Nanomaterials for (Nano)medicine

Marchesan, Silvia; Prato, Maurizio

doi:10.1021/ml3003742

Cited by 109 publications

(78 citation statements)

References 20 publications

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“…The simplest explanation of this new term is an identification of diseased tissues or cells and delivery of a medicine or a therapy (e.g., heating) to this very site of pathology. A gold-silica nanoparticle system for optical imaging and photothermal ablation has been developed [4][5][6].…”

Section: Nanomaterials Used In Medicinementioning

confidence: 99%

Medical Aspects of Nanomaterial Toxicity

Siemianowicz¹,

Likus²,

Markowski³

2015

Nanomaterials - Toxicity and Risk Assessment

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Nanosilver is the most popular and most studied nanomaterial, however, a family of nanomaterials is rapidly enlarging. They are used in various branches of industry and everyday life. In medicine new nanomaterials can be used either alone or in combination with other "classical" drugs, e.g. cytostatic drugs or antibiotics. They can be also used as diagnostic agents. A development of nanoparticles has led to a new combination of diagnostic and therapy -theranostic. Size of a particle makes a difference not only between bulk material and nanomaterial, but also in their properties and toxicity. Nanomaterials can have beneficial properties, but can also be toxic. New issues concerning nanomaterials arise -an industrial exposure and environmental pollution. They can enter human body in various ways. Cellular mechanisms of nanomaterial toxicity comprise mainly a generation of reactive oxygen species and genotoxicity. The differences between toxicity of fine particles and nanoparticles have led to an origin of a new branch of science, nanotoxicology.

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Section: Nanomaterials Used In Medicinementioning

confidence: 99%

Medical Aspects of Nanomaterial Toxicity

Siemianowicz¹,

Likus²,

Markowski³

2015

Nanomaterials - Toxicity and Risk Assessment

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“…On the other hand, although CNTs represent an important niche in the field of innovative nanomaterials for next-generation theranostic nanomedicines (i.e. having therapeutic and diagnostic functions combined) [3], no CNT pharmaceutical product for internal use is anywhere near the market. The only two clinical trials on CNTs started in 2011 and feature them solely as components of external medical devices for cancer diagnostics (i.e.…”

Section: Introductionmentioning

confidence: 99%

The winding road for carbon nanotubes in nanomedicine

et al. 2015

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Carbon nanotubes (CNTs) are recognized as promising nanomaterials for technological advancement. However, the stigma of structural similarity with asbestos fibers has slowed down progress of CNTs in nanomedicine. Nevertheless, it also prompted thorough studies that have revealed that functionalized CNTs (fCNTs) can biologically behave in a very different and safer manner. Here we review pristine and fCNT fate in biological settings, focusing on the importance of protein interaction, formation of the protein corona, and modulation of immune response. The emerging consensus on the desirable fCNT properties to achieve immunological neutrality, and even biodegradation, shows great promise for CNT adoption in medicine

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“…The improvement of existing therapeutics has the potential to give promising solutions to many illnesses, aiming for a better, more efficient and affordable healthcare [3,4]. Mankind is still fighting against a high number of serious and complex illnesses like cancer, cardiovascular diseases, multiple sclerosis, Alzheimer's and Parkinson's disease, diabetes as well as different kinds of serious inflammatory or infectious diseases such as Acquired Immune Deficiency Syndrome (AIDS).…”

Section: Introductionmentioning

confidence: 99%