ECs reach clinically significant cell numbers after few population doublings and are easily accessible from autologous AT, which also contains mesenchymal stem cells/ pericytes. Thus, AT yields two cell populations that may be used together in the treatment of tissue ischemia and in clinical applications of tissue engineering.

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Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair

Abstract: ASCs may ultimately represent a valuable therapeutic option in tissue rescue and repair based on their ready availability, proangiogenesis and antiapoptotic factor secretion, immunomodulatory effects, and capacity for multilineage differentiation and ready expansion.

Cited by 141 publications

References 81 publications

Stem cells from adipose tissue

Stem cells from adipose tissue

Once fat was fat and that was that : our changing perspectives on adipose tissue

Human Adipose Tissue as a Source of Cells with Angiogenic Potential

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