2008
DOI: 10.2169/internalmedicine.47.0949
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Therapeutic Outcome of Cyclic VAD (Vincristine, Doxorubicin and Dexamethasone) Therapy in Primary Systemic AL Amyloidosis Patients

Abstract: Objective Intensive chemotherapy targeting plasma cell dyscrasia has been recently employed for the treatment of primary systemic AL amyloidosis. We prospectively studied the clinical usefulness of cyclic VAD (vincristine, doxorubicin and dexamethasone)

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Cited by 7 publications
(3 citation statements)
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References 16 publications
(9 reference statements)
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“…Although the mechanisms by which VAD ameliorate the infiltrative cardiomyopathy are still unclear, a recent report suggests that the reduction of amyloid depositions resulting from decreased precursor protein may be the mechanism by which VAD exert their therapeutic effects [8]. The cardiac function of this patient remained unchanged after administration of VAD chemotherapy; however, a similar pathogenic mechanism may be involved in the development of refractory pleural effusion without cardiac decompensation.…”
Section: Discussionmentioning
confidence: 88%
“…Although the mechanisms by which VAD ameliorate the infiltrative cardiomyopathy are still unclear, a recent report suggests that the reduction of amyloid depositions resulting from decreased precursor protein may be the mechanism by which VAD exert their therapeutic effects [8]. The cardiac function of this patient remained unchanged after administration of VAD chemotherapy; however, a similar pathogenic mechanism may be involved in the development of refractory pleural effusion without cardiac decompensation.…”
Section: Discussionmentioning
confidence: 88%
“…Four fulfi lled criteria for an objective hematologic response [46]. Vincristine use is contraindicated in patients with amyloid peripheral neuropathy, and doxorubicin is a poor choice for those with amyloid cardiomyopathy, which has a high prevalence.…”
Section: Dexamethasone-based Regimensmentioning
confidence: 99%
“…Chronic liver injury due to amyloidosis can be successfully treated with cytotoxic substances [11,12]. A chemotherapy regimen similar to the treatment given in multiple myeloma might be promising [13,14]. Moreover, a specific therapy dissolving the amyloid deposits already incorporated into the tissue does not exist.…”
mentioning
confidence: 99%