Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules

Vigderman, Leonid; Zubarev, Eugene R.

doi:10.1016/j.addr.2012.05.004

Cited by 278 publications

(210 citation statements)

References 143 publications

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“…AuNPs also possess strong binding affinity towards organic molecules containing thiol and amine groups [8][9][10] . Drug conjugation with AuNPs can be achieved either by direct conjugation of drug with AuNPs or by drug conjugation with surface modified gold nanoparticles [11][12][13][14] . Also electrostatic or hydrogen bond attachment of drug with AuNPs may be a better strategy than covalent linkage [15] .…”

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confidence: 99%

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

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Kiroula, et al.: Glutathione-modified Gold Nanoparticles of GanciclovirThis article reports that ganciclovir-loaded gold nanoparticles were developed via glutathione surface modification. Citrate-reduced gold nanoparticles were prepared first from chloroauric acid. Further the surface of gold nanoparticles was modified with glutathione. Then ganciclovir was loaded onto the glutathione-modified gold nanoparticles through the reaction between carboxyl group of glutathione and amino group of ganciclovir. Gold nanoparticles were characterized by photon correlation spectroscopy, transmission electron microscopy and infrared spectroscopy. Drug loading of 87.27±2.52% was observed for ganciclovir-loaded gold nanoparticles. The particle size distribution of gold nanoparticles ranged from 26.3 to 31 nm. Thus ganciclovir-loaded gold nanoparticles were successfully prepared, which might further improve the oral bioavailability of ganciclovir.

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confidence: 99%

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

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“…AuNPs are used for many biomedical applications including drug delivery vectors based on covalent reaction, drug encapsulation, electrostatic adsorption and non-covalent conjugation [11,105,[179][180][181][182]. AuNPs can improve anticancer effects of many drugs by increasing drug delivery to cancer cells [183], which can be facilitated by passive or active targeting mechanisms [184]. Several studies showed that AuNPs interact with serum proteins.…”

Section: Metal-based Nanoparticlesmentioning

confidence: 99%

“…Since AuNPs are good absorbers of ionizing radiation they can also be used for enhancement of radiotherapy (RT). Provided targeting AuNPs are employed the above mentioned combination therapies will selectivity damage specific cells [57,160,183,[203][204][205]. Application of NPs with radiotherapy is an emerging field to explore the combination of drug targeting and radiation dose enhancement.…”

Section: B) A)mentioning

confidence: 99%

Supramolecular nanoscale assemblies for cancer diagnosis and therapy

Coelho

Pereira

Juzeniene

et al. 2015

Journal of Controlled Release

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Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic treatments such as chemotherapy or radiotherapy. In this article the relation between physicochemical properties and capacity of a nanosystem to deliver therapeutic agents into pathological sites is discussed. Most promising examples of drug delivery systems are reviewed, and, in particular, the design of a carbohydrate based matrix with entrapped gold nanoparticles is highlighted.

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“…Nevertheless, imaginative variations have been found, such as the photothermal release of DNA cargos upon laser irradiation. 10 QDs are yet another class of which we hear more and more in nanomedicine, especially in applications of multimodal imaging. The battle against cancer needs weapons of increasing sophistication, including tools to locate micrometastasis with exquisite spatiotemporal resolution.…”

mentioning

confidence: 99%