Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

Iannazzo, Daniela; Pistone, Alessandro; Galvagno, S.; Ferro, Stefania; Luca, Laura De; Monforte, Anna Maria; Ros, Tatiana Da; Hadad, Caroline; Prato, Maurizio; Pannecouque, Christophe

doi:10.1016/j.carbon.2014.11.007

Cited by 57 publications

(68 citation statements)

References 42 publications

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“…Iannazzo et al showed that surface functionalization led to critical changes of physical, chemical, and biological properties of CNTs, particularly modifications of their antiviral activity [35]. The results of the study indicated the important role of the free carboxylic groups as hydrophilic functionality affecting dispersibility of the CNTs, and their interaction with biological molecular complexes by means of electrostatic or hydrogen bonds.…”

Section: Carbon Arc-discharge Methodsmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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Unique chemical, physical, and biological features of carbon nanotubes make them an ideal candidate for myriad applications in industry and biomedicine. Carbon nanotubes have excellent electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion, nano-size, and a high surface area, which can be tailored and functionalized on demand. This review discusses the progress and main fields of bio-medical applications of carbon nanotubes based on recently-published reports. It encompasses the synthesis of carbon nanotubes and their application for bio-sensing, cancer treatment, hyperthermia induction, antibacterial therapy, and tissue engineering. Other areas of carbon nanotube applications were out of the scope of this review. Special attention has been paid to the problem of the toxicity of carbon nanotubes.

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Section: Carbon Arc-discharge Methodsmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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“…For instance, Iannazzo et al reported that MWCNTs modified by hydrophilic moieties at free carboxylic groups induce a better water dispersibility, which is relevant for the interaction between biological tissue and nanomaterials. 105 Both Bianco et al and Pistone et al highlighted that the biocompatibility, biodegradability, and release ability of CNTs can be modified by the surface functionalization (eg, hydrophilic PEG chain) and the introduction of structural defects.…”

mentioning

confidence: 99%

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Zhang¹,

Tang²,

Liu³

et al. 2017

IJN

120

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Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity. Using nanoparticles as the carriers to realize passive targeting and active targeting can improve the efficacy of chemotherapy drugs significantly, reduce the mortality rate of cancer patients, and improve the quality of life of patients. In recent years, there has been extensive research on nanocarriers. In this review, the effects of several major parameters of nanoparticles on their physical and chemical properties are reviewed, and then the recent progress in the application of several commonly used nanoparticles is presented.

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“…SEM analysis was performed at 1 kV with magnifications ranging from 4000× to 12000×. SEM images were used to analyze the interface between the drug and the polymer [20,21].…”

Section: Surface Morphologymentioning

confidence: 99%

Design and Development of Rilpivirine Nanoparticle Containing Chitosan Using Ionic Gelation Method for Hiv Infections

Patel

2020

Int J Pharm Pharm Sci

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Objective: The primary objective of the current research was to prepare rilpivirine loaded Nanoparticles containing Chitosan using the ionic gelation method for HIV infections. Methods: The nanoparticles of rilpivirine were prepared using the ionic gelation technique. Further, nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and in vitro drug release. Results: The optimized nanoparticles were found with a particle size of 130.30±5.29 nm (mean±SD) and entrapment efficiency (% EE) of 77.10±0.50%. Scanning electron microscopy technique exposed spherical particles with uniform size. It was observed that the nanoparticles created showed the absence of the crystalline nature of the drug and its switch to the amorphous state. Results showed that more than 45% of the pure drug is released in 50 min and after 90 min almost about 95% of the drug is released. Conclusion: The research study concluded that the in vitro release profile of nanoparticles was found to be sustained up to 24 hr. Sustained release of the rilpivirine could improve patient obedience to drug regimens, growing action effectiveness.

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Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

Cited by 57 publications

References 42 publications

The Advances in Biomedical Applications of Carbon Nanotubes

The Advances in Biomedical Applications of Carbon Nanotubes

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Design and Development of Rilpivirine Nanoparticle Containing Chitosan Using Ionic Gelation Method for Hiv Infections

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